{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T08:29:23Z","timestamp":1746088163087},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Leishmaniasis is endemic in the Indian subcontinent with predominance of visceral leishmaniasis (VL) due to <jats:italic>Leishmania donovani<\/jats:italic>. Cutaneous leishmaniasis (CL) is uncommon, and mucocutaneous leishmaniasis (MCL) is rarely reported in this region. Recent reports reveal a changing epidemiology and atypical manifestations. A retrospective study of 52 suspected cases with cutaneous and mucosal involvement seen from January 2008 to December 2018 in a tertiary care setting in a non-endemic state in southern India is reported. Twelve patients were confirmed to have leishmaniasis; seven had MCL, two had CL, and three had post-kala-azar dermal leishmaniasis (PKDL). All cases were male, with a median age of 41.5 years (interquartile range, 30\u201355.5 years), and the median duration of the disease was 6 years (interquartile range, 1\u20139.5 years). Patients with MCL had mucosal involvement including destructive ulcero-proliferative lesions due to delayed diagnosis; none had a history of travel to countries endemic for MCL and all were attributable to <jats:italic>L. donovani<\/jats:italic> species. On the other hand, <jats:italic>Leishmania major<\/jats:italic> which was the causative species in both CL patients was associated with travel to the Middle East. Patients with PKDL presented with multiple plaques and hypopigmented patches; one had concomitant VL and all were from endemic areas. Hitherto uncommon MCL, caused by potentially atypical variants of <jats:italic>L. donovani<\/jats:italic>, has emerged as a new manifestation of leishmaniasis in this region. A high index of suspicion based on lesions seen and history of travel combined with PCR-based diagnostics are required to confirm diagnosis for the various skin manifestations of leishmaniasis.<\/jats:p>","DOI":"10.4269\/ajtmh.20-0938","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T07:00:50Z","timestamp":1609311650000},"page":"928-933","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: A Single-Center Case Series on Skin Manifestations of Leishmaniasis from a Non-Endemic State in Southern India"],"prefix":"10.4269","volume":"104","author":[{"given":"Santhi John","family":"Tharakan","sequence":"first","affiliation":[{"name":"1Departments of Dermatology Unit-II, Christian Medical College, Vellore, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dincy","family":"Peter CV","sequence":"additional","affiliation":[{"name":"1Departments of Dermatology Unit-II, Christian Medical College, Vellore, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajiv","family":"Karthik","sequence":"additional","affiliation":[{"name":"2Infectious Diseases, Christian Medical College, Vellore, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vedantam","family":"Rupa","sequence":"additional","affiliation":[{"name":"3ENT Unit-III, Christian Medical College, Vellore, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winsley","family":"Rose","sequence":"additional","affiliation":[{"name":"4Child Health Unit-III, Christian Medical College, Vellore, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meera","family":"Thomas","sequence":"additional","affiliation":[{"name":"5Pathology, Christian Medical College, Vellore, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malathi","family":"Manuel","sequence":"additional","affiliation":[{"name":"6The Wellcome Trust Research Laboratory, Christian Medical College, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"Rupali","sequence":"additional","affiliation":[{"name":"2Infectious Diseases, Christian Medical College, Vellore, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Pulimood","sequence":"additional","affiliation":[{"name":"1Departments of Dermatology Unit-II, Christian Medical College, Vellore, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sitara Swarna","family":"Rao Ajjampur","sequence":"additional","affiliation":[{"name":"6The Wellcome Trust Research Laboratory, Christian Medical College, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/3\/article-p928.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/104\/3\/article-p928.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T17:29:11Z","timestamp":1614792551000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/3\/article-p928.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.20-0938","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,3]]}}}