{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:48:21Z","timestamp":1778032101317,"version":"3.51.4"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In November 2018, we diagnosed a cluster of falciparum malaria cases in three Chilean travelers returning from Nigeria. Two patients were treated with sequential intravenous artesunate plus oral atovaquone\/proguanil (AP) and one with oral AP. The third patient, a 23-year-old man, presented with fever on day 29 after oral AP treatment and was diagnosed with recrudescent falciparum malaria. The patient was then treated with oral mefloquine, followed by clinical recovery and resolution of parasitemia. Analysis of day 0 and follow-up blood samples, collected on days 9, 29, 34, 64, and 83, revealed that parasitemia had initially decreased but then increased on day 29. Sequencing confirmed Tyr268Cys mutation in the <jats:italic>cytochrome b<\/jats:italic> gene, associated with atovaquone resistance, in isolates collected on days 29 and 34 and <jats:italic>P. falciparum dihydrofolate reductase<\/jats:italic> mutation Asn51Ile, associated with proguanil resistance in all successfully sequenced samples. Molecular characterization of imported malaria contributes to clinical management in non-endemic countries, helps ascertain the appropriateness of antimalarial treatment policies, and contributes to the reporting of drug resistance patterns from endemic regions.<\/jats:p>","DOI":"10.4269\/ajtmh.20-1095","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T15:32:43Z","timestamp":1617031963000},"page":"1811-1813","source":"Crossref","is-referenced-by-count":10,"title":["Atovaquone\/Proguanil Resistance in an Imported Malaria Case in Chile"],"prefix":"10.4269","volume":"104","author":[{"given":"Stella M.","family":"Chenet","sequence":"first","affiliation":[{"name":"1Instituto de Enfermedades Tropicales, Universidad Nacional Toribio Rodr\u00edguez de Mendoza (UNTRM), Chachapoyas, Per\u00fa;"},{"name":"2Instituto de Salud P\u00fablica de Chile (ISP), Santiago, Chile;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Oyarce","sequence":"additional","affiliation":[{"name":"2Instituto de Salud P\u00fablica de Chile (ISP), Santiago, Chile;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Fernandez","sequence":"additional","affiliation":[{"name":"2Instituto de Salud P\u00fablica de Chile (ISP), Santiago, Chile;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Tapia-Limonchi","sequence":"additional","affiliation":[{"name":"1Instituto de Enfermedades Tropicales, Universidad Nacional Toribio Rodr\u00edguez de Mendoza (UNTRM), Chachapoyas, Per\u00fa;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Weitzel","sequence":"additional","affiliation":[{"name":"3Facultad de Medicina Cl\u00ednica Alemana, Universidad del Desarrollo, Santiago, Chile;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan R.","family":"Tejedo","sequence":"additional","affiliation":[{"name":"1Instituto de Enfermedades Tropicales, Universidad Nacional Toribio Rodr\u00edguez de Mendoza (UNTRM), Chachapoyas, Per\u00fa;"},{"name":"4Departamento de Biolog\u00eda Molecular e Ingenier\u00eda Bioqu\u00edmica, Universidad Pablo de Olavide (UPO), Seville, Spain;"},{"name":"5Diabetes and Associated Metabolic Diseases Networking Biomedical Research Centre (CIBERDEM), Madrid, Spain;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkatachalam","family":"Udhayakumar","sequence":"additional","affiliation":[{"name":"6Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Isabel","family":"Jercic","sequence":"additional","affiliation":[{"name":"2Instituto de Salud P\u00fablica de Chile (ISP), Santiago, Chile;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi W.","family":"Lucchi","sequence":"additional","affiliation":[{"name":"6Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/5\/article-p1811.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/104\/5\/article-p1811.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T20:41:32Z","timestamp":1629924092000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/5\/article-p1811.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,5]]},"references-count":0,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.20-1095","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,5]]}}}