{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:32:50Z","timestamp":1787031170485,"version":"build-2736575974"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,10]]},"abstract":"<jats:p>Dengue patients with comorbidities may be at higher risk of death. In this cross-sectional study, healthcare databases from Mexico (2008\u20132014), Brazil (2008\u20132015), and Colombia (2009\u20132017) were used to identify hospitalized dengue cases and their comorbidities. Case fatality rates (CFRs), relative risk, and odds ratios (OR) for in-hospital mortality were determined. Overall, 678,836 hospitalized dengue cases were identified: 68,194 from Mexico, 532,821 from Brazil, and 77,821 from Colombia. Of these, 35%, 5%, and 18% were severe dengue, respectively. Severe dengue and age \u2265 46 years were associated with increased risk of in-hospital mortality. Comorbidities were identified in 8%, 1%, and 4% of cases in Mexico, Brazil, and Colombia, respectively. Comorbidities increased hospitalized dengue CFRs 3- to 17-fold; CFRs were higher with comorbidities regardless of dengue severity or age. The odds of in-hospital mortality were significantly higher in those with pulmonary disorders (11.6 [95% CI 7.4\u201318.2], 12.7 [95% CI 9.3\u201317.5], and 8.0 [95% CI 4.9\u201313.1] in Mexico, Brazil, and Colombia, respectively), ischemic heart disease (23.0 [95% CI 6.6\u201379.6], 5.9 [95% CI 1.4\u201324.6], and 7.0 [95% CI 1.9\u201325.5]), and renal disease\/failure (8.3 [95% CI 4.8\u201314.2], 8.0 [95% CI 4.5\u201314.4], and 9.3 [95% CI 3.1\u201328.0]) across the three countries; the odds of in-hospital mortality from dengue with comorbidities was at least equivalent or higher than severe dengue alone (4.5 [95% CI 3.4\u20136.1], 9.6 [95% CI 8.6\u201310.6], and 9.0 [95% CI 6.8\u201312.0). In conclusion, the risk of death because of dengue increases with comorbidities independently of age and\/or disease severity.<\/jats:p>","DOI":"10.4269\/ajtmh.20-1163","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T11:33:38Z","timestamp":1620646418000},"source":"Crossref","is-referenced-by-count":16,"title":["Mortality among Hospitalized Dengue Patients with Comorbidities in Mexico, Brazil, and Colombia"],"prefix":"10.4269","author":[{"given":"Alejandro E.","family":"Macias","sequence":"first","affiliation":[{"name":"1\u00c1rea De Microbiolog\u00eda, Departamento De Medicina y Nutrici\u00f3n, Universidad de Guanajuato, Guanajuato, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme L.","family":"Werneck","sequence":"additional","affiliation":[{"name":"2Instituto de Estudos em Sa\u00fade Coletiva, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Castro","sequence":"additional","affiliation":[{"name":"3Los Andes University, Bogota, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Mascare\u00f1as","sequence":"additional","affiliation":[{"name":"4Sanofi Pasteur, Lyon, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Coudeville","sequence":"additional","affiliation":[{"name":"4Sanofi Pasteur, Lyon, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Morley","sequence":"additional","affiliation":[{"name":"5Ariana Pharmaceuticals, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Recamier","sequence":"additional","affiliation":[{"name":"5Ariana Pharmaceuticals, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Guergova-Kuras","sequence":"additional","affiliation":[{"name":"5Ariana Pharmaceuticals, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Etcheto","sequence":"additional","affiliation":[{"name":"5Ariana Pharmaceuticals, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Puentes-Rosas","sequence":"additional","affiliation":[{"name":"6Sanofi Pasteur, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Baurin","sequence":"additional","affiliation":[{"name":"4Sanofi Pasteur, Lyon, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myew-Ling","family":"Toh","sequence":"additional","affiliation":[{"name":"4Sanofi Pasteur, Lyon, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/aop\/article-10.4269-ajtmh.20-1163\/article-10.4269-ajtmh.20-1163.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/aop\/article-10.4269-ajtmh.20-1163\/article-10.4269-ajtmh.20-1163.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T11:33:39Z","timestamp":1620646419000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/aop\/article-10.4269-ajtmh.20-1163\/article-10.4269-ajtmh.20-1163.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,10]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4269\/ajtmh.20-1163","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,10]]}}}