{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:39:07Z","timestamp":1784345947705,"version":"3.55.0"},"reference-count":49,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Malaria remains a major global health burden, killing hundreds of thousands annually, especially in sub-Saharan Africa. In December 2019, a novel illness termed COVID-19, caused by SARS-CoV-2, was reported in China. This disease soon spread around the world and was declared a pandemic by the WHO on March 11, 2020. Considering that the malaria burden is high in many low-income tropical countries with little capacity to fund malaria control and eradication programs, the fight against malaria in these regions is likely to be hindered by COVID-19. Indeed, access to health care has generally been limited during the pandemic, whereas malaria interventions, such as seasonal malaria chemoprevention, and distribution of long-lasting insecticide-treated bed nets, have been suspended because of lockdowns. Likewise, the repurposing of antimalarials for the treatment of COVID-19 and a shift in focus from the production of malaria rapid diagnostic tests to COVID-19 rapid diagnostic tests are causes for concern in malaria-endemic regions. COVID-19 has disproportionately affected developed countries, threatening their capacity to aid in malaria control efforts. Here, we address impacts of the COVID-19 pandemic on the management and control of malaria in Africa.<\/jats:p>","DOI":"10.4269\/ajtmh.20-1181","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T07:00:30Z","timestamp":1605164430000},"page":"26-29","source":"Crossref","is-referenced-by-count":61,"title":["Fighting COVID-19 at the Expense of Malaria in Africa: The Consequences and Policy Options"],"prefix":"10.4269","volume":"104","author":[{"given":"Abdullahi Tunde","family":"Aborode","sequence":"first","affiliation":[{"name":"1Healthy Africans Platform, Research and Development Hub, Ibadan, Nigeria;"},{"name":"2Brain Builders Youth Development Initiative, Research Directorate, Ilorin, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth Bitrus","family":"David","sequence":"additional","affiliation":[{"name":"3Hull York Medical School, University of Hull, Hull, United Kingdom;"},{"name":"4Faculty of Pharmaceutical Sciences, Kaduna State University, Kaduna, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Uwishema","sequence":"additional","affiliation":[{"name":"5Department of General Medicine, Karadeniz Technical University, Trabzon, Turkey;"},{"name":"6Oli Health Magazine Organization (OHMO), Kigali, Rwanda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agbendeh Lubem","family":"Nathaniel","sequence":"additional","affiliation":[{"name":"7BRAC James P. Grant School of Public Health, BRAC University, Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jegede Oluwatoyin","family":"Imisioluwa","sequence":"additional","affiliation":[{"name":"8Department of Human Kinetics and Health Education, Adekunle Ajasin University, Akungba Akoko, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherifdeen Bamidele","family":"Onigbinde","sequence":"additional","affiliation":[{"name":"9Department of Biochemistry, Federal University of Agriculture, Abeokuta, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fozia","family":"Farooq","sequence":"additional","affiliation":[{"name":"10Faculty of Pharmaceutical Science, University of Sindh, Jamshoro, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","volume-title":"World Malaria Report 2019","year":"2018"},{"key":"b2","volume-title":"WHO Q&A on the Malaria Vaccine 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shortages","volume":"35","author":"Dada","year":"2020","journal-title":"Pan Afr J"},{"key":"b15","volume-title":"Malaria Epidemics: Detection and Control, Forecasting and Prevention","author":"N\u00e1jera","year":"1998"},{"key":"b16","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1475-2875-11-122","article-title":"Malaria resurgence: a systematic review and assessment of its causes","volume":"11","author":"Cohen","year":"2012","journal-title":"Malar J"},{"key":"b17","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3201\/eid2203.150977","article-title":"Effects of response to 2014\u20132015 Ebola outbreak on deaths from malaria, HIV\/AIDS, and tuberculosis, West Africa","volume":"22","author":"Parpia","year":"2016","journal-title":"Emerg Infect Dis"},{"key":"b18","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S1473-3099(15)70167-2","article-title":"Ebola: the hidden toll","volume":"15","author":"Hamel","year":"2015","journal-title":"Lancet 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