{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:15:53Z","timestamp":1793304953527,"version":"4.5.0"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,5]]},"abstract":"ABSTRACT<\/jats:title>Understanding the movement of antimicrobial resistance genes (ARGs) in the environment is critical to managing their spread. To assess potential ARG transport through the air via urban bioaerosols in cities with poor sanitation, we quantified ARGs and a mobile integron (MI) in ambient air over periods spanning rainy and dry seasons in Kanpur, India (n<\/jats:italic> = 53), where open wastewater canals (OWCs) are prevalent. Gene targets represented major antibiotic groups\u2014tetracyclines (tetA<\/jats:italic>), fluoroquinolines (qnrB<\/jats:italic>), and beta-lactams (bla<\/jats:italic>TEM<\/jats:sub>)\u2014and a class 1 mobile integron (intI1<\/jats:italic>). Over half of air samples located near, and up to 1 km from OWCs with fecal contamination (n<\/jats:italic> = 45) in Kanpur had detectable targets above the experimentally determined limits of detection (LOD): most commonly intI1<\/jats:italic> and tetA<\/jats:italic> (56% and 51% of samples, respectively), followed by bla<\/jats:italic>TEM<\/jats:sub> (8.9%) and qnrB<\/jats:italic> (0%). ARG and MI densities in these positive air samples ranged from 6.9 \u00d7 101<\/jats:sup> to 5.2 \u00d7 103<\/jats:sup> gene copies\/m3<\/jats:sup> air. Most (7\/8) control samples collected 1 km away from OWCs were negative for any targets. In comparing experimental samples with control samples, we found that intI1<\/jats:italic> and tetA<\/jats:italic> densities in air are significantly higher (P<\/jats:italic> = 0.04 and P<\/jats:italic> = 0.01, respectively, alpha = 0.05) near laboratory-confirmed fecal contaminated waters than at the control site. These data suggest increased densities of ARGs and MIs in bioaerosols in urban environments with inadequate sanitation. In such settings, aerosols may play a role in the spread of AR.<\/jats:p>","DOI":"10.4269\/ajtmh.20-1222","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T13:48:17Z","timestamp":1615211297000},"page":"1761-1767","source":"Crossref","is-referenced-by-count":8,"title":["Open Waste Canals as Potential Sources of Antimicrobial Resistance Genes in Aerosols in Urban Kanpur, India"],"prefix":"10.4269","volume":"104","author":[{"given":"Olivia","family":"Ginn","sequence":"first","affiliation":[{"name":"1School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Berendes","sequence":"additional","affiliation":[{"name":"3Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wood","sequence":"additional","affiliation":[{"name":"4Department of Civil and Environmental Engineering and Earth Science, University of Notre Dame, Notre Dame, Indiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Bivins","sequence":"additional","affiliation":[{"name":"5Department of Civil and Environmental Engineering, Duke Global Health Institute, Duke University, Durham, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Rocha-Melogno","sequence":"additional","affiliation":[{"name":"5Department of Civil and Environmental Engineering, Duke Global Health Institute, Duke University, Durham, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Deshusses","sequence":"additional","affiliation":[{"name":"5Department of Civil and Environmental Engineering, Duke Global Health Institute, Duke University, Durham, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachchida N.","family":"Tripathi","sequence":"additional","affiliation":[{"name":"6Department of Civil Engineering, Centre for Environmental Science and Engineering, Indian Institute of Technology, Kanpur, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Bergin","sequence":"additional","affiliation":[{"name":"5Department of Civil and Environmental Engineering, Duke Global Health Institute, Duke University, Durham, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Brown","sequence":"additional","affiliation":[{"name":"7Deparment of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/5\/article-p1761.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/104\/5\/article-p1761.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T20:41:37Z","timestamp":1629924097000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/5\/article-p1761.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,5]]},"references-count":0,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.20-1222","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,5]]}}}