{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:08:16Z","timestamp":1785229696474,"version":"3.55.0"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,7]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p>Rickets is an often-neglected, painful, and disabling childhood condition of impaired bone mineralization. In this case series we describe a cluster of 29 children with severe, painful bone deformities who live in the very remote region of Nagaland in northwest Myanmar. Children were found to have low 25-hydroxyvitamin D, elevated parathyroid hormone, and elevated alkaline phosphatase levels, consistent with nutritional rickets secondary to vitamin D deficiency, calcium deficiency, or a combination of the two. After treatment with vitamin D<jats:sub>3<\/jats:sub> and calcium carbonate, significant improvement was seen in symptoms, biochemistry, and radiography. This is the first report of nutritional rickets in Myanmar in more than 120 years. Vitamin D and calcium supplementation, and food fortification for pregnant women and young children may be required to prevent this potentially devastating disease.<\/jats:p>","DOI":"10.4269\/ajtmh.20-1431","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T16:03:45Z","timestamp":1623081825000},"page":"217-221","source":"Crossref","is-referenced-by-count":5,"title":["Case Report: Children with Severe Nutritional Rickets in the Naga Region in Northwest Myanmar, on the border with India"],"prefix":"10.4269","volume":"105","author":[{"given":"Hein","family":"Aung","sequence":"first","affiliation":[{"name":"1Medical Action Myanmar, Yangon, Myanmar;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyaw","family":"Soe","sequence":"additional","affiliation":[{"name":"2Myanmar Oxford Clinical Research Unit, Yangon, Myanmar;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank F.","family":"Smithuis","sequence":"additional","affiliation":[{"name":"3Department of Radiology, Amsterdam UMC Imaging Center, Amsterdam, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lamb","sequence":"additional","affiliation":[{"name":"2Myanmar Oxford Clinical Research Unit, Yangon, Myanmar;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moe Wint","family":"Aung","sequence":"additional","affiliation":[{"name":"4Department of Endocrinology, Yangon General Hospital, Yangon, Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M.","family":"Smithuis","sequence":"additional","affiliation":[{"name":"1Medical Action Myanmar, Yangon, Myanmar;"},{"name":"2Myanmar Oxford Clinical Research Unit, Yangon, Myanmar;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/1\/article-p217.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/105\/1\/article-p217.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T15:39:10Z","timestamp":1625758750000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/1\/article-p217.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,7]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.20-1431","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,7]]}}}