{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:01:16Z","timestamp":1790190076614,"version":"4.1.0"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Tuberculosis (TB) remains a global problem and a diagnostic challenge, especially in pediatrics. The aim of this study was to describe the clinical, microbiological, radiological, and histopathological data of TB in children. A 7-year retrospective and descriptive cohort study that included 127 patients under 18 years of age with diagnosis of active TB was conducted from 2011 to 2018 in a pediatric hospital. Tuberculosis was microbiologically confirmed using Ziehl\u2013Neelsen (ZN) staining, culture or polymerase chain reaction (PCR) in a total of 94 (74%) cases. Thirty-three cases were defined as probable TB based on tuberculin skin test result and epidemiological evaluation. The TB forms found were lymph node (39.3%), bone (15.7%), lung (13.6%), and meningeal TB (8.6%). The most common symptoms were fever (48.8%) and adenopathy (45.6%). History of contact was established in 34.6%. Positive ZN staining (sensitivity 30%) and culture (sensitivity 37%) were found in 29% and 37.7% of subjects, respectively. About 64.5% depicted abnormal chest X-ray. Xpert MTB\/RIF<jats:sup>\u00ae<\/jats:sup> (PCR) was positive in 9.4% and biopsy was compatible in 52.7% of these samples. It is fundamental to have laboratory and epidemiological evaluation that support the diagnosis of the disease in children and thus, define its management; since, in most cases, early microbiologic confirmation is lacking.<\/jats:p>","DOI":"10.4269\/ajtmh.20-1482","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T23:11:49Z","timestamp":1637622709000},"page":"75-79","source":"Crossref","is-referenced-by-count":3,"title":["Tuberculosis in Children in a Pediatric Hospital in Mexico"],"prefix":"10.4269","volume":"106","author":[{"given":"Napole\u00f3n Gonz\u00e1lez","family":"Salda\u00f1a","sequence":"first","affiliation":[{"name":"1Department of Infectology, Instituto Nacional de Pediatria (INP), Mexico City, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes Mac\u00edas","family":"Parra","sequence":"additional","affiliation":[{"name":"1Department of Infectology, Instituto Nacional de Pediatria (INP), Mexico City, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo Ju\u00e1rez","family":"Olgu\u00edn","sequence":"additional","affiliation":[{"name":"2Department of Pharmacology, Instituto Nacional de Pediatria (INP), Mexico City, Mexico;"},{"name":"3Department of Pharmacology, Faculty of Medicine, Universidad Nacional Aut\u00f3noma de Mexico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Iv\u00e1n Castillo","family":"Bejarano","sequence":"additional","affiliation":[{"name":"1Department of Infectology, Instituto Nacional de Pediatria (INP), Mexico City, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica Punzo","family":"Soto","sequence":"additional","affiliation":[{"name":"2Department of Pharmacology, Instituto Nacional de Pediatria (INP), Mexico City, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca Trujillo","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"2Department of Pharmacology, Instituto Nacional de Pediatria (INP), Mexico City, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/1\/article-p75.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/106\/1\/article-p75.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T12:08:26Z","timestamp":1641384506000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/1\/article-p75.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,5]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.20-1482","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,5]]}}}