{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:31:23Z","timestamp":1771036283126,"version":"3.50.1"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The impact of Zika virus (ZIKV) infection on pregnancies shows regional variation emphasizing the importance of studies in different geographical areas. We conducted a prospective study in Tegucigalpa, Honduras, recruiting 668 pregnant women between July 20, 2016, and December 31, 2016. We performed Trioplex real-time reverse transcriptase\u2013PCR (rRT-PCR) in 357 serum samples taken at the first prenatal visit. The presence of ZIKV was confirmed in seven pregnancies (7\/357, 2.0%). Nine babies (1.6%) had microcephaly (head circumference more than two SDs below the mean), including two (0.3%) with severe microcephaly (head circumference [HC] more than three SDs below the mean). The mothers of both babies with severe microcephaly had evidence of ZIKV infection. A positive ZIKV Trioplex rRT-PCR was associated with a 33.3% (95% CI: 4.3\u201377.7%) risk of HC more than three SDs below the mean.<\/jats:p>","DOI":"10.4269\/ajtmh.20-1483","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T20:29:13Z","timestamp":1615840153000},"page":"1737-1740","source":"Crossref","is-referenced-by-count":7,"title":["Microcephaly Outcomes among Zika Virus\u2013Infected Pregnant Women in Honduras"],"prefix":"10.4269","volume":"104","author":[{"given":"Jackeline","family":"Alger","sequence":"first","affiliation":[{"name":"1Departamento de Laboratorio Cl\u00ednico, Hospital Escuela, Tegucigalpa, Honduras;"},{"name":"2Instituto de Enfermedades Infecciosas y Parasitolog\u00eda Antonio Vidal, Tegucigalpa, Honduras;"},{"name":"3Unidad de Investigaci\u00f3n Cient\u00edfica, Facultad de Ciencias M\u00e9dicas, Universidad Nacional Aut\u00f3noma de Honduras (UNAH), Tegucigalpa, Honduras;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Buekens","sequence":"additional","affiliation":[{"name":"4Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Cafferata","sequence":"additional","affiliation":[{"name":"5Instituto de Efectividad Cl\u00ednica y Sanitaria, Buenos Aires, Argentina;"},{"name":"6Unidad de Investigaci\u00f3n Cl\u00ednica y Epidemiol\u00f3gica, Montevideo, Uruguay;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zulma","family":"Alvarez","sequence":"additional","affiliation":[{"name":"7Unidad de Vigilancia de la Salud, Regi\u00f3n Sanitaria Metropolitana del Distrito Central (RSMDC), Secretar\u00eda de Salud de Honduras, Tegucigalpa, Honduras;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mabel","family":"Berrueta","sequence":"additional","affiliation":[{"name":"5Instituto de Efectividad Cl\u00ednica y Sanitaria, Buenos Aires, Argentina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Bock","sequence":"additional","affiliation":[{"name":"8Direcci\u00f3n General, RSMDC, Secretar\u00eda de Salud de Honduras, Tegucigalpa, Honduras;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Bustillo","sequence":"additional","affiliation":[{"name":"9Departamento de Ginecolog\u00eda y Obstetricia, Hospital Escuela, Tegucigalpa, Honduras;"},{"name":"10Departamento de Ginecolog\u00eda y Obstetricia, Facultad de Ciencias M\u00e9dicas, UNAH, Tegucigalpa, Honduras;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Calder\u00f3n","sequence":"additional","affiliation":[{"name":"11Centro de Salud Alonso Suazo, RSMDC, Secretar\u00eda de Salud de Honduras, Tegucigalpa, Honduras;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Callejas","sequence":"additional","affiliation":[{"name":"12Servicio de Neonatolog\u00eda, Departamento de Pediatr\u00eda, Hospital Escuela, Tegucigalpa, Honduras;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Castillo","sequence":"additional","affiliation":[{"name":"12Servicio de Neonatolog\u00eda, Departamento de Pediatr\u00eda, Hospital Escuela, Tegucigalpa, Honduras;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Ciganda","sequence":"additional","affiliation":[{"name":"6Unidad de Investigaci\u00f3n Cl\u00ednica y Epidemiol\u00f3gica, Montevideo, Uruguay;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"F\u00fanes","sequence":"additional","affiliation":[{"name":"12Servicio de Neonatolog\u00eda, Departamento de Pediatr\u00eda, Hospital Escuela, Tegucigalpa, Honduras;"},{"name":"13Departamento de Pediatr\u00eda, Facultad de Ciencias M\u00e9dicas, UNAH, Tegucigalpa, Honduras;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"1Departamento de Laboratorio Cl\u00ednico, Hospital Escuela, Tegucigalpa, Honduras;"},{"name":"2Instituto de Enfermedades Infecciosas y Parasitolog\u00eda Antonio Vidal, Tegucigalpa, Honduras;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"14Centro de Investigaciones Gen\u00e9ticas, Instituto de Investigaciones en Microbiolog\u00eda, Facultad de Ciencias, UNAH, Tegucigalpa, Honduras;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz","family":"Gibbons","sequence":"additional","affiliation":[{"name":"5Instituto de Efectividad Cl\u00ednica y Sanitaria, Buenos Aires, Argentina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M.","family":"Gilboa","sequence":"additional","affiliation":[{"name":"15Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily W.","family":"Harville","sequence":"additional","affiliation":[{"name":"4Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"16Departamento de Pediatr\u00eda, Hospital de Especialidades San Felipe, Tegucigalpa, Honduras;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"2Instituto de Enfermedades Infecciosas y Parasitolog\u00eda Antonio Vidal, Tegucigalpa, Honduras;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"1Departamento de Laboratorio Cl\u00ednico, Hospital Escuela, Tegucigalpa, Honduras;"},{"name":"2Instituto de Enfermedades Infecciosas y Parasitolog\u00eda Antonio Vidal, Tegucigalpa, Honduras;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivette","family":"Lorenzana","sequence":"additional","affiliation":[{"name":"14Centro de Investigaciones Gen\u00e9ticas, Instituto de Investigaciones en Microbiolog\u00eda, Facultad de Ciencias, UNAH, Tegucigalpa, Honduras;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Tulio Luque","sequence":"additional","affiliation":[{"name":"17Servicio de Infectolog\u00eda, Departamento de Pediatr\u00eda, Hospital Escuela, Tegucigalpa, Honduras;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Maldonado","sequence":"additional","affiliation":[{"name":"18Servicio de Oftalmolog\u00eda, Departamento de Pediatr\u00eda, Hospital Escuela, Tegucigalpa, Honduras;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia A.","family":"Moore","sequence":"additional","affiliation":[{"name":"15Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Ochoa","sequence":"additional","affiliation":[{"name":"19Servicio de Maternidad, Hospital de Especialidades San Felipe, Tegucigalpa, Honduras;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leda","family":"Parham","sequence":"additional","affiliation":[{"name":"14Centro de Investigaciones Gen\u00e9ticas, Instituto de 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