{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:22:20Z","timestamp":1775265740352,"version":"3.50.1"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,7]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p>Disseminated histoplasmosis is the most frequent acquired immunodeficiency syndrome\u2013defining illness in French Guiana. Paradoxically, central nervous system (CNS) involvement has been scarcely described. We aimed to identify CNS histoplasmosis in our territory. We conducted an observational, multicentric, descriptive, and retrospective study including patients with proven or probable CNS histoplasmosis according to the European Organization for Research and Treatment of Cancer\/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC\/MGS). The study population consisted of patients admitted in one of the hospitals of French Guiana between January 1, 1990 and December 31, 2019. During the study period, 390 cases of HIV-associated histoplasmosis were recorded, in which six of them had CNS infections with <jats:italic>Histoplasma capsulatum<\/jats:italic>. The male to female sex ratio was 0.25, and the median age at diagnosis was 37.5 years. The median CD4 count was 42 cells\/mm<jats:sup>3<\/jats:sup> ([IQR: 29\u201360]). All patients had disseminated histoplasmosis. Usual signs of meningitis were observed in three patients and focal signs in four patients. One patient had no neurological signs. The median time between the first cerebral symptoms and diagnosis was 22.4 days (IQR 9.5\u201336.2). Two patients died within a month after diagnosis. In conclusion, few proven CNS localizations of histoplasmosis were observed on 30-year study in French Guiana. This low proportion suggests that the documentation of CNS involvement is often not ascertained for lack of awareness of this particular presentation, and for lack of rapid and sensitive diagnostic tools.<\/jats:p>","DOI":"10.4269\/ajtmh.20-1486","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T15:35:16Z","timestamp":1620660916000},"page":"125-129","source":"Crossref","is-referenced-by-count":9,"title":["Histoplasmosis of the Central Nervous System: A Case Series between 1990 and 2019 in French Guiana"],"prefix":"10.4269","volume":"105","author":[{"given":"Lo\u00efc","family":"Epelboin","sequence":"first","affiliation":[{"name":"1Infectious Diseases Department, Centre Hospitalier de Cayenne, Cayenne, French Guiana;"},{"name":"2CIC INSERM 1424, Centre Hospitalier de Cayenne, Cayenne, French Guiana;"},{"name":"3Ecosyst\u00e8mes Amazoniens et Pathologie Tropicale, EA3593, Universit\u00e9 de Guyane, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A\u00efda","family":"Dione","sequence":"additional","affiliation":[{"name":"1Infectious Diseases Department, Centre Hospitalier de Cayenne, Cayenne, French Guiana;"},{"name":"4Centre Gratuit D\u2019Information de D\u00e9pistage et de Diagnostic, Centre Hospitalier Agen Nerac - H\u00f4pital Saint-Esprit, Agen, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Serris","sequence":"additional","affiliation":[{"name":"5Universit\u00e9 Paris Descartes, Centre D\u2019Infectiologie Necker Pasteur, IHU Imagine, H\u00f4pital Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Paris, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Blanchet","sequence":"additional","affiliation":[{"name":"6Laboratory of Parasitology and Mycology, University of French Guiana, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastien","family":"Bidaud","sequence":"additional","affiliation":[{"name":"1Infectious Diseases Department, Centre Hospitalier de Cayenne, Cayenne, French Guiana;"},{"name":"7Health Centres for Remote Areas, Andr\u00e9e Rosemon Hospital, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u00eblle","family":"Walter","sequence":"additional","affiliation":[{"name":"1Infectious Diseases Department, Centre Hospitalier de Cayenne, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Abboud","sequence":"additional","affiliation":[{"name":"1Infectious Diseases Department, Centre Hospitalier de Cayenne, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Mosnier","sequence":"additional","affiliation":[{"name":"1Infectious Diseases Department, Centre Hospitalier de Cayenne, Cayenne, French Guiana;"},{"name":"7Health Centres for Remote Areas, Andr\u00e9e Rosemon Hospital, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9lanie","family":"Gaillet","sequence":"additional","affiliation":[{"name":"7Health Centres for Remote Areas, Andr\u00e9e Rosemon Hospital, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Michaud","sequence":"additional","affiliation":[{"name":"7Health Centres for Remote Areas, Andr\u00e9e Rosemon Hospital, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Couppi\u00e9","sequence":"additional","affiliation":[{"name":"8Dermatology Department, Andr\u00e9e Rosemon Hospital, Cayenne, French Guiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magalie","family":"Demar","sequence":"additional","affiliation":[{"name":"3Ecosyst\u00e8mes Amazoniens et Pathologie Tropicale, EA3593, Universit\u00e9 de Guyane, Cayenne, French Guiana;"},{"name":"6Laboratory of Parasitology and Mycology, University of French Guiana, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Nacher","sequence":"additional","affiliation":[{"name":"2CIC INSERM 1424, Centre Hospitalier de Cayenne, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix","family":"Djossou","sequence":"additional","affiliation":[{"name":"1Infectious Diseases Department, Centre Hospitalier de Cayenne, Cayenne, French Guiana;"},{"name":"3Ecosyst\u00e8mes Amazoniens et Pathologie Tropicale, EA3593, Universit\u00e9 de Guyane, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Adenis","sequence":"additional","affiliation":[{"name":"2CIC INSERM 1424, Centre Hospitalier de Cayenne, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/1\/article-p125.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/105\/1\/article-p125.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:42:03Z","timestamp":1628728923000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/1\/article-p125.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,7]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.20-1486","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,7]]}}}