{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:22:23Z","timestamp":1784910143320,"version":"3.55.0"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>As part of a phase 4, randomized, double-blind, placebo-controlled trial to assess the immunogenicity and safety of PXVX0200 in children and adolescents aged 2\u201317 years, a subset of 73 adolescent subjects aged 12\u201317 years was followed for 2 years after vaccination and had blood collected for antibody assays on days 1, 11, 29, 91, 181, 365, 547, and 730. Endpoints included serum vibriocidal antibody (SVA) seroconversion, defined as a 4-fold or greater rise in antibody titer over baseline; geometric mean titers (GMTs); and geometric mean fold increase (GMFI) over baseline. Serum vibriocidal antibody seroconversion persisted in most subjects, with a rate of 64.5% noted at day 730. Geometric mean titers and GMFI both peaked at day 11 and remained greater than baseline at all time points, including day 730. Vaccination with PXVX0200 produces an immune response which persists for at least 2 years in adolescents aged 12\u201317 years.<\/jats:p>","DOI":"10.4269\/ajtmh.20-1576","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T14:54:30Z","timestamp":1617634470000},"page":"1758-1760","source":"Crossref","is-referenced-by-count":10,"title":["Long-Term Immunogenicity of Live Oral Cholera Vaccine CVD 103-HgR in Adolescents Aged 12\u201317 Years in the United States"],"prefix":"10.4269","volume":"104","author":[{"given":"James M.","family":"McCarty","sequence":"first","affiliation":[{"name":"1Stanford University School of Medicine, Stanford, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cassie","sequence":"additional","affiliation":[{"name":"2Emergent BioSolutions Canada, Inc., Winnipeg, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Bedell","sequence":"additional","affiliation":[{"name":"3Emergent Travel Health, Inc., Redwood City, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Lock","sequence":"additional","affiliation":[{"name":"3Emergent Travel Health, Inc., Redwood City, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Bennett","sequence":"additional","affiliation":[{"name":"3Emergent Travel Health, Inc., Redwood City, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/5\/article-p1758.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/104\/5\/article-p1758.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T20:41:52Z","timestamp":1629924112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/5\/article-p1758.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,5]]},"references-count":0,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.20-1576","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,5]]}}}