{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:47:37Z","timestamp":1791920857710,"version":"4.3.4"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>HIV prevalence in Indonesia is increasing, and only 64% of infected individuals know their status. In a prospective cohort of 1,453 hospitalized patients with unexplained fever, 46 (3.2%) had HIV, including 15 (1.1%) patients without a prior HIV diagnosis. Among 31 subjects previously known to have HIV, 21 (68%) had been receiving combination antiretroviral therapy (cART) at the time of enrollment. Of 39 HIV cases with HIV RNA levels \u2265\u2009100 copies\/mL, sequencing for genotype analysis and resistance testing was successful in 30 (77%) subjects. The most common HIV subtypes were AE (90%) and B (10%). Five (16.7%) subjects had resistance mutations to nucleoside and non-nucleoside reverse transcriptase inhibitors, and all of them were on cART. No evidence of transmitted drug resistance was found in newly diagnosed individuals. Hospital-based screening may be an efficient method to expand HIV testing and identify a significant number of new cases. Access to care, close monitoring, expansion of anti-retroviral options, and ensuring availability of CD4 determinations, viral load testing, and genotyping are crucial to control of the epidemic in Indonesia.<\/jats:p>","DOI":"10.4269\/ajtmh.20-1595","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T09:14:44Z","timestamp":1630314884000},"page":"960-965","source":"Crossref","is-referenced-by-count":14,"title":["Prevalence of HIV Infection and Resistance Mutations in Patients Hospitalized for Febrile Illness in Indonesia"],"prefix":"10.4269","volume":"105","author":[{"given":"Tuti P.","family":"Merati","sequence":"first","affiliation":[{"name":"1Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Karyana","sequence":"additional","affiliation":[{"name":"2National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia;"},{"name":"3Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliana","family":"Tjitra","sequence":"additional","affiliation":[{"name":"2National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Kosasih","sequence":"additional","affiliation":[{"name":"3Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abu T.","family":"Aman","sequence":"additional","affiliation":[{"name":"4Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bachti","family":"Alisjahbana","sequence":"additional","affiliation":[{"name":"5Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewi","family":"Lokida","sequence":"additional","affiliation":[{"name":"6Department of Clinical Pathology, Tangerang District Hospital, Tangerang, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dona","family":"Arlinda","sequence":"additional","affiliation":[{"name":"2National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia;"},{"name":"3Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Maldarelli","sequence":"additional","affiliation":[{"name":"7National Cancer Institute, National Institutes of Health, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Neal","sequence":"additional","affiliation":[{"name":"8National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansyur","family":"Arif","sequence":"additional","affiliation":[{"name":"9Faculty of Medicine, Universitas Hasanudin, Makassar, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Hussein","family":"Gasem","sequence":"additional","affiliation":[{"name":"10Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurhayati","family":"Lukman","sequence":"additional","affiliation":[{"name":"3Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratiwi","family":"Sudarmono","sequence":"additional","affiliation":[{"name":"11Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuen-Yen","family":"Lau","sequence":"additional","affiliation":[{"name":"7National Cancer Institute, National Institutes of Health, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman","family":"Hadi","sequence":"additional","affiliation":[{"name":"12Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivi","family":"Lisdawati","sequence":"additional","affiliation":[{"name":"13Sulianti Saroso, Infectious Disease Hospital, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahyu Nawang","family":"Wulan","sequence":"additional","affiliation":[{"name":"3Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Clifford","family":"Lane","sequence":"additional","affiliation":[{"name":"8National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"8National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/4\/article-p960.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/105\/4\/article-p960.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T14:40:35Z","timestamp":1633531235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/4\/article-p960.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,6]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.20-1595","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,6]]}}}