{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T16:58:14Z","timestamp":1726851494568},"reference-count":39,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Scrub typhus is an acute febrile, mite-borne disease endemic to the Asia\u2013Pacific region. In South Korea, it is a seasonal disease that occurs frequently in the autumn, and its incidence has increased steadily. In this study, we used a liquid chromatography and flow injection analysis\u2013tandem mass spectrometry-based targeted urine metabolomics approach to evaluate the host response to <jats:italic>Orientia tsutsugamushi<\/jats:italic> infection. Balb\/c mice were infected with <jats:italic>O. tsutsugamushi<\/jats:italic> Boryong, and their urine metabolite profile was examined. Metabolites that differed significantly between the experimental groups were identified using the Kruskal\u2013Wallis test. Sixty-five differential metabolites were identified. The principal metabolite classes were acylcarnitines, glycerophospholipids, biogenic amines, and amino acids. An ingenuity pathway analysis revealed that several toxic (cardiotoxic, hepatotoxic, and nephrotoxic) metabolites are induced by scrub typhus infection. This is the first report of urinary metabolite biomarkers of scrub typhus infection and it enhances our understanding of the metabolic pathways involved.<\/jats:p>","DOI":"10.4269\/ajtmh.20-1608","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T14:37:38Z","timestamp":1673275058000},"page":"296-304","source":"Crossref","is-referenced-by-count":1,"title":["Urine Metabolite of Mice with Orientia tsutsugamushi Infection"],"prefix":"10.4269","volume":"108","author":[{"given":"Sangho","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Zoonotic and Vector Borne Disease Research, Center for Infectious Disease Research, National Institute of Infectious Disease, National Institute of Health, Korea Disease Control and Prevention Agency, Osong-eup, Cheongju-si, Chungcheongbuk-do, 28160, Republic of 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