{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T12:41:11Z","timestamp":1771850471533,"version":"3.50.1"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus endemic in many areas around the world. HTLV-1 can induce the development of adult T-cell leukemia (ATL) or myelopathy\/tropical spastic paraparesis (HAM\/TSP). We report a patient who presented to our outpatient clinic with massive splenomegaly, weight loss, urinary retention, and lower extremity weakness for the previous 3 years. The patient was found to have positive HTLV-1 by ELISA and Western blot from peripheral blood. Evaluation of the spleen demonstrated T-cell large granular lymphocyte leukemia consistent with ATL. In addition to progressive lower extremity weakness, hyperreflexia and clonus, cerebral spinal fluid was positive for HTLV-1 by ELISA and had a reversed CD4-to-CD8 ratio consistent with HAM\/TSP. These findings suggest HTLV-1 induced ATL and HAM\/TSP presenting simultaneously in the same patient.<\/jats:p>","DOI":"10.4269\/ajtmh.20-1656","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T14:21:02Z","timestamp":1632147662000},"page":"1298-1300","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: HTLV-1\u2013Induced Adult T-Cell Leukemia and Tropical Spastic Paresis"],"prefix":"10.4269","volume":"105","author":[{"given":"Reece","family":"Rosenthal","sequence":"first","affiliation":[{"name":"1Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julika","family":"Kaplan","sequence":"additional","affiliation":[{"name":"1Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"2Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Mims","sequence":"additional","affiliation":[{"name":"3Department of Hematology\/Oncology, Baylor College of Medicine, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill E.","family":"Weatherhead","sequence":"additional","affiliation":[{"name":"1Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas;"},{"name":"4National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas;"},{"name":"5Department of Pediatrics, Section of Tropical Medicine, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/5\/article-p1298.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/105\/5\/article-p1298.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T14:33:07Z","timestamp":1635949987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/5\/article-p1298.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,3]]},"references-count":0,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.20-1656","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,3]]}}}