{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:33:41Z","timestamp":1791498821213,"version":"4.3.4"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,2]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p>Artesunate therapy for severe malaria syndromes has been associated with post-treatment hemolysis and anemia. We defined post-malaria anemia as any decrease in hematocrit between the index hospitalization for severe malaria and 1 month after. We determined the incidence and severity of post-malaria anemia in Malawian children surviving cerebral malaria (CM) by analyzing hospital and follow-up data from a long-standing study of CM pathogenesis. Children enrolled before 2014 and treated with quinine (<jats:italic>N<\/jats:italic> = 258) were compared with those admitted in 2014 and after, and treated with artesunate (<jats:italic>N<\/jats:italic> = 235). The last hematocrit value obtained during hospitalization was compared with the 1-month post-hospitalization hematocrit value. The overall rate of a post-hospitalization decrease in hematocrit in children surviving CM was 5.3% (11 of 235 or 4.7% for quinine, 15 of 258 or 5.8% for artesunate; odds ratio, 3.23 [0.88, 18.38]); no patients with a decrease in hematocrit were symptomatic, and none required transfusion after hospitalization. Of the 26 children who had a decrease in hematocrit 1 month after hospitalization, 23.1% had evidence of a new malaria infection. When children treated with quinine and artesunate were combined, a higher hematocrit level on admission, lower quantitative histidine-rich protein level, and splenomegaly were associated independently with post-malaria anemia. In African survivors of CM, post-malaria anemia is rare, mild, and unassociated with the anti-malarial treatment received.<\/jats:p>","DOI":"10.4269\/ajtmh.20-1668","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T13:27:29Z","timestamp":1619443649000},"page":"2146-2151","source":"Crossref","is-referenced-by-count":2,"title":["Post-Malaria Anemia Is Rare in Malawian Children with Cerebral Malaria"],"prefix":"10.4269","volume":"104","author":[{"given":"Geoffrey","family":"Guenther","sequence":"first","affiliation":[{"name":"1Department of Pediatrics, Children\u2019s National Medical Center, Washington, District of Columbia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexuse M.","family":"Saidi","sequence":"additional","affiliation":[{"name":"2Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Izem","sequence":"additional","affiliation":[{"name":"3Division of Biostatistics and Study Methodology, Children\u2019s National Research Institute, Washington, District of Columbia;"},{"name":"4Division of Epidemiology, The George Washington University School of Public Health, Washington, District of Columbia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Seydel","sequence":"additional","affiliation":[{"name":"2Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi;"},{"name":"5Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas G.","family":"Postels","sequence":"additional","affiliation":[{"name":"2Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi;"},{"name":"6Division of Neurology, The George Washington University\/Children\u2019s National Medical Center, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/6\/article-p2146.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/104\/6\/article-p2146.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T16:40:14Z","timestamp":1622652014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/6\/article-p2146.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,2]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.20-1668","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,2]]}}}