{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T07:59:59Z","timestamp":1778399999086,"version":"3.51.4"},"reference-count":31,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Trop Med Hyg"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:p>A total of 1,345 <jats:italic>Ixodes persulcatus<\/jats:italic> ticks collected from northeastern China were investigated for the presence of <jats:italic>Anaplasma phagocytophila<\/jats:italic> and <jats:italic>Borrelia burgdorferi<\/jats:italic> by a nested polymerase chain reaction (PCR). Sixty-two (4.6%) ticks were positive for <jats:italic>A. phagocytophila<\/jats:italic> and 454 (33.8%) were positive for <jats:italic>B. burgdorferi<\/jats:italic>. Seven (0.5%) were coinfected with both agents. Sequence analysis of 919-basepair PCR amplicons revealed three types of <jats:italic>A. phagocytophila<\/jats:italic>. Type 1 was identical to the published sequences of <jats:italic>A. phagocytophila<\/jats:italic>s responsible for human granulocytic ehrlichiosis (HGE). The other two variants differed from the HGE agent sequence at one and four positions, respectively. These findings imply that infection with <jats:italic>A. phagocytophila<\/jats:italic> poses a potential health threat to both humans and animals in northeastern China, and that ehrlichiosis should be considered in the differential diagnosis of febrile patients with a history of tick bite, particularly when clinical manifestations are atypical for Lyme disease.<\/jats:p>","DOI":"10.4269\/ajtmh.2003.68.547","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T17:38:51Z","timestamp":1494437931000},"page":"547-550","source":"Crossref","is-referenced-by-count":80,"title":["PREVALENCE OF ANAPLASMA PHAGOCYTOPHILA AND BORRELIA BURGDORFERI IN IXODES PERSULCATUS TICKS FROM NORTHEASTERN CHINA"],"prefix":"10.4269","volume":"68","author":[{"given":"WU-CHUN","family":"CAO","sequence":"first","affiliation":[{"name":"Deparment of Epidemiology, Beijing Institute of Microbiology and Epidemiology, Beijing, People\u2019s Republic of China; Center for Decision Sciences in Tropical Disease Control, Department of Public Health, Erasmus University Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"QIU-MIN","family":"ZHAO","sequence":"additional","affiliation":[{"name":"Deparment of Epidemiology, Beijing Institute of Microbiology and Epidemiology, Beijing, People\u2019s Republic of China; Center for Decision Sciences in Tropical Disease Control, Department of Public Health, Erasmus University Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAN-HE","family":"ZHANG","sequence":"additional","affiliation":[{"name":"Deparment of Epidemiology, Beijing Institute of Microbiology and Epidemiology, Beijing, People\u2019s Republic of China; Center for Decision Sciences in Tropical Disease Control, Department of Public Health, Erasmus University Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HONG","family":"YANG","sequence":"additional","affiliation":[{"name":"Deparment of Epidemiology, Beijing Institute of Microbiology and Epidemiology, Beijing, People\u2019s Republic of China; Center for Decision Sciences in Tropical Disease Control, Department of Public Health, Erasmus University Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIAO-MING","family":"WU","sequence":"additional","affiliation":[{"name":"Deparment of Epidemiology, Beijing Institute of Microbiology and Epidemiology, Beijing, People\u2019s Republic of China; Center for Decision Sciences in Tropical Disease Control, Department of Public Health, Erasmus University Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BO-HAI","family":"WEN","sequence":"additional","affiliation":[{"name":"Deparment of Epidemiology, Beijing Institute of Microbiology and Epidemiology, Beijing, People\u2019s Republic of China; Center for Decision Sciences in Tropical Disease Control, Department of Public Health, Erasmus University Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XI-TAN","family":"ZHANG","sequence":"additional","affiliation":[{"name":"Deparment of Epidemiology, Beijing Institute of Microbiology and Epidemiology, Beijing, People\u2019s Republic of China; Center for Decision Sciences in Tropical Disease Control, Department of Public Health, Erasmus University Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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