{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T23:30:14Z","timestamp":1769815814642,"version":"3.49.0"},"reference-count":31,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Trop Med Hyg"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:p>In October 2000, 71,187 persons were treated for lymphatic filariasis using albendazole and diethylcar-bamazine (DEC) or DEC alone in Leogane, Haiti. We documented the frequency of adverse reactions, severity and cost of treatment. Adverse reactions were classified as minor, moderate, or severe. Overall, 24% (17,421) of the treated persons reported one or more adverse reactions. There were 15,916 (91%) minor and 1502 (9%) moderate adverse reaction reports. Men outnumbered women 2:1 in reporting moderate problems. Three patients, representing roughly one in 25,000 persons treated, were hospitalized with severe adverse reactions judged to be treatment-associated by physician review. The cost per person treated for adverse reactions was more than twice the cost per person treated for lymphatic filariasis ($1.60 versus $0.71). Severe adverse reactions to lymphatic filariasis treatment using DEC with or without albendazole are uncommon. Minor and moderate reactions are more commonly reported and their management represents a challenge to lymphatic filariasis elimination programs.<\/jats:p>","DOI":"10.4269\/ajtmh.2003.68.568","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T17:38:51Z","timestamp":1494437931000},"page":"568-573","source":"Crossref","is-referenced-by-count":44,"title":["FREQUENCY, SEVERITY, AND COSTS OF ADVERSE REACTIONS FOLLOWING MASS TREATMENT FOR LYMPHATIC FILARIASIS USING DIETHYLCARBAMAZINE AND ALBENDAZOLE IN LEOGANE, HAITI, 2000"],"prefix":"10.4269","volume":"68","author":[{"given":"STEVEN I.","family":"McLAUGHLIN","sequence":"first","affiliation":[{"name":"Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Hopital Sainte Croix, Leogane, Haiti; Department of Family and Preventative Medicine, University of South Carolina School of Medicine, Columbia, South Carolina; Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEANNE","family":"RADDAY","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Hopital Sainte Croix, Leogane, Haiti; Department of Family and Preventative Medicine, University of South Carolina School of Medicine, Columbia, South Carolina; Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIE CARMEL","family":"MICHEL","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Hopital Sainte Croix, Leogane, Haiti; Department of Family and Preventative Medicine, University of South Carolina School of Medicine, Columbia, South Carolina; Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID G.","family":"ADDISS","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Hopital Sainte Croix, Leogane, Haiti; Department of Family and Preventative Medicine, University of South Carolina School of Medicine, Columbia, South Carolina; Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL J.","family":"BEACH","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Hopital Sainte Croix, Leogane, Haiti; Department of Family and Preventative Medicine, University of South Carolina School of Medicine, Columbia, South Carolina; Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PATRICK J.","family":"LAMMIE","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Hopital Sainte Croix, Leogane, Haiti; Department of Family and Preventative Medicine, University of South Carolina School of Medicine, Columbia, South Carolina; Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN","family":"LAMMIE","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Hopital Sainte Croix, Leogane, Haiti; Department of Family and Preventative Medicine, University of South Carolina School of Medicine, Columbia, South Carolina; Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"RHEINGANS","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Hopital Sainte Croix, Leogane, Haiti; Department of Family and Preventative Medicine, University of South Carolina School of Medicine, Columbia, South Carolina; Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JACK","family":"LAFONTANT","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Hopital Sainte Croix, Leogane, Haiti; Department of Family and Preventative Medicine, University of South Carolina School of Medicine, Columbia, South Carolina; Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Parasitology","first-page":"409","volume":"112","year":"1996"},{"key":"R2","year":"1997"},{"key":"R3","series-title":"Bull World Health Organ","first-page":"491","volume":"75","year":"1997"},{"key":"R4","series-title":"J Commun Dis","first-page":"317","volume":"18","year":"1986"},{"key":"R5","year":"1997"},{"key":"R6","series-title":"Lancet","first-page":"1677","volume":"359","year":"2002"},{"key":"R7","year":"1998"},{"key":"R8","series-title":"Rev Infect Dis","first-page":"341","volume":"7","year":"1985"},{"key":"R9","series-title":"Trans R Soc Trop Med Hyg","first-page":"94","volume":"92","year":"1998"},{"key":"R10","series-title":"Trans R Soc Trop Med Hyg","first-page":"232","volume":"88","year":"1994"},{"key":"R11","series-title":"Am J Trop Med Hyg","first-page":"3","volume":"44","year":"1991"},{"key":"R12","series-title":"Lancet","first-page":"480","volume":"350","year":"1997"},{"key":"R13","series-title":"J Urol","first-page":"409","volume":"156","year":"1996"},{"key":"R14","series-title":"Trans R Soc Trop Med Hyg","first-page":"192","volume":"90","year":"1996"},{"key":"R15","series-title":"Trop Biomed","first-page":"19","volume":"10","year":"1993"},{"key":"R16","series-title":"Trans R Soc Trop Med Hyg","first-page":"332","volume":"95","year":"2001"},{"key":"R17","series-title":"Trop Doct","first-page":"178","volume":"30","year":"2000"},{"key":"R18","series-title":"J Infect Dis","first-page":"1178","volume":"167","year":"1993"},{"key":"R19","series-title":"Parasitology","first-page":"S147","volume":"121","year":"2000"},{"key":"R20","series-title":"Parasitol Today","first-page":"382","volume":"15","year":"1999"},{"key":"R21","series-title":"J Nutr","first-page":"1036","volume":"123","year":"1993"},{"key":"R22","series-title":"Am J Trop Med Hyg","first-page":"479","volume":"60","year":"1999"},{"key":"R23","series-title":"Trans R Soc Trop Med Hyg","first-page":"78","volume":"91","year":"1997"},{"key":"R24","series-title":"Trans R Soc Trop Med Hyg","first-page":"441","volume":"89","year":"1995"},{"key":"R25","series-title":"Trans R Soc Trop Med Hyg","first-page":"205","volume":"94","year":"2000"},{"key":"R26","series-title":"Ann Trop Med Parasitol","first-page":"643","volume":"93","year":"1999"},{"key":"R27","series-title":"Arch Dis Child","first-page":"399","volume":"65","year":"1990"},{"key":"R28","year":"1994"},{"key":"R29","year":"1994"},{"key":"R30","series-title":"Lancet","first-page":"1145","volume":"353","year":"1999"},{"key":"R31","series-title":"Trans R Soc Trop Med Hyg","first-page":"72","volume":"95","year":"2001"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/68\/5\/article-p568.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/68\/5\/article-p568.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/68\/5\/article-p568.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T16:54:46Z","timestamp":1725382486000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/68\/5\/article-p568.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5]]},"references-count":31,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.2003.68.568","relation":{},"ISSN":["0002-9637"],"issn-type":[{"value":"0002-9637","type":"print"}],"subject":[],"published":{"date-parts":[[2003,5]]}}}