{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:28:03Z","timestamp":1790936883435,"version":"4.1.0"},"reference-count":18,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Trop Med Hyg"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:p>Malaria and leptospirosis are both common in the tropics. Simultaneous infections are possible, although not previously reported. We report two cases of malaria from an area of Thailand on the Thailand-Myanmar border with compelling serologic evidence of simultaneous acute leptospirosis. One was a case of infection with <jats:italic>Plasmodium falciparum<\/jats:italic> with acute and convalescent microscopic agglutination test (MAT) titers for <jats:italic>Leptospira<\/jats:italic> serovar icterohaemorrhagiae of 1:200 and 1:1,600, respectively. The other was a case of infection with <jats:italic>P. vivax<\/jats:italic> that seroconverted to a titer of 1:3,200 for <jats:italic>Leptospira<\/jats:italic> serovar bataviae. Additionally, there were five probable cases of leptospirosis with patent malaria parasitemia (three <jats:italic>P. falciparum<\/jats:italic> and two <jats:italic>P. vivax<\/jats:italic>) detected. Management of dual infections is complicated by their similar clinical presentations, and because the confirmatory diagnosis of malaria is readily available as opposed to that of leptospirosis. Treatment focusing on malaria mono-infections instead of dual infections could result in a delay of specific therapy for leptospirosis and possible consequences of serious complications.<\/jats:p>","DOI":"10.4269\/ajtmh.2003.68.583","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T17:38:51Z","timestamp":1494437931000},"page":"583-585","source":"Crossref","is-referenced-by-count":37,"title":["CO-INFECTION WITH MALARIA AND LEPTOSPIROSIS"],"prefix":"10.4269","volume":"68","author":[{"given":"CHANSUDA","family":"WONGSRICHANALAI","sequence":"first","affiliation":[{"name":"Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center, Fort Sam Houston, San Antonio, Texas: Veterinary Command Food Analysis and Diagnostic Laboratory, Fort Sam Houston, San Antonio, Texas; Kwai River Christian Hospital, Sangkhlaburi, Kanchanaburi, Thailand; Walter Reed Army Institute of Research, Silver Spring, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CLINTON K.","family":"MURRAY","sequence":"additional","affiliation":[{"name":"Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center, Fort Sam Houston, San Antonio, Texas: Veterinary Command Food Analysis and Diagnostic Laboratory, Fort Sam Houston, San Antonio, Texas; Kwai River Christian Hospital, Sangkhlaburi, Kanchanaburi, Thailand; Walter Reed Army Institute of Research, Silver Spring, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHAEL","family":"GRAY","sequence":"additional","affiliation":[{"name":"Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center, Fort Sam Houston, San Antonio, Texas: Veterinary Command Food Analysis and Diagnostic Laboratory, Fort Sam Houston, San Antonio, Texas; Kwai River Christian Hospital, Sangkhlaburi, Kanchanaburi, Thailand; Walter Reed Army Institute of Research, Silver Spring, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. SCOTT","family":"MILLER","sequence":"additional","affiliation":[{"name":"Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center, Fort Sam Houston, San Antonio, Texas: Veterinary Command Food Analysis and Diagnostic Laboratory, Fort Sam Houston, San Antonio, Texas; Kwai River Christian Hospital, Sangkhlaburi, Kanchanaburi, Thailand; Walter Reed Army Institute of Research, Silver Spring, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PHILIP","family":"MCDANIEL","sequence":"additional","affiliation":[{"name":"Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center, Fort Sam Houston, San Antonio, Texas: Veterinary Command Food Analysis and Diagnostic Laboratory, Fort Sam Houston, San Antonio, Texas; Kwai River Christian Hospital, Sangkhlaburi, Kanchanaburi, Thailand; Walter Reed Army Institute of Research, Silver Spring, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WILSON J.","family":"LIAO","sequence":"additional","affiliation":[{"name":"Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center, Fort Sam Houston, San Antonio, Texas: Veterinary Command Food Analysis and Diagnostic Laboratory, Fort Sam Houston, San Antonio, Texas; Kwai River Christian Hospital, Sangkhlaburi, Kanchanaburi, Thailand; Walter Reed Army Institute of Research, Silver Spring, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AMY L.","family":"PICKARD","sequence":"additional","affiliation":[{"name":"Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center, Fort Sam Houston, San Antonio, Texas: Veterinary Command Food Analysis and Diagnostic Laboratory, Fort Sam Houston, San Antonio, Texas; Kwai River Christian Hospital, Sangkhlaburi, Kanchanaburi, Thailand; Walter Reed Army Institute of Research, Silver Spring, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALAN J.","family":"MAGILL","sequence":"additional","affiliation":[{"name":"Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center, Fort Sam Houston, San Antonio, Texas: Veterinary Command Food Analysis and Diagnostic Laboratory, Fort Sam Houston, San Antonio, Texas; Kwai River Christian Hospital, Sangkhlaburi, Kanchanaburi, Thailand; Walter Reed Army Institute of Research, Silver Spring, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Trans R Soc Trop Med Hyg","first-page":"76","volume":"72","year":"1978"},{"key":"R2","series-title":"Trans R Soc Trop Med Hyg","first-page":"21","volume":"92","year":"1998"},{"key":"R3","series-title":"Trans R Soc Trop Med Hyg","first-page":"310","volume":"94","year":"2000"},{"key":"R4","series-title":"Am J Trop Med Hyg","first-page":"112","volume":"62","year":"2000"},{"key":"R5","series-title":"Am J Trop Med Hyg","first-page":"657","volume":"65","year":"2001"},{"key":"R6","series-title":"Lancet","first-page":"1397","volume":"1","year":"1988"},{"key":"R7","series-title":"Scand J Infect Dis","first-page":"221","volume":"34","year":"2002"},{"key":"R8","series-title":"Braz J Infect Dis","first-page":"118","volume":"2","year":"1998"},{"key":"R9","series-title":"J Travel Med","first-page":"98","volume":"7","year":"2000"},{"key":"R10","series-title":"Infect Dis Clin North Am","first-page":"445","volume":"12","year":"1998"},{"key":"R11","series-title":"Trop Med Int Health","first-page":"124","volume":"5","year":"2000"},{"key":"R12","series-title":"J Clin Microbiol","first-page":"1464","volume":"40","year":"2002"},{"key":"R13","series-title":"Clin Microbiol Rev","first-page":"296","volume":"14","year":"2001"},{"key":"R14","year":"1988"},{"key":"R15","series-title":"Curr Opin Infect Dis","first-page":"527","volume":"14","year":"2001"},{"key":"R16","series-title":"Int J Infect Dis","first-page":"52","volume":"6","year":"2002"},{"key":"R17","series-title":"Am J Trop Med Hyg","first-page":"204","volume":"63","year":"2000"},{"key":"R18","series-title":"Southeast Asian J Trop Med Public Health","first-page":"155","volume":"33","year":"2002"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/68\/5\/article-p583.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/68\/5\/article-p583.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/68\/5\/article-p583.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T16:53:40Z","timestamp":1725382420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/68\/5\/article-p583.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5]]},"references-count":18,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.2003.68.583","relation":{},"ISSN":["0002-9637"],"issn-type":[{"value":"0002-9637","type":"print"}],"subject":[],"published":{"date-parts":[[2003,5]]}}}