{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T21:44:00Z","timestamp":1754603040447},"reference-count":26,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Trop Med Hyg"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>Although we have encountered many cases of monoclonal gammopathies (MGs) or oligoclonal gammopathies (OGs) in patients with <jats:italic>Orientia tsutsugamushi<\/jats:italic> infections, the clinical course of MG\/OG associated with these infections has rarely been reported. We serially monitored 18 cases of MG\/OG that appeared in the acute phase or early convalescent phase of scrub typhus. All MGs\/OGs associated with infection with <jats:italic>O. tsutsugamushi<\/jats:italic> disappeared 7\u201315 weeks after treatment with doxycycline. In three cases of scrub typhus, MGs\/OGs appeared before seropositive conversion (presence of antibodies against <jats:italic>O. tsutsugamushi<\/jats:italic>) and disappeared before seronegative conversion. Understanding our cases may be helpful for relevant clinical counseling and making appropriate medical decisions to avoid unnecessary invasive or cost-intensive diagnostic procedures for MGs\/OGs in scrub typhus, especially in disease-endemic areas. We also suggest that 2\u20134 months after antibiotic treatment might be the optimal follow-up time to observe the disappearance of MGs\/OGs associated with <jats:italic>O. tsutsugamushi<\/jats:italic> infections.<\/jats:p>","DOI":"10.4269\/ajtmh.2009.09-0063","type":"journal-article","created":{"date-parts":[[2009,10,9]],"date-time":"2009-10-09T17:32:47Z","timestamp":1255109567000},"page":"660-664","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Course of Monoclonal and Oligoclonal Gammopathies in Patients Infected with Orientia tsutsugamushi"],"prefix":"10.4269","volume":"81","author":[{"given":"Do-Sim","family":"Park","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Division of Infectious Disease, Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Republic of Korea; Department of Laboratory Medicine, Kunsan Medical Center, Wonkwang University School of Medicine, Iksan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Hyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Division of Infectious Disease, Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Republic of Korea; Department of Laboratory Medicine, Kunsan Medical Center, Wonkwang University School of Medicine, Iksan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Division of Infectious Disease, Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Republic of Korea; Department of Laboratory Medicine, Kunsan Medical Center, Wonkwang University School of Medicine, Iksan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Key-Earn","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Division of Infectious Disease, Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Republic of Korea; Department of Laboratory Medicine, Kunsan Medical Center, Wonkwang University School of Medicine, Iksan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Br J Haematol","first-page":"730","volume":"139","year":"2007"},{"key":"R2","series-title":"Clin Lymphoma Myeloma","first-page":"102","volume":"6","year":"2005"},{"key":"R3","series-title":"Am J Hematol","first-page":"273","volume":"73","year":"2003"},{"key":"R4","series-title":"Korean J Lab Med","first-page":"116","volume":"29","year":"2009"},{"key":"R5","series-title":"Proc Soc Exp Biol Med","first-page":"568","volume":"112","year":"1963"},{"key":"R6","series-title":"J Infect","first-page":"44","volume":"56","year":"2008"},{"key":"R7","series-title":"J Assoc Physicians India","first-page":"291","volume":"54","year":"2006"},{"key":"R8","series-title":"Infect Dis Clin North Am","first-page":"997","volume":"21","year":"2007"},{"key":"R9","series-title":"Leukemia","first-page":"2150","volume":"11","year":"1997"},{"key":"R10","series-title":"Clin Infect Dis","first-page":"1198","volume":"43","year":"2006"},{"key":"R11","series-title":"Leuk Lymphoma","first-page":"1067","volume":"46","year":"2005"},{"key":"R12","series-title":"Br J Haematol","first-page":"685","volume":"136","year":"2007"},{"key":"R13","series-title":"J Clin Pathol","first-page":"1365","volume":"60","year":"2007"},{"key":"R14","series-title":"J Gastroenterol Hepatol","first-page":"459","volume":"18","year":"2003"},{"key":"R15","series-title":"Autoimmun Rev","first-page":"581","volume":"6","year":"2007"},{"key":"R16","series-title":"Semin Liver Dis","first-page":"143","volume":"20","year":"2000"},{"key":"R17","series-title":"J Immunol","first-page":"2533","volume":"154","year":"1995"},{"key":"R18","series-title":"Jap J Med","first-page":"64","volume":"22","year":"1983"},{"key":"R19","series-title":"Am J Hematol","first-page":"115","volume":"81","year":"2006"},{"key":"R20","series-title":"Ann Hematol","first-page":"455","volume":"82","year":"2003"},{"key":"R21","series-title":"Br J Haematol","first-page":"391","volume":"81","year":"1992"},{"key":"R22","series-title":"Rev Clin Esp","first-page":"288","volume":"208","year":"2008"},{"key":"R23","series-title":"Nature","first-page":"711","volume":"220","year":"1968"},{"key":"R24","series-title":"Acta Pathol Microbiol Scand","first-page":"303","volume":"65","year":"1965"},{"key":"R25","series-title":"N Engl J Med","first-page":"1817","volume":"328","year":"1993"},{"key":"R26","series-title":"Clin Chem","first-page":"973","volume":"34","year":"1988"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/81\/4\/article-p660.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/81\/4\/article-p660.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/81\/4\/article-p660.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T14:48:09Z","timestamp":1725288489000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/81\/4\/article-p660.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":26,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.2009.09-0063","relation":{},"ISSN":["0002-9637"],"issn-type":[{"type":"print","value":"0002-9637"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}