{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:10:53Z","timestamp":1779084653653,"version":"3.51.4"},"reference-count":18,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Trop Med Hyg"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>Although the yellow fever 17D strain live-attenuated vaccine has been widely used over the past seven decades with a long history of safe records, recent reports of serious, sometimes fatal, adverse events, raised concerns about its tolerance. We extracted all cases of serious neurologic adverse events that occurred within 30 days of yellow fever vaccination in our institution during 2000\u20132008. Four cases (meningitis, n = 2 and meningo-encephalitis, n = 2) were identified. The male:female ratio was 3:1, and ages ranged from 21 to 55 years. Cerebrospinal fluid examination showed pleocytosis (10\u201382 cells\/mm<jats:sup>3<\/jats:sup>, 64\u201384% lymphocytes), with slightly elevated protein levels (0.4\u20130.68 g\/L). All symptoms resolved in three patients, but attention disorder and cerebellar syndrome persisted in one patient (at six months follow-up). The incidence of yellow fever vaccine\u2013associated serious neurologic events was estimated to be 9.9\/100,000 vaccine doses (95% confidence interval = 2.7\u201325.4\/100,000) in this study, which was 10 times higher than previous estimates that did not include acute meningitis.<\/jats:p>","DOI":"10.4269\/ajtmh.2009.09-0295","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T22:29:10Z","timestamp":1260311350000},"page":"1141-1143","source":"Crossref","is-referenced-by-count":31,"title":["Incidence of Yellow Fever Vaccine-Associated Neurotropic Disease"],"prefix":"10.4269","volume":"81","author":[{"given":"Thomas","family":"Guimard","sequence":"first","affiliation":[{"name":"Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, Rennes, France; Virology, Pontchaillou University Hospital, Rennes, France; Pharmacovigilance, Pontchaillou University Hospital, Rennes, France; Institut Pasteur, Centre National de Re\u0301fe\u0301rence des Arbovirus, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Minjolle","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, Rennes, France; Virology, Pontchaillou University Hospital, Rennes, France; Pharmacovigilance, Pontchaillou University Hospital, Rennes, France; Institut Pasteur, Centre National de Re\u0301fe\u0301rence des Arbovirus, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Polard","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, Rennes, France; Virology, Pontchaillou University Hospital, Rennes, France; Pharmacovigilance, Pontchaillou University Hospital, Rennes, France; Institut Pasteur, Centre National de Re\u0301fe\u0301rence des Arbovirus, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabien","family":"Fily","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, Rennes, France; Virology, Pontchaillou University Hospital, Rennes, France; Pharmacovigilance, Pontchaillou University Hospital, Rennes, France; Institut Pasteur, Centre National de Re\u0301fe\u0301rence des Arbovirus, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herve\u0301","family":"Zeller","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, Rennes, France; Virology, Pontchaillou University Hospital, Rennes, France; Pharmacovigilance, Pontchaillou University Hospital, Rennes, France; Institut Pasteur, Centre National de Re\u0301fe\u0301rence des Arbovirus, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Michelet","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, Rennes, France; Virology, Pontchaillou University Hospital, Rennes, France; Pharmacovigilance, Pontchaillou University Hospital, Rennes, France; Institut Pasteur, Centre National de Re\u0301fe\u0301rence des Arbovirus, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Tattevin","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, Rennes, France; Virology, Pontchaillou University Hospital, Rennes, France; Pharmacovigilance, Pontchaillou University Hospital, Rennes, France; Institut Pasteur, Centre National de Re\u0301fe\u0301rence des Arbovirus, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Lancet Infect Dis","first-page":"11","volume":"1","year":"2001"},{"key":"R2","series-title":"Clin Infect Dis","first-page":"1369","volume":"34","year":"2002"},{"key":"R3","series-title":"Am J Trop Med Hyg","first-page":"644","volume":"59","year":"1998"},{"key":"R4","series-title":"Clin Infect Dis","first-page":"850","volume":"44","year":"2007"},{"key":"R5","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"643","volume":"50","year":"2001"},{"key":"R6","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"989","volume":"51","year":"2002"},{"key":"R7","series-title":"JAMA","first-page":"2533","volume":"288","year":"2002"},{"key":"R8","series-title":"Lancet","first-page":"121","volume":"358","year":"2001"},{"key":"R9","series-title":"Lancet","first-page":"98","volume":"358","year":"2001"},{"key":"R10","series-title":"Lancet","first-page":"91","volume":"358","year":"2001"},{"key":"R11","series-title":"Vaccine","first-page":"6077","volume":"26","year":"2008"},{"key":"R12","series-title":"Vaccine","first-page":"1727","volume":"25","year":"2007"},{"key":"R13","series-title":"J Infect Dis","first-page":"512","volume":"169","year":"1994"},{"key":"R14","series-title":"Vaccine","first-page":"3124","volume":"25","year":"2007"},{"key":"R15","series-title":"Vaccine","first-page":"3256","volume":"23","year":"2005"},{"key":"R16","series-title":"Vaccine","first-page":"2103","volume":"22","year":"2004"},{"key":"R17","series-title":"Trans R Soc Trop Med Hyg","first-page":"169","volume":"101","year":"2007"},{"key":"R18","series-title":"MMWR Recomm Rep","first-page":"1","volume":"51","year":"2002"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/81\/6\/article-p1141.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/81\/6\/article-p1141.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/81\/6\/article-p1141.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T14:52:16Z","timestamp":1725288736000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/81\/6\/article-p1141.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":18,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.2009.09-0295","relation":{},"ISSN":["0002-9637"],"issn-type":[{"value":"0002-9637","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}