{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:50:52Z","timestamp":1793235052814,"version":"4.5.0"},"reference-count":32,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Trop Med Hyg"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>This multi-center, randomized, parallel-group, double-blind, double-dummy study compared the efficacy and safety of chlorproguanil\u2013dapsone\u2013artesunate (CDA) and chlorproguanil\u2013dapsone (CPG\u2013DDS) in the treatment of falciparum malaria in Africa (Burkina Faso, Ghana, Mali, Nigeria). Six hundred patients (\u2265 1 year of age) received CDA 2.0\/2.5\/4.0 mg\/kg, and 292 CPG\u2013DDS 2.0\/2.5 mg\/kg, once daily for 3 days. Day 28 parasitologic cure rate (polymerase chain reaction [PCR]-corrected, per-protocol population) was 89.1% (416\/467) for CDA, non-inferior but also superior to CPG\u2013DDS, 83.0% (176\/212) (treatment difference 6.1%; 95% confidence interval [CI] 0.3, 11.9). Glucose-6-phosphate dehydrogenase (G6PD) genotype was available for 844\/892 (95%) patients. Occurrences of a composite hemoglobin safety endpoint (hemoglobin drop \u2265 40 g\/L or \u2265 40% versus baseline, hemoglobin &lt; 50 g\/L, or blood transfusion) were CDA 13\/44 (30%), CPG\u2013DDS 7\/24 (29%) in G6PD-deficient patients versus CDA 4\/448 (&lt; 1%), CPG\u2013DDS 6\/221 (3%) in G6PD-normal patients. No deaths occurred. CDA was more efficacious than CPG\u2013DDS. However, the hemolytic potential in G6PD-deficient patients does not support further development of CDA.<\/jats:p>","DOI":"10.4269\/ajtmh.2009.09-0351","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T22:29:10Z","timestamp":1260311350000},"page":"969-978","source":"Crossref","is-referenced-by-count":31,"title":["Chlorproguanil\u2013Dapsone\u2013Artesunate versus Chlorproguanil\u2013Dapsone: A Randomized, Double-Blind, Phase III Trial in African Children, Adolescents, and Adults with Uncomplicated Plasmodium falciparum Malaria"],"prefix":"10.4269","volume":"81","author":[{"given":"Alfred B.","family":"Tiono","sequence":"first","affiliation":[{"name":"Centre National de Recherche et de Formation sur le Paludisme, Ministe\u0300re de la Sante\u0301, Ouagadougou, Burkina Faso; Malaria Research and Training Centre and Department of Public Health, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali; Obafemi Awolowo University Teaching Hospital, Department of Medicine, Ile Ife, Nigeria; Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Medicine, Plateau State Specialist Hospital, Jos, Plateau State..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alassane","family":"Dicko","sequence":"additional","affiliation":[{"name":"Centre National de Recherche et de Formation sur le Paludisme, Ministe\u0300re de la Sante\u0301, Ouagadougou, Burkina Faso; Malaria Research and Training Centre and Department of Public Health, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali; Obafemi Awolowo University Teaching Hospital, Department of Medicine, Ile Ife, Nigeria; Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Medicine, Plateau State Specialist Hospital, Jos, Plateau State..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis A.","family":"Ndububa","sequence":"additional","affiliation":[{"name":"Centre National de Recherche et de Formation sur le Paludisme, Ministe\u0300re de la Sante\u0301, Ouagadougou, Burkina Faso; Malaria Research and Training Centre and Department of Public Health, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali; Obafemi Awolowo University Teaching Hospital, Department of Medicine, Ile Ife, Nigeria; Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Medicine, Plateau State Specialist Hospital, Jos, Plateau State..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsiri","family":"Agbenyega","sequence":"additional","affiliation":[{"name":"Centre National de Recherche et de Formation sur le Paludisme, Ministe\u0300re de la Sante\u0301, Ouagadougou, Burkina Faso; Malaria Research and Training Centre and Department of Public Health, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali; Obafemi Awolowo University Teaching Hospital, Department of Medicine, Ile Ife, Nigeria; Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Medicine, Plateau State Specialist Hospital, Jos, Plateau State..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Pitmang","sequence":"additional","affiliation":[{"name":"Centre National de Recherche et de Formation sur le Paludisme, Ministe\u0300re de la Sante\u0301, Ouagadougou, Burkina Faso; Malaria Research and Training Centre and Department of Public Health, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali; Obafemi Awolowo University Teaching Hospital, Department of Medicine, Ile Ife, Nigeria; Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Medicine, Plateau State Specialist Hospital, Jos, Plateau State..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Awobusuyi","sequence":"additional","affiliation":[{"name":"Centre National de Recherche et de Formation sur le Paludisme, Ministe\u0300re de la Sante\u0301, Ouagadougou, Burkina Faso; Malaria Research and Training Centre and Department of Public Health, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali; Obafemi Awolowo University Teaching Hospital, Department of Medicine, Ile Ife, Nigeria; Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Medicine, Plateau State Specialist Hospital, Jos, Plateau State..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Pamba","sequence":"additional","affiliation":[{"name":"Centre National de Recherche et de Formation sur le Paludisme, Ministe\u0300re de la Sante\u0301, Ouagadougou, Burkina Faso; Malaria Research and Training Centre and Department of Public Health, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali; Obafemi Awolowo University Teaching Hospital, Department of Medicine, Ile Ife, Nigeria; Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Medicine, Plateau State Specialist Hospital, Jos, Plateau State..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Duparc","sequence":"additional","affiliation":[{"name":"Centre National de Recherche et de Formation sur le Paludisme, Ministe\u0300re de la Sante\u0301, Ouagadougou, Burkina Faso; Malaria Research and Training Centre and Department of Public Health, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali; Obafemi Awolowo University Teaching Hospital, Department of Medicine, Ile Ife, Nigeria; Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Medicine, Plateau State Specialist Hospital, Jos, Plateau State..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ean","family":"Goh","sequence":"additional","affiliation":[{"name":"Centre National de Recherche et de Formation sur le Paludisme, Ministe\u0300re de la Sante\u0301, Ouagadougou, Burkina Faso; Malaria Research and Training Centre and Department of Public Health, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali; Obafemi Awolowo University Teaching Hospital, Department of Medicine, Ile Ife, Nigeria; Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Medicine, Plateau State Specialist Hospital, Jos, Plateau State..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Harrell","sequence":"additional","affiliation":[{"name":"Centre National de Recherche et de Formation sur le Paludisme, Ministe\u0300re de la Sante\u0301, Ouagadougou, Burkina Faso; Malaria Research and Training Centre and Department of Public Health, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali; Obafemi Awolowo University Teaching Hospital, Department of Medicine, Ile Ife, Nigeria; Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Medicine, Plateau State Specialist Hospital, Jos, Plateau State..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Carter","sequence":"additional","affiliation":[{"name":"Centre National de Recherche et de Formation sur le Paludisme, Ministe\u0300re de la Sante\u0301, Ouagadougou, Burkina Faso; 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