{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:55:30Z","timestamp":1793476530568,"version":"4.5.0"},"reference-count":52,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Trop Med Hyg"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>The main risk factor of post-ivermectin serious adverse events (SAEs) is the presence of a high <jats:italic>Loa loa<\/jats:italic> microfilaremia. However, the majority of patients with such high loads do not develop SAEs, suggesting that co-factors may be involved. An infection with simian <jats:italic>Loa<\/jats:italic> parasites, whose microfilariae show a nocturnal periodicity, might be such a co-factor. The periodicity of <jats:italic>Loa<\/jats:italic> microfilariae was compared, using cosinor methodology, in 4 patients who had developed a post-ivermectin neurologic SAE, 4 patients who had experienced a non-neurologic SAE, and 14 control individuals. The periodicity was similar in all three groups, with a peak of microfilaremia occurring between 12:30 and 2:00 <jats:sc>pm<\/jats:sc>. The results of this study, which for the first time characterizes the periodicity of <jats:italic>Loa<\/jats:italic> microfilariae mathematically, suggest that post-ivermectin SAEs are not related to an infection with a <jats:italic>Loa<\/jats:italic> simian strain.<\/jats:p>","DOI":"10.4269\/ajtmh.2009.09-0356","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T22:29:10Z","timestamp":1260311350000},"page":"1056-1061","source":"Crossref","is-referenced-by-count":29,"title":["Loa loa Microfilarial Periodicity in Ivermectin-Treated Patients: Comparison Between Those Developing and Those Free of Serious Adverse Events"],"prefix":"10.4269","volume":"81","author":[{"given":"Joseph","family":"Kamgno","sequence":"first","affiliation":[{"name":"Filariasis Research Centre and Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon; Unite\u0301 Mixte de Recherche 145, Institut de Recherche pour le De\u0301veloppement and Universite\u0301 Montpellier 1, Montpellier, France; Filarial Diseases Unit, Michigan State University, East Lansing, Michigan; Mectizan Donation Program, Decatur, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se\u0301bastien D.","family":"Pion","sequence":"additional","affiliation":[{"name":"Filariasis Research Centre and Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon; Unite\u0301 Mixte de Recherche 145, Institut de Recherche pour le De\u0301veloppement and Universite\u0301 Montpellier 1, Montpellier, France; Filarial Diseases Unit, Michigan State University, East Lansing, Michigan; Mectizan Donation Program, Decatur, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles D.","family":"Mackenzie","sequence":"additional","affiliation":[{"name":"Filariasis Research Centre and Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon; Unite\u0301 Mixte de Recherche 145, Institut de Recherche pour le De\u0301veloppement and Universite\u0301 Montpellier 1, Montpellier, France; Filarial Diseases Unit, Michigan State University, East Lansing, Michigan; Mectizan Donation Program, Decatur, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjo\u0308rn","family":"Thylefors","sequence":"additional","affiliation":[{"name":"Filariasis Research Centre and Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon; Unite\u0301 Mixte de Recherche 145, Institut de Recherche pour le De\u0301veloppement and Universite\u0301 Montpellier 1, Montpellier, France; Filarial Diseases Unit, Michigan State University, East Lansing, Michigan; Mectizan Donation Program, Decatur, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Boussinesq","sequence":"additional","affiliation":[{"name":"Filariasis Research Centre and Faculty of Medicine and Biomedical Sciences, University of Yaounde 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