{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:11:41Z","timestamp":1761988301198},"reference-count":46,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p>The merozoite surface protein 1 (MSP1) is the principal surface antigen of the blood stage form of the <jats:italic>Plasmodium<\/jats:italic> parasite. Antibodies recognizing MSP1 are frequently detected following <jats:italic>Plasmodium<\/jats:italic> infection, making this protein a significant component of malaria vaccines and diagnostic tests. Although the MSP1 gene sequence has been reported for <jats:italic>Plasmodium falciparum<\/jats:italic> and <jats:italic>Plasmodium vivax<\/jats:italic>, this gene has not been identified for the other two major human-infectious species, <jats:italic>Plasmodium malariae<\/jats:italic> and <jats:italic>Plasmodium ovale<\/jats:italic>. MSP1 genes from these two species were isolated from Cameroon blood donor samples. The genes are similar in size to known MSP1 genes and encode proteins with interspecies conserved domains homologous to those identified in other <jats:italic>Plasmodium<\/jats:italic> species. Sequence and phylogenetic analysis of all available <jats:italic>Plasmodium<\/jats:italic> MSP1 amino acid sequences clearly shows that the <jats:italic>Po<\/jats:italic> and <jats:italic>Pm<\/jats:italic> MSP1 sequences are truly unique within the <jats:italic>Plasmodium<\/jats:italic> genus and not simply <jats:italic>Pf<\/jats:italic> or <jats:italic>Pv<\/jats:italic> variants.<\/jats:p>","DOI":"10.4269\/ajtmh.2010.09-0022","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T19:04:52Z","timestamp":1275505492000},"page":"996-1003","source":"Crossref","is-referenced-by-count":22,"title":["Isolation and Characterization of the MSP1 Genes from Plasmodium malariae and Plasmodium ovale"],"prefix":"10.4269","volume":"82","author":[{"given":"Larry","family":"Birkenmeyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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ovale\u2013the \u201cbashful\u201d malaria parasites","volume":"23","author":"Mueller","year":"2007"},{"key":"R5","series-title":"Clin Infect Dis","first-page":"165","article-title":"Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening","volume":"46","author":"Cox-Singh","year":"2008"},{"key":"R6","series-title":"Clin Infect Dis","first-page":"172","article-title":"Plasmodium knowlesi: the fifth human malaria parasite","volume":"46","author":"White","year":"2008"},{"key":"R7","series-title":"Nature","first-page":"520","article-title":"A proteomic view of the Plasmodium falciparum life cycle","volume":"419","author":"Florens","year":"2002"},{"key":"R8","series-title":"Parasitology","first-page":"11","article-title":"Monkeys of the rainforest in French Guiana are natural reservoirs for P. brasilianum\/P. malariae malaria","volume":"120","author":"Fandeur","year":"2000"},{"key":"R9","series-title":"Mol Biochem Parasitol","first-page":"131","article-title":"Structural analysis of the glycosyl-phosphatidylinositol membrane anchor of the merozoite surface proteins-1 and -2 of Plasmodium falciparum","volume":"75","author":"Gerold","year":"1996"},{"key":"R10","series-title":"Curr Drug Targets","first-page":"59","article-title":"Proteases involved in erythrocyte invasion by the malaria parasite: function and potential as chemotherapeutic targets","volume":"1","author":"Blackman","year":"2000"},{"key":"R11","series-title":"Mol Biochem Parasitol","first-page":"35","article-title":"Processing of the Plasmodium falciparum major merozoite surface protein-1: identification of a 33-kilodalton secondary processing product which is shed prior to erythrocyte invasion","volume":"49","author":"Blackman","year":"1991"},{"key":"R12","series-title":"Mol Biochem Parasitol","first-page":"111","article-title":"Processing of the Plasmodium chabaudi chabaudi AS merozoite surface protein 1 in vivo and in vitro","volume":"72","author":"O'Dea","year":"1995"},{"key":"R13","series-title":"Exp Parasitol","first-page":"229","article-title":"Plasmodium knowlesi: secondary processing of the malaria merozoite surface protein-1","volume":"83","author":"Blackman","year":"1996"},{"key":"R14","series-title":"Infect Immun","first-page":"40","article-title":"A prospective study of the association between the human humoral immune response to Plasmodium falciparum blood stage antigen gp190 and control of malarial infections","volume":"61","author":"Tolle","year":"1993"},{"key":"R15","series-title":"Infect Immun","first-page":"456","article-title":"Serum antibodies from malaria-exposed people recognize conserved epitopes formed by the two epidermal growth factor motifs of MSP1(19), the carboxy-terminal fragment of the major merozoite surface protein of Plasmodium falciparum","volume":"63","author":"Egan","year":"1995"},{"key":"R16","series-title":"Infect Immun","first-page":"5947","article-title":"Malaria vaccine-related benefits of a single protein comprising Plasmodium falciparum apical membrane antigen 1 domains I and II fused to a modified form of the 19-kilodalton C-terminal fragment of merozoite surface protein 1","volume":"75","author":"Faber","year":"2007"},{"key":"R17","series-title":"Infect Immun","first-page":"1536","article-title":"Efficacy of two alternate vaccines based on Plasmodium falciparum merozoite surface protein 1 in an Aotus challenge trial","volume":"69","author":"Stowers","year":"2001"},{"key":"R18","series-title":"Korean J Parasitol","first-page":"203","article-title":"ELISA detection of vivax malaria with recombinant multiple stage-specific antigens and its application to survey of residents in endemic areas","volume":"41","author":"Kim","year":"2003"},{"key":"R19","series-title":"Vox Sang","first-page":"150","article-title":"Evaluation of a malarial antibody assay for use in the screening of blood and tissue products for clinical use","volume":"87","author":"Kitchen","year":"2004"},{"key":"R20","series-title":"Am J Trop Med Hyg","first-page":"229","article-title":"Malaria in pregnant Cameroonian women: the effect of age and gravidity on submicroscopic and mixed-species infections and multiple parasite genotypes","volume":"72","author":"Walker-Abbey","year":"2005"},{"key":"R21","series-title":"J Clin Microbiol","first-page":"2435","article-title":"Real-time PCR for detection and identification of Plasmodium spp","volume":"43","author":"Mangold","year":"2005"},{"key":"R22","series-title":"Nucleic Acids Res","first-page":"3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997"},{"year":"2001","series-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook","key":"R23"},{"year":"2005","series-title":"Wisconsin Package Version 11.0","author":"Genetics Computer Group","key":"R24"},{"key":"R25","series-title":"Mol Biol Evol","first-page":"1596","article-title":"MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0","volume":"24","author":"Tamura","year":"2007"},{"key":"R26","series-title":"Mol Biol Evol","first-page":"418","article-title":"Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions","volume":"3","author":"Nei","year":"1986"},{"key":"R27","series-title":"J Mol Biol","first-page":"741","article-title":"Prediction of potential GPI-modification sites in proprotein sequences","volume":"292","author":"Eisenhaber","year":"1999"},{"key":"R28","series-title":"J Mol Biol","first-page":"783","article-title":"Improved prediction of signal peptides: SignalP 3.0","volume":"340","author":"Bendtsen","year":"2004"},{"key":"R29","series-title":"Comput Appl Biosci","first-page":"275","article-title":"The rapid generation of mutation data matrices from protein sequences","volume":"8","author":"Jones","year":"1992"},{"key":"R30","series-title":"Evolution","first-page":"783","article-title":"Confidence limits on phylogenies: an approach using the bootstrap","volume":"39","author":"Felsenstein","year":"1985"},{"key":"R31","series-title":"Emerg Infect Dis","first-page":"1235","article-title":"Molecular analysis of Plasmodium ovale variants","volume":"10","author":"Win","year":"2004"},{"key":"R32","series-title":"Mol Biochem Parasitol","first-page":"74","article-title":"Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites","volume":"156","author":"Tanabe","year":"2007"},{"key":"R33","series-title":"Mol Biochem Parasitol","first-page":"29","article-title":"Proteolytic processing of the Plasmodium falciparum merozoite surface protein-1 produces a membrane-bound fragment containing two epidermal growth factor-like domains","volume":"49","author":"Blackman","year":"1991"},{"key":"R34","series-title":"Mol Biochem Parasitol","first-page":"231","article-title":"Molecular cloning and sequence analysis of the gene encoding the major merozoite surface antigen of Plasmodium chabaudi chabaudi IP-PC1","volume":"43","author":"Deleersnijder","year":"1990"},{"key":"R35","series-title":"Am J Trop Med Hyg","first-page":"994","article-title":"Cloning and characterization of the merozoite surface antigen 1 gene of Plasmodium berghei","volume":"60","author":"Zhong","year":"1999"},{"key":"R36","series-title":"EMBO J","first-page":"725","article-title":"A multifunctional serine protease primes the malaria parasite for red blood cell invasion","volume":"28","author":"Koussis","year":"2009"},{"key":"R37","series-title":"Mol Microbiol","first-page":"55","article-title":"Subtilisin-like proteases of the malaria parasite","volume":"53","author":"Withers-Martinez","year":"2004"},{"key":"R38","series-title":"PLoS Pathog","first-page":"241","article-title":"Molecular identification of a malaria merozoite surface sheddase","volume":"1","author":"Harris","year":"2005"},{"key":"R39","series-title":"J Exp Med","first-page":"1563","article-title":"Glycosylphosphatidylinositol anchors of Plasmodium falciparum: molecular characterization and naturally elicited antibody response that may provide immunity to malaria pathogenesis","volume":"192","author":"Naik","year":"2000"},{"key":"R40","series-title":"Annu Rev Biochem","first-page":"563","article-title":"How glycosylphosphatidylinositol-anchored membrane proteins are made","volume":"64","author":"Udenfriend","year":"1995"},{"key":"R41","series-title":"Mol Biol Evol","first-page":"381","article-title":"Positive selection and interallelic recombination at the merozoite surface antigen-1 (MSA-1) locus of Plasmodium falciparum","volume":"9","author":"Hughes","year":"1992"},{"key":"R42","series-title":"Parasitology","first-page":"677","article-title":"Evolutionary relationships between 15 Plasmodium species from new and old world primates (including humans): an 18S rDNA cladistic analysis","volume":"129","author":"Leclerc","year":"2004"},{"key":"R43","series-title":"PLoS Pathog","first-page":"e1000446","article-title":"A new malaria agent in African hominids","volume":"5","author":"Ollomo","year":"2009"},{"key":"R44","series-title":"J Parasitol","first-page":"972","article-title":"A molecular phylogeny of malarial parasites recovered from cytochrome b gene sequences","volume":"88","author":"Perkins","year":"2002"},{"key":"R45","series-title":"Proc Natl Acad Sci USA","first-page":"14902","article-title":"The origin of malignant malaria","volume":"106","author":"Rich","year":"2009"},{"key":"R46","series-title":"J Mol Evol","first-page":"565","article-title":"An updated and comprehensive rRNA 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