{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:45:53Z","timestamp":1791585953125,"version":"4.3.4"},"reference-count":33,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2]]},"abstract":"We reported previously that Cryptosporidium parvum<\/jats:italic> was able to induce intestinal tumors in severe combined immunodeficiency (SCID) mice treated with corticoids. To further characterize this Cryptosporidium<\/jats:italic>-induced cell transformation, SCID mice treated with dexamethasone were challenged with C. parvum<\/jats:italic> oocysts, and euthanatized sequentially after infection for histologic examination. Ki-67 was used as a marker of cellular proliferation. Our previous results were confirmed, and it was also found that mice receiving higher inocula (106<\/jats:sup>\u2013107<\/jats:sup>) experienced more severe neoplastic development. Additionally, neoplastic changes were observed not only in the caecum but also in the stomach and duodenum of some animals. Interestingly, SCID mice (6\/6) inoculated with 105<\/jats:sup>\u2013107<\/jats:sup> oocysts showed high grade intraepithelial neoplasia or adenomas with high grade dysplasia in the caecum after Day 46 post-infection (PI). Immunohistochemistry for Ki-67 staining indicated the neoplastic process associated to cryptosporidiosis, and evidenced the first immunohistochemical alterations at early stages of the process, even at 3 weeks PI.<\/jats:p>","DOI":"10.4269\/ajtmh.2010.09-0309","type":"journal-article","created":{"date-parts":[[2010,2,5]],"date-time":"2010-02-05T01:22:23Z","timestamp":1265332943000},"page":"257-265","source":"Crossref","is-referenced-by-count":37,"title":["Development of Cryptosporidium parvum-Induced Gastrointestinal Neoplasia in Severe Combined Immunodeficiency (SCID) Mice: Severity of Lesions Is Correlated with Infection Intensity"],"prefix":"10.4269","volume":"82","author":[{"given":"Gabriela","family":"Certad","sequence":"first","affiliation":[{"name":"Ecologie du Parasitisme (EA3609 Universit\u00e9 de Lille 2), IFR 142, Institut Pasteur de Lille, Lille, France; C\u00e1tedra de Parasitolog\u00eda, Escuela de Medicina \u201cJos\u00e9 Mar\u00eda Vargas,\u201d Universidad Central de Venezuela (UCV), Caracas, Venezuela; Service d\u2019Anatomie et de Cytologie Pathologiques, Groupe Hospitalier de l\u2019Universit\u00e9 Catholique de Lille, Lille, France; Plateau d\u2019Exp\u00e9rimentation Animale, Institut Pasteur de Lille, France; Unit\u00e9 de S\u00e9curit\u00e9 Microbiologique, Institut Pasteur de Lille, Lille..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colette","family":"Creusy","sequence":"additional","affiliation":[{"name":"Ecologie du Parasitisme (EA3609 Universit\u00e9 de Lille 2), IFR 142, Institut Pasteur de Lille, Lille, France; C\u00e1tedra de Parasitolog\u00eda, Escuela de Medicina \u201cJos\u00e9 Mar\u00eda Vargas,\u201d Universidad Central de Venezuela (UCV), Caracas, Venezuela; Service d\u2019Anatomie et de Cytologie Pathologiques, Groupe Hospitalier de l\u2019Universit\u00e9 Catholique de Lille, Lille, France; Plateau d\u2019Exp\u00e9rimentation Animale, Institut Pasteur de Lille, France; Unit\u00e9 de S\u00e9curit\u00e9 Microbiologique, Institut Pasteur de Lille, Lille..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tramy","family":"Ngouanesavanh","sequence":"additional","affiliation":[{"name":"Ecologie du Parasitisme (EA3609 Universit\u00e9 de Lille 2), IFR 142, Institut Pasteur de Lille, Lille, France; C\u00e1tedra de Parasitolog\u00eda, Escuela de Medicina \u201cJos\u00e9 Mar\u00eda Vargas,\u201d Universidad Central de Venezuela (UCV), Caracas, Venezuela; Service d\u2019Anatomie et de Cytologie Pathologiques, Groupe Hospitalier de l\u2019Universit\u00e9 Catholique de Lille, Lille, France; Plateau d\u2019Exp\u00e9rimentation Animale, Institut Pasteur de Lille, France; Unit\u00e9 de S\u00e9curit\u00e9 Microbiologique, Institut Pasteur de Lille, Lille..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Guyot","sequence":"additional","affiliation":[{"name":"Ecologie du Parasitisme (EA3609 Universit\u00e9 de Lille 2), IFR 142, Institut Pasteur de Lille, Lille, France; C\u00e1tedra de Parasitolog\u00eda, Escuela de Medicina \u201cJos\u00e9 Mar\u00eda Vargas,\u201d Universidad Central de Venezuela (UCV), Caracas, Venezuela; Service d\u2019Anatomie et de Cytologie Pathologiques, Groupe Hospitalier de l\u2019Universit\u00e9 Catholique de Lille, Lille, France; Plateau d\u2019Exp\u00e9rimentation Animale, Institut Pasteur de Lille, France; Unit\u00e9 de S\u00e9curit\u00e9 Microbiologique, Institut Pasteur de Lille, Lille..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nausicaa","family":"Gantois","sequence":"additional","affiliation":[{"name":"Ecologie du Parasitisme (EA3609 Universit\u00e9 de Lille 2), IFR 142, Institut Pasteur de Lille, Lille, France; C\u00e1tedra de Parasitolog\u00eda, Escuela de Medicina \u201cJos\u00e9 Mar\u00eda Vargas,\u201d Universidad Central de Venezuela (UCV), Caracas, Venezuela; Service d\u2019Anatomie et de Cytologie Pathologiques, Groupe Hospitalier de l\u2019Universit\u00e9 Catholique de Lille, Lille, France; Plateau d\u2019Exp\u00e9rimentation Animale, Institut Pasteur de Lille, France; Unit\u00e9 de S\u00e9curit\u00e9 Microbiologique, Institut Pasteur de Lille, Lille..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Mouray","sequence":"additional","affiliation":[{"name":"Ecologie du Parasitisme (EA3609 Universit\u00e9 de Lille 2), IFR 142, Institut Pasteur de Lille, Lille, France; C\u00e1tedra de Parasitolog\u00eda, Escuela de Medicina \u201cJos\u00e9 Mar\u00eda Vargas,\u201d Universidad Central de Venezuela (UCV), Caracas, Venezuela; Service d\u2019Anatomie et de Cytologie Pathologiques, Groupe Hospitalier de l\u2019Universit\u00e9 Catholique de Lille, Lille, France; Plateau d\u2019Exp\u00e9rimentation Animale, Institut Pasteur de Lille, France; Unit\u00e9 de S\u00e9curit\u00e9 Microbiologique, Institut Pasteur de Lille, Lille..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Chassat","sequence":"additional","affiliation":[{"name":"Ecologie du Parasitisme (EA3609 Universit\u00e9 de Lille 2), IFR 142, Institut Pasteur de Lille, Lille, France; C\u00e1tedra de Parasitolog\u00eda, Escuela de Medicina \u201cJos\u00e9 Mar\u00eda Vargas,\u201d Universidad Central de Venezuela (UCV), Caracas, Venezuela; Service d\u2019Anatomie et de Cytologie Pathologiques, Groupe Hospitalier de l\u2019Universit\u00e9 Catholique de Lille, Lille, France; Plateau d\u2019Exp\u00e9rimentation Animale, Institut Pasteur de Lille, France; Unit\u00e9 de S\u00e9curit\u00e9 Microbiologique, Institut Pasteur de Lille, Lille..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Flament","sequence":"additional","affiliation":[{"name":"Ecologie du Parasitisme (EA3609 Universit\u00e9 de Lille 2), IFR 142, Institut Pasteur de Lille, Lille, France; C\u00e1tedra de Parasitolog\u00eda, Escuela de Medicina \u201cJos\u00e9 Mar\u00eda Vargas,\u201d Universidad Central de Venezuela (UCV), Caracas, Venezuela; Service d\u2019Anatomie et de Cytologie Pathologiques, Groupe Hospitalier de l\u2019Universit\u00e9 Catholique de Lille, Lille, France; Plateau d\u2019Exp\u00e9rimentation Animale, Institut Pasteur de Lille, France; Unit\u00e9 de S\u00e9curit\u00e9 Microbiologique, Institut Pasteur de Lille, Lille..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Fleurisse","sequence":"additional","affiliation":[{"name":"Ecologie du Parasitisme (EA3609 Universit\u00e9 de Lille 2), IFR 142, Institut Pasteur de Lille, Lille, France; C\u00e1tedra de Parasitolog\u00eda, Escuela de Medicina \u201cJos\u00e9 Mar\u00eda Vargas,\u201d Universidad Central de Venezuela (UCV), Caracas, Venezuela; Service d\u2019Anatomie et de Cytologie Pathologiques, Groupe Hospitalier de l\u2019Universit\u00e9 Catholique de Lille, Lille, France; Plateau d\u2019Exp\u00e9rimentation Animale, Institut Pasteur de Lille, France; Unit\u00e9 de S\u00e9curit\u00e9 Microbiologique, Institut Pasteur de Lille, Lille..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Pinon","sequence":"additional","affiliation":[{"name":"Ecologie du Parasitisme (EA3609 Universit\u00e9 de Lille 2), IFR 142, Institut Pasteur de Lille, Lille, France; C\u00e1tedra de Parasitolog\u00eda, Escuela de Medicina \u201cJos\u00e9 Mar\u00eda Vargas,\u201d Universidad Central de Venezuela (UCV), Caracas, Venezuela; Service d\u2019Anatomie et de Cytologie Pathologiques, Groupe Hospitalier de l\u2019Universit\u00e9 Catholique de Lille, Lille, France; Plateau d\u2019Exp\u00e9rimentation Animale, Institut Pasteur de Lille, France; Unit\u00e9 de S\u00e9curit\u00e9 Microbiologique, Institut Pasteur de Lille, Lille..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Delhaes","sequence":"additional","affiliation":[{"name":"Ecologie du Parasitisme (EA3609 Universit\u00e9 de Lille 2), IFR 142, Institut Pasteur de Lille, Lille, France; C\u00e1tedra de Parasitolog\u00eda, Escuela de Medicina \u201cJos\u00e9 Mar\u00eda Vargas,\u201d Universidad Central de Venezuela (UCV), Caracas, Venezuela; Service d\u2019Anatomie et de Cytologie Pathologiques, Groupe Hospitalier de l\u2019Universit\u00e9 Catholique de Lille, Lille, France; Plateau d\u2019Exp\u00e9rimentation Animale, Institut Pasteur de Lille, France; Unit\u00e9 de S\u00e9curit\u00e9 Microbiologique, Institut Pasteur de Lille, Lille..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Dei-Cas","sequence":"additional","affiliation":[{"name":"Ecologie du Parasitisme (EA3609 Universit\u00e9 de Lille 2), IFR 142, Institut Pasteur de Lille, Lille, France; 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