{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T05:49:46Z","timestamp":1793684986005,"version":"4.5.1"},"reference-count":49,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>We have reported the epidemic patterns of dengue disease in the Region of the Americas from 1980 through 2007. Dengue cases reported to the Pan American Health Organization were analyzed from three periods: 1980\u20131989 (80s), 1990\u20131999 (90s), and 2000\u20132007 (2000\u20137). Age distribution data were examined from Brazil, Venezuela, Honduras, and Mexico. Cases increased over time: 1,033,417 (80s) to 2,725,405 (90s) to 4,759,007 (2000\u20137). The highest concentrations were reported in the Hispanic Caribbean (39.1%) in the 80s shifting to the Southern Cone in the 90s (55%) and 2000\u20137 (62.9%). From 1980 through 1987, 242 deaths were reported compared with 1,391 during 2000\u20137. The most frequently isolated serotypes were DENV-1 and DENV-2 (90s) and DENV-2 and DENV-3 (2000\u20137). The highest incidence was observed among adolescents and young adults; dengue hemorrhagic fever incidence was highest among infants in Venezuela. Increasing dengue morbidity\/mortality was observed in the Americas in recent decades.<\/jats:p>","DOI":"10.4269\/ajtmh.2010.09-0346","type":"journal-article","created":{"date-parts":[[2010,1,11]],"date-time":"2010-01-11T16:47:50Z","timestamp":1263228470000},"page":"128-135","source":"Crossref","is-referenced-by-count":368,"title":["The Epidemiology of Dengue in the Americas Over the Last Three Decades: A Worrisome Reality"],"prefix":"10.4269","volume":"82","author":[{"given":"Jos\u00e9 Luis","family":"San Mart\u00edn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Brathwaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betzana","family":"Zambrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Orlando","family":"Sol\u00f3rzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Bouckenooghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo H.","family":"Dayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda G.","family":"Guzm\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Dengue and Dengue Hemorrhagic Fever","first-page":"175","author":"Chang","year":"1997"},{"key":"R2","series-title":"Dengue and Dengue Hemorrhagic Fever","first-page":"133","author":"Nimmannitya","year":"1997M"},{"key":"R3","series-title":"Dengue and dengue hemorrhagic fever: diagnosis, treatment, prevention and control","first-page":"1","author":"World Health Organization","year":"1997"},{"key":"R4","series-title":"Strengthening Implementation of the Global Strategy for Dengue Fever and Dengue Hemorrhagic Fever, Prevention and Control","author":"World Health Organization","year":"1999"},{"key":"R5","series-title":"Rev Panam Salud Publica","first-page":"204","article-title":"Dengue and dengue hemorrhagic fever: research priorities","volume":"19","author":"Guzm\u00e1n","year":"2006"},{"key":"R6","series-title":"Rev Panam Salud Publica","first-page":"187","article-title":"Dengue and hemorrhagic dengue in the Americas","volume":"21","author":"Periago","year":"2007"},{"key":"R7","series-title":"Number of reported cases of dengue and dengue hemorrhagic fever (DHF), Region of the Americas (by country and subregion) from 1995 through 2007","author":"Pan American Health Organization (PAHO)","year":"2007"},{"key":"R8","series-title":"Dengue and Dengue Hemorrhagic Fever in the Americas: Guidelines for Prevention and Control","author":"Pan American Health Organization","year":"1994"},{"key":"R9","series-title":"Department of Commerce, International Database","author":"US Census Bureau"},{"key":"R10","series-title":"Dengue: Notifica\u00e7\u00f5es registradas no Sistema de Informa\u00e7\u00e3o de Agravos de Notifica\u00e7\u00e3o \u2013 SINAN, Brazil","author":"Minist\u00e9rio da Sa\u00fade"},{"key":"R11","series-title":"SINAN. 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