{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:17:33Z","timestamp":1790543853907,"version":"4.1.0"},"reference-count":33,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,5]]},"abstract":"<jats:p>Microscopic examination of placental tissue can provide an accurate assessment of malaria infection during pregnancy. In this cross-sectional study of 193 women in Iquitos, Peru, 1.0% and 6.6% had parasites in the peripheral blood as detected by microscopy and polymerase chain reaction, respectively. However, 22% had placental malaria pigment indicating past, subclinical infections. Placental tissues with pigment from 24 cases were matched by gravidity and month of delivery to 24 controls and histopathologically examined. Cases had significantly higher number of monocytes in the intervillous space (44.7 versus 25.5; <jats:italic>P<\/jats:italic> = 0.012). Pigmented monocytes in fetal vessels were present in 33.3% of cases. This study demonstrated that subclinical malarial infection occurred frequently in pregnant women and is associated with increased presence of monocytes in the placenta. Pigmented monocytes in fetal vessels suggest parasites can breach the placental barrier and enter the fetal circulation.<\/jats:p>","DOI":"10.4269\/ajtmh.2010.09-0445","type":"journal-article","created":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T11:28:05Z","timestamp":1288351685000},"page":"973-980","source":"Crossref","is-referenced-by-count":32,"title":["Placental Histopathologic Changes Associated with Subclinical Malaria Infection and Its Impact on the Fetal Environment"],"prefix":"10.4269","volume":"83","author":[{"given":"Falgunee K.","family":"Parekh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billie B.","family":"Davison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionicia","family":"Gamboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OraLee H.","family":"Branch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Malar J","first-page":"126","article-title":"Diagnostic comparison of malaria infection in peripheral blood, placental blood and placental biopsies in Cameroonian parturient women","volume":"8","author":"Anchang-Kimbi","year":"2009"},{"key":"R2","series-title":"J Clin Microbiol","first-page":"1370","article-title":"Diagnosis of Plasmodium falciparum malaria at delivery: comparison of blood film preparation methods and of blood films with histology","volume":"41","author":"Rogerson","year":"2003"},{"key":"R3","series-title":"Am J Trop Med Hyg","first-page":"398","article-title":"The effects of Plasmodium falciparum and P. vivax infections on placental histopathology in an area of low malaria transmission","volume":"70","author":"McGready","year":"2004"},{"key":"R4","series-title":"Ann Trop Med Parasitol","first-page":"803","article-title":"The placenta and malaria","volume":"91","author":"Matteelli","year":"1997"},{"key":"R5","series-title":"Histopathology","first-page":"211","article-title":"Placental malaria. 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