{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:43:05Z","timestamp":1771659785712,"version":"3.50.1"},"reference-count":66,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p>Onchocerciasis control is currently based on mass ivermectin treatment. Unfortunately, this drug can induce serious adverse events (SAEs) in persons with high levels of <jats:italic>Loa loa<\/jats:italic> microfilaremia (&gt; 30,000 microfilaria\/mL). A means of preventing SAEs would be to treat at risk populations with a drug that would progressively reduce the microfilarial loads before administering ivermectin. Antimalarial drugs are a potential solution because they have shown some activity against various filarial species. A controlled trial was conducted to assess the effect of standard doses of quinine, chloroquine, amodiaquine, and artesunate on <jats:italic>L. loa<\/jats:italic> microfilaremia. Ninety-eight patients were randomly allocated into five groups (one for each drug and a control group) after stratification on microfilarial load. <jats:italic>Loa loa<\/jats:italic> microfilaremia was monitored on days 0, 3, 7, 15, 30, 60, and 90. No significant change in the loads was recorded in any of the treatment groups. A comprehensive review of the effects of antimalarial drugs against filariae is also provided.<\/jats:p>","DOI":"10.4269\/ajtmh.2010.09-0573","type":"journal-article","created":{"date-parts":[[2010,3,5]],"date-time":"2010-03-05T18:59:46Z","timestamp":1267815586000},"page":"379-385","source":"Crossref","is-referenced-by-count":14,"title":["A Controlled Trial to Assess the Effect of Quinine, Chloroquine, Amodiaquine, and Artesunate on Loa loa Microfilaremia"],"prefix":"10.4269","volume":"82","author":[{"given":"Joseph","family":"Kamgno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick Nguipdop","family":"Djomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien 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