{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:32:53Z","timestamp":1787031173275,"version":"build-2736575974"},"reference-count":17,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p>\n                    This study assessed adrenal function in patients with paracoccididioidomycosis who had been treated to determine a possible connection between high antibody titers and adrenal dysfunction attributable to persistence of the fungus in adrenal gland. Adrenal gland function was studied in 28 previously treated patients, 2 (7.1%) of whom were shown to have adrenal insufficiency and 7 (259%) who showed a below normal response to stimuli by adrenocorticotropic hormone.\n                    <jats:italic>Paracoccidioides brasiliensis<\/jats:italic>\n                    was detected in the adrenal gland from one of the patients with adrenal insufficiency. Although the study failed to demonstrate a significant difference between high antibody titers and low cortisol levels, the proportion of adrenal insufficiency detected and the subnormal response to adrenocorticotropic hormone confirmed that adrenal damage is an important sequela of paracoccidioidomycosis. Studies with a larger number of patients should be conducted to confirm the hypothesis of persistence of\n                    <jats:italic>P. brasiliensis<\/jats:italic>\n                    in adrenal gland after therapy.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.2010.09-0634","type":"journal-article","created":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T12:25:01Z","timestamp":1277987101000},"page":"111-114","source":"Crossref","is-referenced-by-count":20,"title":["Adrenal Function Status in Patients with Paracoccidioidomycosis after Prolonged Post-Therapy Follow-Up"],"prefix":"10.4269","volume":"83","author":[{"given":"Angela M.","family":"Tob\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Agudelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Quiceno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Estrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Bailliere's Clin Trop Med Commun Dis","first-page":"185","article-title":"Paracoccidioidomycosis","volume":"4","author":"Franco","year":"1989"},{"key":"R2","series-title":"Principles and Practice of Infectious Diseases","first-page":"3062","author":"Restrepo","year":"2005"},{"key":"R3","series-title":"Diagnosis and Treatment of Human Mycoses","first-page":"331","author":"Restrepo","year":"2008"},{"key":"R4","series-title":"Ann Intern Med","first-page":"189","article-title":"Addison's disease associated with South American blastomycosis","volume":"54","author":"Del Negro","year":"1961"},{"key":"R5","series-title":"Biomedica (Bogota)","first-page":"280","article-title":"Insuficiencia suprarenal secundaria a paracoccidioidomicosis","volume":"22","author":"O\u00f1ate","year":"2002"},{"key":"R6","series-title":"Paracoccioidomycosis","first-page":"303","author":"Tendrich","year":"1993"},{"key":"R7","series-title":"Virchows Arch A Pathol Pathol Anat","first-page":"51","article-title":"Paracoccidioidomycosis; anatomic study with complete autopsies","volume":"348","author":"Salfelder","year":"1969"},{"key":"R8","series-title":"AJR Am J Roentgenol","first-page":"461","article-title":"Addison's disease caused by Paracoccidioides brasiliensis: diagnosis by needle aspiration biopsy of the adrenal gland","volume":"166","author":"Fai\u00e7al","year":"1996"},{"key":"R9","series-title":"J Clin Microbiol","first-page":"3309","article-title":"Antigenemia in patients with paracoccidioidomycosis: detection of the 87-kilodalton determinant during and after antifungal therapy","volume":"36","author":"Gomez","year":"1998"},{"key":"R10","series-title":"Mycopathologia","first-page":"89","article-title":"Systematic evaluation of the adrenocortical function in patients with paracoccidioidomycosis","volume":"127","author":"Colombo","year":"1994"},{"key":"R11","series-title":"N Engl J Med","first-page":"1206","article-title":"Adrenal insufficiency","volume":"335","author":"Oelkers","year":"1996"},{"key":"R12","series-title":"Williams Textbook of Endocrinology","first-page":"445","author":"Stewart","year":"2007"},{"key":"R13","series-title":"BioDrugs","first-page":"107","article-title":"Autoimmune adrenal insufficiency: recognition and management","volume":"13","author":"Winqvist","year":"2000"},{"key":"R14","series-title":"Tratado de Micologia M\u00e9dica Lacaz","first-page":"639","author":"Lacaz","year":"2002"},{"key":"R15","series-title":"Clinical Mycology","first-page":"328","author":"Restrepo-Moreno","year":"2003"},{"key":"R16","series-title":"Mycopathologia","first-page":"289","article-title":"Serology of paracoccidioidomycosis","volume":"165","author":"Camargo","year":"2008"},{"key":"R17","series-title":"Rev Inst Med Trop Sao Paulo","first-page":"45","article-title":"Identification of Paracoccidioides brasiliensis in adrenal glands biopsies of two patients with paracoccioidomycosis and adrenal insufficiency","volume":"51","author":"Agudelo","year":"2009"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/83\/1\/article-p111.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/83\/1\/article-p111.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/83\/1\/article-p111.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T11:58:25Z","timestamp":1725278305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/83\/1\/article-p111.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":17,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.2010.09-0634","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}