{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:09:31Z","timestamp":1791202171272,"version":"4.2.0"},"reference-count":62,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,5]]},"abstract":"<jats:p>Acute febrile illnesses comprise the majority of the human disease burden in sub-Saharan Africa. We hypothesized that arboviruses comprised a considerable proportion of undiagnosed febrile illnesses in Guinea and sought to determine the frequency of arboviral disease in two hospitals there. Using a standard case definition, 47 suspected cases were detected in approximately 4 months. Immunoglobulin M antibody capture enzyme-linked immunosorbent assays and plaque-reduction neutralization assays revealed that 63% (30\/47) of patients were infected with arboviruses, including 11 West Nile, 2 yellow fever, 1 dengue, 8 chikungunya, and 5 Tahyna infections. Except for yellow fever, these are the first reported cases of human disease from these viruses in Guinea and the first reported cases of symptomatic Tahyna infection in Africa. These results strongly suggest that arboviruses circulate and are common causes of disease in Guinea. Improving surveillance and laboratory capacity for arbovirus diagnoses will be integral to understanding the burden posed by these agents in the region.<\/jats:p>","DOI":"10.4269\/ajtmh.2010.09-0688","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T19:18:56Z","timestamp":1280863136000},"page":"388-394","source":"Crossref","is-referenced-by-count":63,"title":["Acute Arboviral Infections in Guinea, West Africa, 2006"],"prefix":"10.4269","volume":"83","author":[{"given":"Emily S.","family":"Jentes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaimie","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara W.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahima","family":"Conde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosse","family":"Sakouvougui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Iverson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanna","family":"Beecher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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II. Arboviruses","volume":"43","author":"Konstantinov","year":"1990"},{"key":"R16","series-title":"Serological investigation of population from the People's Revolutionary Republic of Guinea for antibodies to viral haemorrhagic fevers. Proceedings of the 11th International Congress for Tropical Medicine and Malaria","author":"Tkachenko","year":"1984"},{"key":"R17","series-title":"Med Trop (Mars)","first-page":"303","article-title":"Cholera in Guinea: the 1994\u20131995 epidemic","volume":"59","author":"Boiro","year":"1999"},{"key":"R18","series-title":"Bull Soc Pathol Exot Filiales","first-page":"62","article-title":"Isolation of Rift Valley fever virus from bats in the Republic of Guinea","volume":"80","author":"Boiro","year":"1987"},{"key":"R19","series-title":"Bull Soc Pathol Exot Filiales","first-page":"607","article-title":"Clinico-epidemiologic and laboratory research on hemorrhagic fevers in Guinea","volume":"80","author":"Boiro","year":"1987"},{"key":"R20","series-title":"Bull Soc Pathol Exot Filiales","first-page":"187","article-title":"Isolation of a new orbivirus Kindia (Palyam group) from ticks Amblyomma variegatum in the Republic of Guinea","volume":"79","author":"Boiro","year":"1986"},{"key":"R21","series-title":"Bull Soc Pathol Exot Filiales","first-page":"452","article-title":"Isolation of M'Poko virus (Turlock group, Bunyaviridae) from Culex cinereus mosquitoes in the Republic of Guinea","volume":"78","author":"Boiro","year":"1985"},{"key":"R22","series-title":"Med Parazitol (Mosk)","first-page":"64","article-title":"Ticks of the family Ixodidae in Guinea and the isolation of arboviruses. 1. Species composition of ticks","volume":"2","author":"Konstantinov","year":"1988"},{"key":"R23","series-title":"Vector Borne Zoonotic Dis","first-page":"269","article-title":"Lassa fever in Guinea: I. Epidemiology of human disease and clinical observations","volume":"1","author":"Bausch","year":"2001"},{"key":"R24","series-title":"Clin Diagn Lab Immunol","first-page":"544","article-title":"Use of immunoglobulin m cross-reactions in differential diagnosis of human flaviviral encephalitis infections in the United States","volume":"9","author":"Martin","year":"2002"},{"key":"R25","series-title":"J Clin Microbiol","first-page":"1823","article-title":"Standardization of immunoglobulin M capture enzyme-linked immunosorbent assays for routine diagnosis of arboviral infections","volume":"38","author":"Martin","year":"2000"},{"key":"R26","series-title":"Diagnostic Procedures for Viral, Rickettsial, and Chlamydial Infections","first-page":"189","author":"Beaty","year":"1995"},{"key":"R27","series-title":"Guidelines for Plaque Reduction Neutralizing Testing of Human Antibodies to Dengue Viruses","author":"World Health Organization","year":"2007"},{"key":"R28","series-title":"J Clin Microbiol","first-page":"503","article-title":"Serum dilution neutralization test for California group virus identification and serology","volume":"4","author":"Lindsey","year":"1976"},{"key":"R29","series-title":"J Gen Virol","first-page":"37","article-title":"Antigenic relationships between flaviviruses as determined by cross-neutralization tests with polyclonal antisera","volume":"70","author":"Calisher","year":"1989"},{"key":"R30","series-title":"Wkly Epidemiol Rec","first-page":"249","article-title":"The yellow fever situation in Africa and South America in 2004","volume":"80","author":"Anonymous","year":"2005"},{"key":"R31","series-title":"Outbreaks of Yellow Fever","author":"Anonymous","year":"2009"},{"key":"R32","series-title":"Med Parazitol (Mosk)","first-page":"34","article-title":"The mammals of Guinea as reservoirs and carriers of arboviruses","author":"Konstantinov","year":"2006"},{"key":"R33","series-title":"\u00c9pid\u00e9miologie de l'infection par le virus Chikungunya \u00e0 l'Ile de la R\u00e9union: point de la situation au 8 janvier 2006","author":"Paquet","year":"2006"},{"key":"R34","series-title":"J Clin Virol","first-page":"1217","article-title":"Alphaviruses","author":"Tsai","year":"1997"},{"key":"R35","series-title":"Bull Soc Pathol Exot","first-page":"79","article-title":"Chikungunya virus outbreak in Senegal in 1996 and 1997","volume":"92","author":"Thonnon","year":"1999"},{"key":"R36","series-title":"Essentials of Tropical Infectious Disease","first-page":"587","author":"Weaver","year":"2006"},{"key":"R37","series-title":"Trans R Soc Trop Med Hyg","first-page":"553","article-title":"Survey for antibodies against arthropod-borne viruses in the sera of indigenous residents of the Caprivi Strip and Bechuanaland Protectorate","volume":"59","author":"Kokernot","year":"1965"},{"key":"R38","series-title":"An Inst Med Trop (Lisb)","first-page":"201","article-title":"Neutralization tests with sera from individuals residing in Mozambique against specific viruses isolated in Africa, transmitted by arthropods","volume":"17","author":"Kokernot","year":"1960"},{"key":"R39","series-title":"Trans R Soc Trop Med Hyg","first-page":"704","article-title":"Chikungunya fever as a risk factor for endemic Burkitt's lymphoma in Malawi","volume":"94","author":"van den Bosch","year":"2000"},{"key":"R40","series-title":"Bull Soc Pathol Exot Filiales","first-page":"155","article-title":"Human arbovirus infections in Burundi: results of a seroepidemiologic survey, 1980\u20131982","volume":"80","author":"Rodhain","year":"1987"},{"key":"R41","series-title":"Trans R Soc Trop Med Hyg","first-page":"149","article-title":"Arthropod-borne virus antibodies in sera of residents of Kainji Lake Basin, Nigeria 1980","volume":"77","author":"Adekolu-John","year":"1983"},{"key":"R42","series-title":"Trans R Soc Trop Med Hyg","first-page":"5","article-title":"Isolation of dengue 2 and dengue 4 viruses from patients in Senegal","volume":"80","author":"Saluzzo","year":"1986"},{"key":"R43","series-title":"J Med Entomol","first-page":"623","article-title":"Dengue 2 outbreak in southeastern Senegal during 1990: virus isolations from mosquitoes (Diptera: Culicidae)","volume":"31","author":"Traore-Lamizana","year":"1994"},{"key":"R44","series-title":"Emerg Infect Dis","first-page":"83","article-title":"Isolation of a dengue type 1 virus from a soldier in West Africa (Cote d'Ivoire)","volume":"6","author":"Durand","year":"2000"},{"key":"R45","series-title":"Ann Inst Pasteur Virol","first-page":"233","article-title":"Isolement de 96 souches de virus dengue 2 a partir de moustiques captures en Cote d'Ivoire et Haute-Volta","volume":"134E","author":"Roche","year":"1983"},{"key":"R46","series-title":"Ent Med et Parasitol","first-page":"165","article-title":"Circulation selvatique du virus dengue 2 en 1980, dans les savanes sub-soudaniennes de Cote 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