{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:22:00Z","timestamp":1761488520279},"reference-count":30,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,5]]},"abstract":"<jats:p>One small previous study found that praziquantel reduced hookworm infection. In this study, 607 subjects were enrolled in a longitudinal study. At enrollment and every 3 months for 18 months, three stool samples were collected, and the intensity of infection with <jats:italic>Schistosoma japonicum<\/jats:italic> and soil-transmitted helminths (STHs) was quantified. All subjects were treated with 60 mg\/kg praziquantel at baseline. Three months post-treatment, the percent of subjects who were hookworm-infected decreased to 46.5% from 61% at baseline. The putative cure rate was 23.7%. The 95% confidence interval around the change in hookworm egg counts from baseline to 6 and 12 months post-treatment was negative and did not include zero. The percent reduction in hookworm egg counts from baseline to 3 months post-treatment was 40.8%. Praziquantel treatment did not decrease the infection intensity of STHs. Control programs using praziquantel may have the added benefit of reducing hookworm infection and anemia in areas of coendemnicity.<\/jats:p>","DOI":"10.4269\/ajtmh.2010.09-0700","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T19:18:56Z","timestamp":1280863136000},"page":"416-421","source":"Crossref","is-referenced-by-count":7,"title":["Reduction in Hookworm Infection after Praziquantel Treatment among Children and Young Adults in Leyte, the Philippines"],"prefix":"10.4269","volume":"83","author":[{"given":"Julia G.","family":"Shaw","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitin","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz P.","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario A.","family":"Jiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tjalling","family":"Leenstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah M.","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remigio M.","family":"Olveda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Kurtis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen T.","family":"McGarvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer F.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Lancet","first-page":"1521","article-title":"Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm","volume":"367","author":"Bethony","year":"2006"},{"key":"R2","series-title":"PLoS Negl Trop Dis","first-page":"e412","article-title":"Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden","volume":"3","author":"Hotez","year":"2009"},{"key":"R3","series-title":"J Am Med Assoc","first-page":"1937","article-title":"Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis","volume":"299","author":"Keiser","year":"2008"},{"key":"R4","series-title":"Int J Parasitol","first-page":"759","article-title":"Reduction in the prevalence and intensity of hookworm infections after praziquantel treatment for schistosomiasis infection","volume":"32","author":"Utzinger","year":"2002"},{"key":"R5","series-title":"Mutat Res","first-page":"123","article-title":"Genotoxic activity of praziquantel","volume":"387","author":"Montero","year":"1997"},{"key":"R6","series-title":"Parasitology","first-page":"59","article-title":"Praziquantel: physiological evidence for its site(s) of action in magnesium-paralysed Schistosoma mansoni","volume":"104","author":"Blair","year":"1992"},{"key":"R7","series-title":"Exp Parasitol","first-page":"242","article-title":"Schistosoma mansoni: molecular cloning and sequencing of the 200-kDa chemotherapeutic target antigen","volume":"80","author":"Hall","year":"1995"},{"year":"2006","series-title":"Preventive Chemotherapy in Human Helminthiasis. 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