{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:44:05Z","timestamp":1793904245893,"version":"4.8.0"},"reference-count":54,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p>Rats are known to be the most important reservoirs and transmission sources of leptospirosis. However, the status of leptospirosis in the Philippines regarding reservoirs and transmission remains unknown. A survey was conducted in Metro Manila and Laguna that analyzed samples obtained from 106 rats. Using the microscopic agglutination test, we found that 92% of rat serum samples were positive for anti-<jats:italic>Leptospira<\/jats:italic> antibodies; the most common infecting serovars were Manilae, Hebdomadis, and Losbanos. On the basis of pulsed-field gel electrophoresis and gyrase B gene sequence analyses, four groups of rat kidney isolates were found: <jats:italic>L. interrogans<\/jats:italic> serovar Manilae, serovar Losbanos, and serogroup Grippotyphosa, and <jats:italic>L. borgpetersenii<\/jats:italic> serogroup Javanica. Most isolates were lethal after experimental infection of golden Syrian hamsters. Results showed that these four <jats:italic>Leptospira<\/jats:italic> serovars and serogroups are circulating among rats, and that these animals may be one of the possible transmission sources of leptospirosis in the Philippines.<\/jats:p>","DOI":"10.4269\/ajtmh.2010.09-0711","type":"journal-article","created":{"date-parts":[[2010,5,4]],"date-time":"2010-05-04T01:02:37Z","timestamp":1272934957000},"page":"889-898","source":"Crossref","is-referenced-by-count":81,"title":["Serologic and Molecular Studies of Leptospira and Leptospirosis among Rats in the Philippines"],"prefix":"10.4269","volume":"82","author":[{"given":"Sharon Y. A. M.","family":"Villanueva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Ezoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubelia A.","family":"Baterna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutake","family":"Yanagihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Muto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Koizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Masuzawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lolita L.","family":"Cavinta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina G.","family":"Gloriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Southeast Asian J Trop Med Public Health","first-page":"482","article-title":"Studies on leptospirosis in animals and man in the Philippines V. 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