{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T02:29:21Z","timestamp":1768271361886,"version":"3.49.0"},"reference-count":29,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,5]]},"abstract":"<jats:p>Control of human African trypanosomiasis (HAT) in the Democratic Republic of Congo is based on mass population screening by mobile teams; a costly and labor-intensive approach. We hypothesized that blood samples collected on filter paper by village health workers and processed in a central laboratory might be a cost-effective alternative. We estimated sensitivity and specificity of micro-card agglutination test for trypanosomiasis (micro-CATT) and enzyme-linked immunosorbent assay (ELISA)\/<jats:italic>T.b. gambiense<\/jats:italic> on filter paper samples compared with parasitology-based case classification and used the results in a Monte Carlo simulation of a lot quality assurance sampling (LQAS) approach. Micro-CATT and ELISA\/<jats:italic>T.b. gambiense<\/jats:italic> showed acceptable sensitivity (92.7% [95% CI 87.4\u201398.0%] and 82.2% [95% CI 75.3\u201390.4%]) and very high specificity (99.4% [95% CI 99.0\u201399.9%] and 99.8% [95% CI 99.5\u2013100%]), respectively. Conditional on high sample size per lot (\u2265 60%), both tests could reliably distinguish a 2% from a zero prevalence at village level. Alternatively, these tests could be used to identify individual HAT suspects for subsequent confirmation.<\/jats:p>","DOI":"10.4269\/ajtmh.2010.09-0735","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T19:18:56Z","timestamp":1280863136000},"page":"374-379","source":"Crossref","is-referenced-by-count":25,"title":["Diagnostic Accuracy and Feasibility of Serological Tests on Filter Paper Samples for Outbreak Detection of T.b. gambiense Human African Trypanosomiasis"],"prefix":"10.4269","volume":"83","author":[{"given":"Epco","family":"Hasker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Lutumba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieudonn\u00e9","family":"Mumba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veerle","family":"Lejon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillipe","family":"B\u00fcscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Kande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Jacques","family":"Muyembe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joris","family":"Menten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Robays","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marleen","family":"Boelaert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Lancet","first-page":"148","article-title":"Human African trypanosomiasis","volume":"375","author":"Brun","year":"2009"},{"key":"R2","series-title":"World Health Organ Tech Rep Ser","first-page":"I","article-title":"Control and surveillance of African trypanosomiasis. 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