{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:19:29Z","timestamp":1788459569087,"version":"build-2803163510"},"reference-count":105,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p>\n                    Pemphigus foliaceus is a life threatening skin disease that is associated with autoimmunity to desmoglein, a skin protein involved in the adhesion of keratinocytes. This disease is endemic in certain areas of South America, suggesting the mediation of environmental factors triggering autoimmunity. Among the possible environmental factors, exposure to bites of black flies, in particular\n                    <jats:italic>Simulium nigrimanum<\/jats:italic>\n                    has been suggested. In this work, we describe the sialotranscriptome of adult female\n                    <jats:italic>S. nigrimanum<\/jats:italic>\n                    flies. It reveals the complexity of the salivary potion of this insect, comprised by over 70 distinct genes within over 30 protein families, including several novel families, even when compared with the previously described sialotranscriptome of the autogenous black fly,\n                    <jats:italic>S. vittatum.<\/jats:italic>\n                    The uncovering of this sialotranscriptome provides a platform for testing pemphigus patient sera against recombinant salivary proteins from\n                    <jats:italic>S. nigrimanum<\/jats:italic>\n                    and for the discovery of novel pharmacologically active compounds.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.2010.09-0769","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T15:04:52Z","timestamp":1275491092000},"page":"1060-1075","source":"Crossref","is-referenced-by-count":29,"title":["An Insight into the Sialotranscriptome of Simulium nigrimanum, a Black Fly Associated with Fogo Selvagem in South America"],"prefix":"10.4269","volume":"82","author":[{"given":"Jos\u00e9 M. C.","family":"Ribeiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus G.","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van M.","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Kleeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent D.","family":"Barbian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Favreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald P.","family":"Eaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter","family":"Hans-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evandro A.","family":"Rivitti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"J Autoimmun","first-page":"311","article-title":"Advances in pemphigus and its endemic pemphigus foliaceus (Fogo Selvagem) phenotype: a paradigm of human autoimmunity","volume":"31","author":"Culton","year":"2008"},{"key":"R2","series-title":"J Invest Dermatol","first-page":"2823","article-title":"Antigen selection of anti-DSG1 autoantibodies during and before the onset of endemic pemphigus foliaceus","volume":"129","author":"Qian","year":"2009"},{"key":"R3","series-title":"J Clin Invest","first-page":"296","article-title":"Monovalent Fab' immunoglobulin fragments from endemic pemphigus foliaceus autoantibodies reproduce the human disease in neonatal Balb\/c mice","volume":"85","author":"Rock","year":"1990"},{"key":"R4","series-title":"J Invest Dermatol","first-page":"2044","article-title":"Prevalence of anti-desmoglein-3 antibodies in endemic regions of Fogo selvagem in Brazil","volume":"126","author":"Hilario-Vargas","year":"2006"},{"key":"R5","series-title":"J Med Entomol","first-page":"120","article-title":"Comparison of black fly species (Diptera: Simuliidae) on an Amerindian reservation with a high prevalence of fogo selvagem to neighboring disease-free sites in the State of Mato Grosso do Sul, Brazil. 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