{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:26:06Z","timestamp":1791278766950,"version":"4.1.0"},"reference-count":12,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p>Two cases of yellow fever vaccine-associated viscerotropic adverse events (YEL-AVD) were identified by review of correspondence received at the Centers for Disease Control and Prevention (CDC; Ft. Collins, CO). The cases occurred in Indiana and Maryland in 1973 and 1978, respectively. One patient, a 75-year-old man with multi-organ failure died, and the other, a 31-year-old woman, was hospitalized for 14 days. Onset was 3\u20136 days after vaccination. The illness was characterized by fever, headache, myalgia, gastrointestinal symptoms, hepatic and renal dysfunction, and (in the fatal case), shock and coagulopathy, compatible with YEL-AVD. Liver pathology showed diffuse, spotty necrosis, acidophilic degeneration, Kupffer cell hyperplasia, and microvesicular fat. No virological confirmation was obtained, so that both cases remain classified as \u201csuspect.\u201d The 1973 case is the earliest record of YEL-AVD; until now, the earliest known case of YEL-AVD had been in 1975 in Brazil, and most subsequent cases have been reported after 1995.<\/jats:p>","DOI":"10.4269\/ajtmh.2010.10-0001","type":"journal-article","created":{"date-parts":[[2010,5,4]],"date-time":"2010-05-04T01:02:37Z","timestamp":1272934957000},"page":"919-921","source":"Crossref","is-referenced-by-count":31,"title":["Suspected Yellow Fever Vaccine-Associated Viscerotropic Adverse Events (1973 and 1978), United States"],"prefix":"10.4269","volume":"82","author":[{"given":"Thomas P.","family":"Monath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"J Exp Med","first-page":"787","article-title":"The use of yellow fever virus modified by in vitro cultivation for human immunization","volume":"65","author":"Theiler","year":"1937"},{"key":"R2","series-title":"Am J Trop Med Hyg","first-page":"533","article-title":"Comparative safety and immunogenicity of two yellow fever 17D vaccines (ARILVAX and YF-VAX) in a phase III multicenter, double-blind clinical trial","volume":"66","author":"Monath","year":"2002"},{"key":"R3","series-title":"Lancet","first-page":"98","article-title":"Multisystemic illness in elderly recipients of yellow fever vaccine: report of four cases","volume":"358","author":"Martin","year":"2001"},{"key":"R4","series-title":"Lancet","first-page":"91","article-title":"Serious adverse events associated with yellow fever 17DD vaccine in Brazil: a report of two cases","volume":"358","author":"Vasconcelos","year":"2001"},{"key":"R5","series-title":"Lancet","first-page":"121","article-title":"Hepatitis and death following vaccination with 17D-204 yellow fever vaccine","volume":"358","author":"Chan","year":"2001"},{"key":"R6","series-title":"Trans R Soc Trop Med Hyg","first-page":"967","article-title":"Acute viscerotropic disease following vaccination against yellow fever","volume":"101","author":"Hayes","year":"2007"},{"key":"R7","series-title":"Vaccines","first-page":"959","author":"Monath","year":"2008"},{"key":"R8","series-title":"Vaccine","first-page":"6077","article-title":"Adverse event reports following yellow fever vaccination","volume":"26","author":"Lindsey","year":"2008"},{"key":"R9","series-title":"J Infect Dis","first-page":"500","article-title":"Case of yellow fever vaccine\u2013associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes","volume":"198","author":"Pulendran","year":"2008"},{"key":"R10","series-title":"Lancet","first-page":"936","article-title":"History of thymoma and yellow fever vaccination","volume":"364","author":"Barwick","year":"2004"},{"key":"R11","series-title":"Vaccine","first-page":"1073","article-title":"Characterization of a viscerotropic yellow fever vaccine variant from a patient in Brazil","volume":"22","author":"Engel","year":"2004"},{"key":"R12","series-title":"Vaccine","first-page":"5974","article-title":"Viscerotropic disease following yellow fever vaccination in Peru","volume":"27","author":"Whittembury","year":"2009"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/82\/5\/article-p919.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/82\/5\/article-p919.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/82\/5\/article-p919.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T15:54:51Z","timestamp":1725292491000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/82\/5\/article-p919.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":12,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.2010.10-0001","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}