{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T01:28:44Z","timestamp":1782005324661,"version":"3.54.5"},"reference-count":13,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,5]]},"abstract":"<jats:p>Severe rhabdomyolysis (creatine phosphokinase = 29,400U\/L) developed in a 16-year-old boy from Manaus, Brazil, after he started treatment with chloroquine for infection with <jats:italic>Plasmodium vivax<\/jats:italic>. Treatment led to myoglobinuria and acute renal failure. After hemodialysis, the patient improved and a muscle biopsy specimen showed no myophosphorylase or deaminase deficiency. This case of rhabdomyolysis associated with <jats:italic>P. vivax<\/jats:italic> infection showed no comorbidities. The pathogenesis is still unclear.<\/jats:p><jats:p>Although rhabdomyolysis is generally reported as a complication of <jats:italic>Plasmodium falciparum<\/jats:italic> malaria, leading to metabolic and renal complications,1 it has been reported in a patient with <jats:italic>P. vivax<\/jats:italic> infection with myoadenylate deaminase deficiency.2 We report a case in a patient without typical muscle enzyme deficiencies in which severe rhabdomyolysis developed while the patients was being treated with chloroquine for a confirmed <jats:italic>P. vivax<\/jats:italic> infection.<\/jats:p>","DOI":"10.4269\/ajtmh.2010.10-0027","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T19:18:56Z","timestamp":1280863136000},"page":"271-273","source":"Crossref","is-referenced-by-count":21,"title":["Severe Rhabdomyolysis Caused by Plasmodium vivax Malaria in the Brazilian Amazon"],"prefix":"10.4269","volume":"83","author":[{"given":"Andr\u00e9 M.","family":"Siqueira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia A. A.","family":"Alexandre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria P. G.","family":"Mour\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valquir S.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suely K.","family":"Nagahashi-Marie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G. C.","family":"Alecrim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus V. G.","family":"Lacerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Clin Infect Dis","first-page":"831","article-title":"Skeletal muscle involvement in falciparum malaria: biochemical and ultrastructural study","volume":"29","author":"Davis","year":"1999"},{"key":"R2","series-title":"Trop Geogr Med","first-page":"83","article-title":"Rhabdomyolysis associated with malaria tertiana in a patient with myoadenylate deaminase deficiency","volume":"45","author":"Poels","year":"1993"},{"key":"R3","series-title":"Mol Biochem Parasitol","first-page":"315","article-title":"High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction","volume":"61","author":"Snounou","year":"1993"},{"key":"R4","series-title":"Br Med J (Clin Res Ed)","first-page":"1039","article-title":"Skeletal muscle necrosis in severe falciparum malaria","volume":"296","author":"Silva","year":"1988"},{"key":"R5","series-title":"J Neurol Neurosurg Psychiatry","first-page":"1328","article-title":"Malaria myositis","volume":"56","author":"Swash","year":"1993"},{"key":"R6","series-title":"Am J Trop Med Hyg","first-page":"194","article-title":"Severe Plasmodium vivax malaria: a report on serial cases from Bikaner in northwestern India","volume":"80","author":"Kochar","year":"2009"},{"key":"R7","series-title":"Ann Rheum Dis","first-page":"385","article-title":"Antimalarial myopathy: an underdiagnosed complication? Prospective longitudinal study of 119 patients","volume":"65","author":"Casado","year":"2006"},{"key":"R8","series-title":"Trends Parasitol","first-page":"220","article-title":"The pathophysiology of vivax malaria","volume":"25","author":"Anstey","year":"2009"},{"key":"R9","series-title":"Acta Trop","first-page":"271","article-title":"Progression of skeletal muscle damage during treatment of severe falciparum malaria","volume":"76","author":"Davis","year":"2000"},{"key":"R10","series-title":"Unfallchirurg","first-page":"415","article-title":"Rhabdomyolysis after administration of diclofenac","volume":"108","author":"Knobloch","year":"2005"},{"key":"R11","series-title":"Am J Med Sci","first-page":"95","article-title":"Case report: diclofenac-induced rhabdomyolysis","volume":"312","author":"Delrio","year":"1996"},{"key":"R12","series-title":"Epidemiology of Malaria in Brazil, 2007","author":"Brazilian Ministry of Health, 2008"},{"key":"R13","series-title":"Acta Trop","first-page":"187","article-title":"Idiopathic thrombocytopenic purpura due to vivax malaria in the Brazilian Amazon","volume":"90","author":"Lacerda","year":"2004"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/83\/2\/article-p271.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/83\/2\/article-p271.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/83\/2\/article-p271.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T15:59:31Z","timestamp":1725292771000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/83\/2\/article-p271.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,5]]},"references-count":13,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.2010.10-0027","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,5]]}}}