{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:11:23Z","timestamp":1791825083941,"version":"4.3.4"},"reference-count":13,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,5]]},"abstract":"<jats:p>Neurognathostomiasis is a rare but severe form of human gnathostomiasis. Diagnosis of neurognathostomiasis is made presumably by using clinical manifestations. Serologic tests for neurognathostomiasis are not widely available and limited. We studied 12 patients with diagnoses of neurognathostomiasis at Srinagarind Hospital, Khon Kaen University, Thailand. There were three types of neurognathostomiasis (five patients with intracerebral hemorrhage, one patient with subarachnoid hemorrhage, and six patients with myelitis). All patients were tested for antibodies against <jats:italic>Gnathostoma spinigerum<\/jats:italic> by an immunoblotting technique. The sensitivity and specificity of the 21-kD and 24-kD diagnostic bands were 83.3% and 100%, and 91.7% and 100%, respectively. The sensitivity, specificity, positive predictive value, and negative predictive value for the 21-kD and 24-kD diagnostic bands were all 100%. Both diagnostic bands are a helpful diagnostic tool for neuro gnathostomiasis and show good diagnostic properties.<\/jats:p>","DOI":"10.4269\/ajtmh.2010.10-0113","type":"journal-article","created":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T17:15:08Z","timestamp":1285953308000},"page":"927-929","source":"Crossref","is-referenced-by-count":24,"title":["Immunoblot Diagnostic Test for Neurognathostomiasis"],"prefix":"10.4269","volume":"83","author":[{"given":"Pewpan M.","family":"Intapan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyarat","family":"Khotsri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaturat","family":"Kanpittaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verajit","family":"Chotmongkol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kittisak","family":"Sawanyawisuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanchai","family":"Maleewong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Southeast Asian J Trop Med Public Health","first-page":"217","article-title":"Historical review and current status of gnathostomiasis in Asia","volume":"22","author":"Nawa","year":"1991"},{"key":"R2","series-title":"Am J Trop Med Hyg","first-page":"316","article-title":"Gnathostomiasis in Mexico","volume":"58","author":"Ogata","year":"1998"},{"key":"R3","series-title":"Am J Trop Med Hyg","first-page":"623","article-title":"Treatment of cutaneous gnathostomiasis with ivermectin","volume":"71","author":"Kraivichian","year":"2004"},{"key":"R4","series-title":"West J Med","first-page":"65","article-title":"CT-evidence of subarachnoid hemorrhage due to presumed gnathostomiasis","volume":"137","author":"Brant-Zawadzki","year":"1982"},{"key":"R5","series-title":"Trans R Soc Trop Med Hyg","first-page":"102","article-title":"Sequential imaging studies of cerebral gnathostomiasis with subdural hemorrhage as its complication","volume":"103","author":"Sawanyawisuth","year":"2009"},{"key":"R6","series-title":"N Engl J Med","first-page":"188","article-title":"Images in clinical medicine. Gnathostomiasis\u2014neuroimaging of larval migration","volume":"353","author":"Sithinamsuwan","year":"2005"},{"key":"R7","series-title":"AJNR Am J Neuroradiol","first-page":"39","article-title":"MR imaging findings in cauda equina gnathostomiasis","volume":"26","author":"Sawanyawisuth","year":"2005"},{"key":"R8","series-title":"AJNR Am J Neuroradiol","first-page":"446","article-title":"MR imaging findings in cerebrospinal gnathostomiasis","volume":"25","author":"Sawanyawisuth","year":"2004"},{"key":"R9","series-title":"J Neurol Sci","first-page":"279","article-title":"Neurological manifestations of gnathostomiasis","volume":"31","author":"Boongird","year":"1977"},{"key":"R10","series-title":"Clin Infect Dis","first-page":"33","article-title":"Clinical gnathostomiasis: case report and review of the English language literature","volume":"16","author":"Rusnak","year":"1993"},{"key":"R11","series-title":"Trop Med Int Health","first-page":"1013","article-title":"Diagnostic values of IgG4 in human gnathostomiasis","volume":"10","author":"Anantaphruti","year":"2005"},{"key":"R12","series-title":"Parasitol Res","first-page":"703","article-title":"Evaluation of human IgG class and subclass antibodies to a 24 kDa antigenic component of Gnathostoma spinigerum for the serodiagnosis of gnathostomiasis","volume":"101","author":"Laummaunwai","year":"2007"},{"key":"R13","series-title":"Int J Parasitol","first-page":"315","article-title":"Specific antigen of Gnathostoma spinigerum for immunodiagnosis of human gnathostomiasis","volume":"21","author":"Tapchaisri","year":"1991"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/83\/4\/article-p927.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/83\/4\/article-p927.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/83\/4\/article-p927.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T16:24:09Z","timestamp":1725294249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/83\/4\/article-p927.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,5]]},"references-count":13,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.2010.10-0113","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,5]]}}}