{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:27:42Z","timestamp":1775057262814,"version":"3.50.1"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,5]]},"abstract":"<jats:p>The aim of this study was to examine retrospective dengue-illness classification using only clinical laboratory data, without relying on X-ray, ultrasound, or percent hemoconcentration. We analyzed data from a study of children who presented with acute febrile illness to two hospitals in Thailand. Multivariable logistic regression models were used to distinguish: (1) dengue hemorrhagic fever (DHF) versus dengue fever (DF), (2) DHF versus DF + other febrile illness (OFI), (3) dengue versus OFI, and (4) severe dengue versus non-severe dengue + OFI. Data from the second hospital served as a validation set. There were 1,227 patients in the analysis. The sensitivity of the models ranged from 89.2% (dengue versus OFI) to 79.6% (DHF versus DF). The models showed high sensitivity in the validation dataset. These models could be used to calculate a probability and classify patients based on readily available clinical laboratory data, and they will need to be validated in other dengue-endemic regions.<\/jats:p>","DOI":"10.4269\/ajtmh.2010.10-0135","type":"journal-article","created":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T17:15:08Z","timestamp":1285953308000},"page":"781-788","source":"Crossref","is-referenced-by-count":20,"title":["Classification of Dengue Illness Based on Readily Available Laboratory Data"],"prefix":"10.4269","volume":"83","author":[{"given":"James A.","family":"Potts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anon","family":"Srikiatkhachorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pra-on","family":"Supradish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ananda","family":"Nisalak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suchitra","family":"Nimmannitya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy P.","family":"Endy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H.","family":"Libraty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert V.","family":"Gibbons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharone","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan L.","family":"Rothman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siripen","family":"Kalayanarooj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Global Burden of Dengue: Pediatric Dengue Vaccine Initiative","author":"Beatty","year":"2009"},{"key":"R2","series-title":"Southeast Asian J Trop Med Public Health","first-page":"392","article-title":"Clinical spectrum and management of dengue haemorrhagic fever","volume":"18","author":"Nimmannitya","year":"1987"},{"key":"R3","series-title":"Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention, and Control","author":"World Health Organization","year":"1997"},{"key":"R4","series-title":"Am J Trop Med Hyg","first-page":"1059","article-title":"Short report: assessment of the World Health Organization scheme for classification of dengue severity in Nicaragua","volume":"73","author":"Balmaseda","year":"2005"},{"key":"R5","series-title":"Trop Med Int Health","first-page":"1238","article-title":"Classifying dengue: a review of the difficulties in using the WHO case classification for dengue haemorrhagic fever","volume":"11","author":"Bandyopadhyay","year":"2006"},{"key":"R6","series-title":"BMC Infect Dis","first-page":"22","article-title":"Dengue disease severity in Indonesian children: an evaluation of the World Health Organization classification system","volume":"7","author":"Setiati","year":"2007"},{"key":"R7","series-title":"Clin Infect Dis","first-page":"1135","article-title":"Dengue hemorrhagic fever: the sensitivity and specificity of the World Health Organization definition for identification of severe cases of dengue in Thailand, 1994\u20132005","volume":"50","author":"Srikiatkhachorn","year":"2010"},{"key":"R8","series-title":"Trop Med Int Health","first-page":"1328","article-title":"Clinical and laboratory features that distinguish dengue from other febrile illnesses in endemic populations","volume":"13","author":"Potts","year":"2008"},{"key":"R9","series-title":"J Infect Dis","first-page":"313","article-title":"Early clinical and laboratory indicators of acute dengue illness","volume":"176","author":"Kalayanarooj","year":"1997"},{"key":"R10","series-title":"Pediatrics","first-page":"823","article-title":"The maintenance need for water in parenteral fluid therapy","volume":"19","author":"Holliday","year":"1957"},{"key":"R11","series-title":"The Harriet Lane Handbook: A Manual for Pediatric House Officers","author":"Custer","year":"2009"},{"key":"R12","series-title":"Am J Trop Med Hyg","first-page":"5","article-title":"Clinical, epidemiologic, and virologic features of dengue in the 1998 epidemic in Nicaragua","volume":"63","author":"Harris","year":"2000"},{"key":"R13","series-title":"Lancet Infect Dis","first-page":"297","article-title":"Severe dengue: the need for new case definitions","volume":"6","author":"Rigau-Perez","year":"2006"},{"key":"R14","series-title":"P R Health Sci J","first-page":"347","article-title":"An evaluation of modified case definitions for the detection of dengue hemorrhagic fever. Puerto Rico Association of Epidemiologists","volume":"18","author":"Rigau-Perez","year":"1999"},{"key":"R15","series-title":"Lancet Infect Dis","first-page":"81","article-title":"Indian perspective on the need for new case definitions of severe dengue","volume":"7","author":"Thangaratham","year":"2007"},{"key":"R16","series-title":"Am J Trop Med Hyg","first-page":"638","article-title":"Hemostatic changes in Vietnamese children with mild dengue correlate with the severity of vascular leakage rather than bleeding","volume":"81","author":"Wills","year":"2009"},{"key":"R17","series-title":"J Clin Virol","first-page":"75","article-title":"Cross-reactive IgM responses in patients with dengue or Japanese encephalitis","volume":"42","author":"A-Nuegoonpipat","year":"2008"},{"key":"R18","series-title":"Am J Trop Med Hyg","first-page":"418","article-title":"An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis co-circulate","volume":"40","author":"Innis","year":"1989"},{"key":"R19","series-title":"Trop Med Int Health","first-page":"125","article-title":"Evaluation of the World Health Organization standard tourniquet test and a modified tourniquet test in the diagnosis of dengue infection in Viet Nam","volume":"7","author":"Cao","year":"2002"},{"key":"R20","series-title":"Am J Trop Med Hyg","first-page":"172","article-title":"Clinical diagnosis and assessment of severity of confirmed dengue infections in Vietnamese children: is the World Health Organization classification system helpful?","volume":"70","author":"Phuong","year":"2004"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/83\/4\/article-p781.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/83\/4\/article-p781.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/83\/4\/article-p781.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T16:15:05Z","timestamp":1725293705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/83\/4\/article-p781.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,5]]},"references-count":20,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.2010.10-0135","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,5]]}}}