{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T17:10:29Z","timestamp":1725297029775},"reference-count":19,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,5]]},"abstract":"Recent reports from animal models and from cross-sectional studies have suggested that host responses to anti-Lutzomyia longipalpis<\/jats:italic> saliva antibodies may be related to delayed-type hypersensitivity to Leishmania<\/jats:italic> antigen. In a prospective cohort study, we evaluated 1,080 children from two endemic areas for visceral leishmaniasis (VL) by means of Kaplan-Meier analysis. The incidence rate of delayed-type hypersensitivity to Leishmania<\/jats:italic> antigen, measured at the 24th follow-up month, was higher among those reactive to Lu. longipalpis<\/jats:italic> saliva antibodies at the beginning of the study (0.0217 cases per person-month) than among those previously negative (0.0131 cases per person-month) (P<\/jats:italic> value for the log-rank test = 0.0006). It seems that mounting an anti-saliva immune response helps the development of a cell-mediated anti-Leishmania<\/jats:italic> response.<\/jats:p>","DOI":"10.4269\/ajtmh.2010.10-0182","type":"journal-article","created":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T17:15:08Z","timestamp":1285953308000},"page":"825-827","source":"Crossref","is-referenced-by-count":16,"title":["Epidemiological Study of the Association between Anti-Lutzomyia longipalpis Saliva Antibodies and Development of Delayed-Type Hypersensitivity to Leishmania Antigen"],"prefix":"10.4269","volume":"83","author":[{"given":"Dorlene M. C.","family":"Aquino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arlene J. M.","family":"Caldas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Carlos","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio A. M.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel","family":"Barral-Netto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldina","family":"Barral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Wkly Epidemiol Rec","first-page":"6","article-title":"Urbanization: an increasing risk factor for leishmaniasis","volume":"77","author":"World Health Organization","year":"2002"},{"key":"R2","series-title":"Leishmaniose visceral (calazar). Distribui\u00e7\u00e3o de casos confirmados, por Unidade Federada","first-page":"1980","author":"Brazil Minist\u00e9rio da","year":"2006"},{"year":"2010","series-title":"Research to support the elimination of visceral leishmaniasis","author":"World Health Organization","key":"R3"},{"key":"R4","series-title":"Infect Immun","first-page":"1592","article-title":"Analysis of enhancing effect of sand fly saliva on Leishmania infection in mice","volume":"59","author":"Theodos","year":"1991"},{"key":"R5","series-title":"J Exp Med","first-page":"49","article-title":"A mouse model of Leishmania braziliensis braziliensis infection produced by coinjection with sand fly saliva","volume":"173","author":"Samuelson","year":"1991"},{"key":"R6","series-title":"Philos Trans R Soc Lond B Biol Sci","first-page":"223","article-title":"Saliva of Lutzomyia longipalpis sibling species differs in its composition and capacity to enhance leishmaniasis","volume":"345","author":"Warburg","year":"1994"},{"key":"R7","series-title":"Infect Immun","first-page":"5442","article-title":"Effects of sand fly vector saliva on development of cutaneous lesions and the immune response to Leishmania braziliensis in BALB\/c mice","volume":"64","author":"Lima","year":"1996"},{"key":"R8","series-title":"J Exp Med","first-page":"1941","article-title":"Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis","volume":"188","author":"Belkaid","year":"1998"},{"key":"R9","series-title":"Infect Immun","first-page":"1240","article-title":"Sand fly saliva enhances Leishmania amazonensis infection by modulating interleukin-10 production","volume":"72","author":"Norsworthy","year":"2004"},{"key":"R10","series-title":"J Exp Med","first-page":"331","article-title":"Toward a defined anti-Leishmania vaccine 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the development of anti-Leishmania chagasi delayed-type hypersensitivity","volume":"186","author":"Gomes","year":"2002"},{"key":"R15","series-title":"PLoS Negl Trop Dis","first-page":"e226","article-title":"Immunity to distinct sand fly salivary proteins primes the anti-Leishmania immune response towards protection or exacerbation of disease","volume":"2","author":"Oliveira","year":"2002"},{"key":"R16","series-title":"Am J Trop Med Hyg","first-page":"79","article-title":"Selection of a skin test antigen for American visceral leishmaniasis","volume":"35","author":"Reed","year":"1986"},{"key":"R17","series-title":"Am J Trop Med Hyg","first-page":"740","article-title":"Human immune response to sand fly salivary gland antigens: a useful epidemiological marker?","volume":"62","author":"Barral","year":"2000"},{"key":"R18","series-title":"Proc Natl Acad Sci USA","first-page":"6704","article-title":"Delayed-type hypersensitivity to Phlebotomus papatasi sand fly bite: an adaptive response induced by the fly?","volume":"97","author":"Belkaid","year":"2000"},{"key":"R19","series-title":"PLoS Negl Trop Dis","first-page":"e649","article-title":"Using recombinant proteins from Lutzomyia longipalpis saliva to estimate human vector exposure in visceral leishmaniasis endemic areas","volume":"4","author":"Souza","year":"2010"}],"container-title":["The American Society of Tropical Medicine and 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