{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:24:16Z","timestamp":1791293056323,"version":"4.1.0"},"reference-count":12,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,5]]},"abstract":"Edema, parasthesias, and paresis affected 10 residents of an Indian community in Roraima state; three died. Mining with mercury occurs locally; caxir\u00ed, a traditional alcoholic drink, is consumed daily. We conducted a 1:2 unmatched case-control study; a case was an Indian from Uiramut\u00e3 county (population of 9,127) who presented \u2265 1 of lower extremity edema, paresthesias, paresis, or weakness. Controls were asymptomatic Indians randomly selected from the population. We identified 90 cases (prevalence of 1%) and 180 controls; all were enrolled. Among cases, 79% were male, and the median age was 31 years. Ethnicity was Macux\u00ed, and 49% had income. Cases had lower extremity edema (85%), upper extremity paresthesias (84%), and lower extremity weakness and pain (78%). Risk factors were male sex (odds ratio [OR] = 6.8; P<\/jats:italic> < 0.001), age 31\u201340 years (OR = 5.63; P<\/jats:italic> < 0.001), and consumption of caxir\u00ed (OR = 2.7; P<\/jats:italic> < 0.003). Mercury exposure was not a risk. Thiamine therapy produced complete rapid clinical recovery in all cases, confirming the diagnosis of beriberi. We recommend surveillance, thiamine supplementation, and nutritional intervention.<\/jats:p>","DOI":"10.4269\/ajtmh.2010.10-0345","type":"journal-article","created":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T11:28:05Z","timestamp":1288351685000},"page":"1093-1097","source":"Crossref","is-referenced-by-count":22,"title":["Outbreak of Beriberi in an Indian Population of the Upper Amazon Region, Roraima State, Brazil, 2008"],"prefix":"10.4269","volume":"83","author":[{"given":"Matheus P.","family":"Cerroni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean C. S.","family":"Barrado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aglaer A.","family":"Nobrega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alysson B. M.","family":"Lins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iolanda P.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson R.","family":"Mangueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f4mulo H.","family":"da Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra M. 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WHO Technical Report Series No. 724","author":"World Health Organization","year":"1985"},{"key":"R10","series-title":"Fisiologia do Exerc\u00edcio, Energia e Desempenho Humano","author":"Mcardle","year":"2003"},{"key":"R11","series-title":"Am J Clin Nutr","first-page":"347","article-title":"Biochemical evidence of thiamine depletion during the Cuban neuropathy epidemic, 1992\u20131993","volume":"64","author":"Macias-Matos","year":"1996"},{"key":"R12","series-title":"Thiamine Deficiency and Its Prevention and Control in Major Emergences","author":"World Health Organization","year":"1999"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/83\/5\/article-p1093.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/83\/5\/article-p1093.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/83\/5\/article-p1093.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T16:17:19Z","timestamp":1725293839000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/83\/5\/article-p1093.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,5]]},"references-count":12,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.2010.10-0345","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,5]]}}}