{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:14:26Z","timestamp":1784740466075,"version":"3.55.0"},"reference-count":18,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,1]]},"abstract":"<jats:p>We compared clinical features and laboratory findings of 104 patients with hepatitis A and 197 patients with scrub typhus. Nausea, vomiting, abdominal pain, hepatomegaly, and jaundice were common in patient with hepatitis A, and fever and headache were significantly more common in patients with scrub typhus. At presentation, an alanine aminotransferase (ALT) level \u2265 500 U\/L was observed in 1% of scrub typhus patients and in 87.5% of hepatitis A patients (<jats:italic>P &lt;<\/jats:italic> 0.001). A bilirubin level \u2265 1.3 mg\/dL was observed in 16.8% of scrub typhus patients and 90.4% of hepatitis A patients. The ALT:lactate dehydrogenase ratio was \u2264 5 in 97.4% of the patients with scrub typhus and &gt; 5 in 95.2% of those with hepatitis A (<jats:italic>P<\/jats:italic> &lt; 0.001). Fever, headache, rash, and eschar are findings that indicate scrub typhus. An ALT level \u2265 500 U\/L (adjusted odds ratio = 0.011) a bilirubin level \u2265 1.3 (adjusted odds ratio = 0.024), an ALT:lactate dehydrogenase ratio &gt; 5, and hepatomegaly are indications of viral hepatitis A.<\/jats:p>","DOI":"10.4269\/ajtmh.2011.09-0703","type":"journal-article","created":{"date-parts":[[2011,11,2]],"date-time":"2011-11-02T21:52:54Z","timestamp":1320270774000},"page":"873-877","source":"Crossref","is-referenced-by-count":8,"title":["A Comparative Study of Hepatitis Caused by Scrub Typhus and Viral Hepatitis A in South Korea"],"prefix":"10.4269","volume":"85","author":[{"given":"Jun","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na Ra","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Mi","family":"Byeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Dae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Guk","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Ah","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Am J Trop Med Hyg","first-page":"667","article-title":"Short report: abnormal liver function in scrub typhus","volume":"73","author":"Hu","year":"2005"},{"key":"R2","series-title":"Clin Infect Dis","first-page":"1505","article-title":"Clinical features of scrub typhus","volume":"42","author":"Basnyat","year":"2006"},{"key":"R3","series-title":"Clin Microbiol Rev","first-page":"38","article-title":"Hepatitis A: old and new","volume":"14","author":"Cuthbert","year":"2001"},{"key":"R4","series-title":"Vaccine","first-page":"15S","article-title":"Clinical manifestations and diagnosis of hepatitis A virus infection","volume":"10","author":"Koff","year":"1992"},{"key":"R5","series-title":"Korean J Gastroenterol","first-page":"136","article-title":"Clinical features of acute hepatitis A in the western part of Daejeon and Chungnam Province: single center experience [in Korean]","volume":"47","author":"Lee","year":"2006"},{"key":"R6","series-title":"Communicable Diseases Surveillance Yearbook\u2014Viral Hepatitis","first-page":"409","author":"Lee","year":"2007"},{"key":"R7","series-title":"Infect Med","first-page":"236","article-title":"Chigger mites and scrub typhus","volume":"17","author":"Goddard","year":"2000"},{"key":"R8","series-title":"J Clin 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