{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:57:33Z","timestamp":1792267053287,"version":"4.4.0"},"reference-count":16,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,5]]},"abstract":"<jats:p>Some studies showed that children have a lower response to systemic use of pentavalent antimoniate than adults. We aimed to evaluate the response rate to Glucantime therapy in children and compare it with adults. One hundred and twelve patients with acute cutaneous leishmaniais (ACL) were divided into two equal groups of adults (&gt; 15 yrs) and children (\u2264 15 yrs). They received meglumine antimoniate; 20 mg\/kg\/day for 20 days, their improvement rate was evaluated 20 and 45 days after treatment. Perprotocol analysis showed a significantly lower response in the children group 20 and 45 days after initiation of the treatment (<jats:italic>P<\/jats:italic> = 0.0001, 95% confidence interval [CI] = 0.190 [0.079\u20130.456]\/<jats:italic>P<\/jats:italic> = 0.0051, 95% CI = 0.317 [0.140\u20130.717], respectively). Moreover, after intention-to-treat analysis, the same results were seen in the younger group 20 and 45 days after treatment (<jats:italic>P<\/jats:italic> = 0.0003, 95% CI = 0.228 [0.098\u20130.528]\/<jats:italic>P<\/jats:italic> = 0.0132, 95% CI = 0.382 [0.177\u20130.825], respectively). According to our results, systemic Glucantime has lower efficacy in treating ACL in children than adults.<\/jats:p>","DOI":"10.4269\/ajtmh.2011.10-0002","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T13:23:23Z","timestamp":1301664203000},"page":"539-542","source":"Crossref","is-referenced-by-count":22,"title":["Systemic Meglumine Antimoniate in Acute Cutaneous Leishmaniasis: Children versus Adults"],"prefix":"10.4269","volume":"84","author":[{"given":"Pouran","family":"Layegh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Rahsepar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Ali","family":"Rahsepar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"B1","series-title":"Korean J Parasitol","first-page":"355","article-title":"Childhood cutaneous leishmaniasis: report of 117 cases from Iran","volume":"44","author":"Talari","year":"2006"},{"key":"B2","series-title":"Am J Trop Med Hyg","first-page":"187","article-title":"Treatment failure in children in a randomized clinical trial with 10 and 20 days of meglumine antimonate for cutaneous leishmaniasis due to Leishmania viannia species","volume":"64","author":"Palacios","year":"2001"},{"key":"B3","series-title":"J Infect Dis","first-page":"602","article-title":"Pharmacokinetics of antimony in children treated for leishmaniasis with meglumine antimoniate","volume":"195","author":"Cruz","year":"2007"},{"key":"B4","series-title":"Parasitol Res","first-page":"1159","article-title":"Evaluation of PCR assay in diagnosis and identification of cutaneous leishmaniasis: a comparison with the parasitological methods","volume":"103","author":"Shahbazi","year":"2008"},{"key":"B5","series-title":"Bull World Health Organ","first-page":"289","article-title":"Cutaneous leishmaniasis in primary school children in the south-eastern Iranian city of Bam, 1994\u201395","volume":"76","author":"Sharifi","year":"1998"},{"key":"B6","series-title":"J Postgrad Med","first-page":"31","article-title":"An overview of paediatric leishmaniasis","volume":"49","author":"Kafetzis","year":"2003"},{"key":"B7","series-title":"Med Trop","first-page":"487","article-title":"Management of cutaneous leishmaniasis in adults and children","volume":"65","author":"Minodier","year":"2005"},{"key":"B8","series-title":"J Eur Acad Dermatol Venereol","first-page":"765","article-title":"Cryotherapy as an adjunct to systemic antimonials for cutaneous leishmaniasis in children","volume":"20","author":"Stavropoulos","year":"2006"},{"key":"B9","series-title":"Arch Dermatol","first-page":"1575","article-title":"Imiquimod in combination with meglumine antimoniate for cutaneous leishmaniasis: a randomized assessor-blind controlled trial","volume":"142","author":"Firooz","year":"2006"},{"key":"B10","series-title":"Int J Dermatol","first-page":"594","article-title":"Cutaneous leishmaniasis: schedules for intralesional treatment with sodium stibogluconate","volume":"35","author":"Tallab","year":"1996"},{"key":"B11","series-title":"Int J Dermatol","first-page":"521","article-title":"Evaluating the efficacy of allopurinol and meglumine antimoniate (Glucantime) in the treatment of cutaneous leishmaniasis","volume":"41","author":"Esfandiarpour","year":"2002"},{"key":"B12","series-title":"PLoS Med","first-page":"e162","article-title":"Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites","volume":"3","author":"Hadighi","year":"2006"},{"key":"B13","series-title":"Clin Exp Dermatol","first-page":"13","article-title":"Treatment of cutaneous leishmaniasis with either topical paromomycin or intralesional meglumine antimoniate","volume":"28","author":"Faghihi","year":"2003"},{"key":"B14","series-title":"Am J Trop Med Hyg","first-page":"172","article-title":"Efficacy of cryotherapy versus intralesional meglumine antimoniate (Glucantime) for treatment of cutaneous leishmaniasis in children","volume":"80","author":"Layegh","year":"2009"},{"key":"B15","series-title":"Trans R Soc Trop Med Hyg","first-page":"69","article-title":"Pharmacokinetics of antimony during treatment of visceral leishmaniasis with sodium stibogluconate or meglumine antimoniate","volume":"82","author":"Chulay","year":"1988"},{"key":"B16","series-title":"N Engl J Med","first-page":"1157","article-title":"Developmental pharmacology\u2013drug disposition, action, and therapy in infants and children","volume":"349","author":"Kearns","year":"2003"}],"container-title":["The American Society of Tropical Medicine and 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