{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:54:14Z","timestamp":1791197654169,"version":"4.1.0"},"reference-count":31,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,5]]},"abstract":"<jats:p>In malaria-endemic areas, iron deficiency and placental <jats:italic>Plasmodium falciparum<\/jats:italic> infection commonly coexist. In primigravidae and their newborns, hepcidin and other iron parameters were evaluated in groups and classified according to placental <jats:italic>P. falciparum<\/jats:italic> and maternal anemia status. Mothers had relatively high hepcidin levels considering their low iron status. In cord blood, levels of hepcidin, hemoglobin, and other iron parameters were also similar for groups. We conclude that maternal hepcidin is not significantly altered as a function of placental infection and\/or anemia. Importantly, fetal hemoglobin and iron status were also unaffected, regardless of the presence of placental infection or maternal anemia.<\/jats:p>","DOI":"10.4269\/ajtmh.2011.10-0250","type":"journal-article","created":{"date-parts":[[2011,1,6]],"date-time":"2011-01-06T16:27:08Z","timestamp":1294331228000},"page":"148-151","source":"Crossref","is-referenced-by-count":25,"title":["Iron Homeostasis in Mother and Child during Placental Malaria Infection"],"prefix":"10.4269","volume":"84","author":[{"given":"Susanne","family":"Van Santen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quirijn","family":"de Mast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian J. F.","family":"Luty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin T.","family":"Wiegerinck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre J. A. M.","family":"Van der Ven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorine W.","family":"Swinkels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Lancet Infect Dis","first-page":"93","article-title":"Epidemiology and burden of malaria in pregnancy","volume":"7","author":"Desai","year":"2007"},{"key":"R2","series-title":"Clin Microbiol Rev","first-page":"760","article-title":"Impact of malaria during pregnancy on low birth weight in sub-Saharan Africa","volume":"17","author":"Guyatt","year":"2004"},{"key":"R3","series-title":"Lancet Infect Dis","first-page":"105","article-title":"Malaria in pregnancy: pathogenesis and immunity","volume":"7","author":"Rogerson","year":"2007"},{"key":"R4","series-title":"Microbes Infect","first-page":"460","article-title":"The iron trap: iron, malaria and anemia at the mother-child interface","volume":"11","author":"Friedman","year":"2009"},{"key":"R5","series-title":"Worldwide Prevalence of Anemia 1993\u20132005","author":"World Health Organization","year":"2008"},{"key":"R6","series-title":"Lancet","first-page":"133","article-title":"Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial","volume":"14","author":"Sazawal","year":"2006"},{"key":"R7","series-title":"Food Nutr Bull","first-page":"S524","article-title":"Iron metabolism and malaria","volume":"28","author":"Prentice","year":"2007"},{"key":"R8","series-title":"Science","first-page":"2090","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization","volume":"17","author":"Nemeth","year":"2004"},{"key":"R9","series-title":"Acta Haematol","first-page":"78","article-title":"The role of hepcidin in iron metabolism","volume":"122","author":"Nemeth","year":"2009"},{"key":"R10","series-title":"J Infect Dis","first-page":"253","article-title":"Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infection","volume":"199","author":"de Mast","year":"2009"},{"key":"R11","series-title":"Haematologica","first-page":"1068","article-title":"Increased serum hepcidin and alterations in blood iron parameters associated with asymptomatic P. falciparum and P. vivax malaria","volume":"95","author":"de Mast","year":"2010"},{"key":"R12","series-title":"Blood","first-page":"1864","article-title":"Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS, 2005","volume":"106","author":"Kemna","year":"2005"},{"key":"R13","series-title":"Br J Haematol","first-page":"532","article-title":"Localisation of proteins of iron metabolism in the human placenta and liver","volume":"134","author":"Bastin","year":"2006"},{"key":"R14","series-title":"Am J Physiol Regul Integr Comp Physiol","first-page":"R1063","article-title":"Fetal iron status regulates maternal iron metabolism during pregnancy in the rat","volume":"296","author":"Gambling","year":"2009"},{"key":"R15","series-title":"J Neuroendocrinol","first-page":"427","article-title":"Copper and iron transport across the placenta: regulation and interactions","volume":"20","author":"McArdle","year":"2008"},{"key":"R16","series-title":"FEBS Lett","first-page":"187","article-title":"Transferrin receptor 1 mRNA is downregulated in placenta of hepcidin transgenic embryos","volume":"574","author":"Martin","year":"2004"},{"key":"R17","series-title":"J Infect Dis","first-page":"146","article-title":"Reduced cord blood immune effector-cell responsiveness mediated by CD4+ cells induced in utero as a consequence of placental Plasmodium falciparum infection","volume":"193","author":"Brustoski","year":"2006"},{"key":"R18","series-title":"Iron Deficiency Anemia: Assessment, Prevention and Control. 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