{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:34:25Z","timestamp":1761597265548},"reference-count":19,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,5]]},"abstract":"<jats:p>Helminth infections influence the clinical response to certain diseases and are associated with delayed healing time of patients with cutaneous leishmaniasis (CL) caused by <jats:italic>Leishmania braziliensis<\/jats:italic>. We conducted a randomized, double-blind, placebo-controlled clinical trial to examine the role of early versus deferred treatment of intestinal helminth infection on the clinical course of patients with CL treated with pentavalent antimony. (Clinicaltrials.gov number NCT00469495). A total of 90 patients were enrolled, 51.1% (<jats:italic>N<\/jats:italic> = 23) of control patients had persistent lesions at Day 90, compared with 62.2% (<jats:italic>N<\/jats:italic> = 28) in the treatment group (difference 11.1%, 95% confidence interval = \u22129.1\u201330.0%). There was no statistically significant difference in overall time to cure between groups, although there was a tendency for shorter cure times in the control group. This study shows that early introduction of antihelminthic therapy does not improve clinical outcome in patients co-infected with helminths and <jats:italic>L. braziliensis<\/jats:italic>.<\/jats:p>","DOI":"10.4269\/ajtmh.2011.10-0423","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T13:23:23Z","timestamp":1301664203000},"page":"551-555","source":"Crossref","is-referenced-by-count":28,"title":["Antihelminthic Therapy and Antimony in Cutaneous Leishmaniasis: A Randomized, Double-Blind, Placebo-Controlled Trial in Patients Co-Infected with Helminths and Leishmania braziliensis"],"prefix":"10.4269","volume":"84","author":[{"given":"Tracey","family":"Newlove","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz H.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leda","family":"Alc\u00e2ntara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall J.","family":"Glesby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar M.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo R.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"J Infect Dis","first-page":"73","article-title":"Epidemiology of American cutaneous leishmaniasis due to Leishmania braziliensis","volume":"156","author":"Jones","year":"1987"},{"key":"R2","series-title":"Revista da Sociedade Brasiliera de Medicina Tropical","first-page":"447","article-title":"Comparative study of meglumine antimonate, pentamidine isethionate and aminosidine sulfate in the treatment of primary skin lesions caused by Leishmania (Vianna) braziliensis","volume":"29","author":"Correia","year":"1996"},{"key":"R3","series-title":"Am J Trop Med Hyg","first-page":"456","article-title":"Comparison of cutaneous leishmaniasis due to Leishmania (Viannia) braziliensis and L. (V.) guyanensis in Brazil: therapeutic response to meglumine antimoniate","volume":"65","author":"Romero","year":"2001"},{"key":"R4","series-title":"Infect Immun","first-page":"6734","article-title":"Up-regulation of Th1-type responses in mucosal leishmaniasis patients","volume":"70","author":"Bacellar","year":"2002"},{"key":"R5","series-title":"Braz J Med Biol Res","first-page":"143","article-title":"Cytokine profile and pathology in human leishmaniasis","volume":"31","author":"Ribeiro-de-Jesus","year":"1998"},{"key":"R6","series-title":"Mem Inst Oswaldo Cruz","first-page":"51","article-title":"Evaluation of the histopathological classifications of American cutaneous and mucocutaneous leishmaniasis","volume":"86","author":"Bittencourt","year":"1991"},{"key":"R7","series-title":"Clin Infect Dis","first-page":"e69","article-title":"Failure of early treatment of cutaneous leishmaniasis in preventing the development of an ulcer","volume":"34","author":"Machado","year":"2002"},{"key":"R8","series-title":"Mem Inst Oswaldo Cruz","first-page":"225","article-title":"Tumor necrosis factor-alpha in human American tegumentary leishmaniasis","volume":"91","author":"DaCruz","year":"1996"},{"key":"R9","series-title":"J Infect Dis","first-page":"1735","article-title":"Randomized, double-blind study of stibogluconate plus human granulocyte macrophage colony-stimulating factor versus stibogluconate alone in the treatment of cutaneous leishmaniasis","volume":"180","author":"Almeida","year":"1999"},{"key":"R10","series-title":"Am J Trop Med Hyg","first-page":"87","article-title":"Successful treatment of refractory mucosal leishmaniasis with pentoxifylline plus antimony","volume":"65","author":"Lessa","year":"2001"},{"key":"R11","series-title":"J Allergy Clin Immunol","first-page":"947","article-title":"Schistosoma mansoni infection is associated with a reduced course of asthma","volume":"111","author":"Medeiros","year":"2003"},{"key":"R12","series-title":"Am J Gastroenterol","first-page":"2034","article-title":"Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease","volume":"98","author":"Summers","year":"2003"},{"key":"R13","series-title":"Curr Opin Immunol","first-page":"656","article-title":"Infections and allergy\u2013helminths, hygiene and host immune regulation","volume":"17","author":"Maizels","year":"2005"},{"key":"R14","series-title":"J Infect Dis","first-page":"1797","article-title":"Impaired T helper 2 response to aeroallergen in helminth-infected patients with asthma","volume":"190","author":"Araujo","year":"2004"},{"key":"R15","series-title":"J Infect Dis","first-page":"142","article-title":"Influence of helminth infections on the clinical course of and immune response to Leishmania braziliensis cutaneous leishmaniasis","volume":"195","author":"O'Neal","year":"2007"},{"key":"R16","series-title":"Infect Immun","first-page":"508","article-title":"Multiclonal Leishmania braziliensis population structure and its clinical implication in a region of endemicity for American tegumentary leishmaniasis","volume":"72","author":"Schriefer","year":"2004"},{"key":"R17","series-title":"Am J Trop Med Hyg","first-page":"79","article-title":"Selection of a skin test antigen for American visceral leishmaniasis","volume":"35","author":"Reed","year":"1986"},{"year":"2007","series-title":"Guidance, Compliance & Regulatory Information (Biologics)","author":"NIAID Division of AIDS Toxicity Grading Scale","key":"R18"},{"key":"R19","series-title":"Arch Intern Med","first-page":"254","article-title":"Prolonged Salmonella bacteremia in patients with Schistosoma mansoni infection","volume":"128","author":"Rocha","year":"1971"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/84\/4\/article-p551.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/84\/4\/article-p551.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/84\/4\/article-p551.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:56:14Z","timestamp":1723060574000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/84\/4\/article-p551.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,5]]},"references-count":19,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.2011.10-0423","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2011,4,5]]}}}