{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:24:43Z","timestamp":1761488683806},"reference-count":46,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5,5]]},"abstract":"<jats:p>Loiasis, which is caused by the filarial nematode <jats:italic>Loa loa,<\/jats:italic> affects millions of persons living in the rainforest areas and savannah regions of central Africa. Typical manifestations are calabar swellings and the eyeworm. We report a case of loiasis with unusual clinical complications: a peripheral neuropathy and focal hypo-echogenic lesions of the spleen, which disappeared after treatment with albendazole and ivermectin. The literature reports that <jats:italic>L<\/jats:italic>. <jats:italic>loa<\/jats:italic> infection can be associated with various manifestations, some of them being serious. More information is needed to better characterize the protean manifestations of the disease in loiasis-endemic areas to evaluate the true incidence of loiasis.<\/jats:p>","DOI":"10.4269\/ajtmh.2011.10-0458","type":"journal-article","created":{"date-parts":[[2011,5,3]],"date-time":"2011-05-03T18:53:58Z","timestamp":1304448838000},"page":"733-737","source":"Crossref","is-referenced-by-count":16,"title":["Loiasis with Peripheral Nerve Involvement and Spleen Lesions"],"prefix":"10.4269","volume":"84","author":[{"given":"Federico","family":"Gobbi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Boussinesq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Mascarello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Angheben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Gobbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Rossanese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Corach\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeno","family":"Bisoffi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Ann Trop Med Parasitol","first-page":"573","article-title":"Prevalences of Loa loa microfilaraemia throughout the area endemic for the infection","volume":"91","author":"Boussinesq","year":"1997"},{"key":"R2","series-title":"Am J Trop Med","first-page":"345","article-title":"The production of a typical clabar swelling in a Loa patient by injection of a Dirofilaria immitis antigen, and some comments on the nature of Calabar swellings","volume":"10","author":"Chandler","year":"1930"},{"key":"R3","series-title":"Am J Trop Med Hyg","first-page":"684","article-title":"Five cases of encephalitis during treatment of loiasis with diethylcarbamazine","volume":"44","author":"Carme","year":"1991"},{"issue":"(Suppl)","key":"R4","series-title":"Filaria J","first-page":"S4","article-title":"Clinical picture, epidemiology and outcome of Loa-associated serious adverse events related to mass ivermectin treatment of onchocerciasis in Cameroon","volume":"2","author":"Boussinesq","year":"2003"},{"key":"R5","series-title":"Gaz Hebdom Sci Med (Bordeaux)","first-page":"351","article-title":"La filaire de l'oeil (filaria loa) peut-elle d\u00e9terminer des complications c\u00e9r\u00e9brales?","volume":"30","author":"Bertrand-Fontaine","year":"1913"},{"key":"R6","series-title":"Bull Mem Soc Med Hop Paris","first-page":"1092","article-title":"Un cas de filariose c\u00e9r\u00e9brale (double h\u00e9mipl\u00e9gie au cours d'une filariose \u00e0 F. Loa)","volume":"64","author":"Bertrand-Fontaine","year":"1948"},{"key":"R7","series-title":"J Trop Med Hyg","first-page":"229","article-title":"Nematodosis of the central nervous system","volume":"57","author":"Browne","year":"1954"},{"key":"R8","series-title":"Med Trop","first-page":"663","article-title":"Les manifestations neuro-psychiques des filarioses","volume":"14","author":"Gallais","year":"1954"},{"key":"R9","series-title":"Arch Gewerbepathol Gewerbehyg","first-page":"429","article-title":"Loa loa filariosis mit cerebralen komplikationen als berufskrankheit","volume":"15","author":"Bauer","year":"1957"},{"key":"R10","series-title":"Rev Neurol (Paris)","first-page":"656","article-title":"Enc\u00e9phalite puis endocardite fibroblastique d'origine filarienne","volume":"101","author":"Alajouanine","year":"1959"},{"key":"R11","series-title":"Rev Neurol (Paris)","first-page":"381","article-title":"Filariose loa, thrombose de l'art\u00e8re centrale de la r\u00e9tine et syndrome c\u00e9r\u00e9belleux","volume":"107","author":"Langlois","year":"1962"},{"key":"R12","series-title":"Med Trop","first-page":"273","article-title":"R\u00e9flexions sur un cas de m\u00e9ningite aigu\u00eb \u00e0 Microfilaria loa","volume":"3","author":"Bonnet","year":"1943"},{"key":"R13","series-title":"Ann Soc Belg Med Trop","first-page":"235","article-title":"Quatre cas d'enc\u00e9phalite mortelle avec invasion du liquide c\u00e9phalo-rachidien par Microfilaria loa","volume":"32","author":"Kivits","year":"1952"},{"key":"R14","series-title":"Rev Belg Pathol Med Exp","first-page":"232","article-title":"Enc\u00e9phalite \u00e0 Loa-loa trait\u00e9e par l'association de cortisone et de carbamazine","volume":"31","author":"Cauchie","year":"1965"},{"key":"R15","series-title":"Afr Med","first-page":"359","article-title":"A propos d'un cas de m\u00e9ningo-enc\u00e9phalite filarienne \u00e0 Loa loa. 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The pathology of the spleen in drills (Mandrillus leucophaeus) infected with Loa","volume":"54","author":"Duke","year":"1960"},{"key":"R44","series-title":"J Pathol Bacteriol","first-page":"1","article-title":"Fibrotic nodules of the spleen","volume":"78","author":"Raper","year":"1959"},{"key":"R45","series-title":"Bull World Health Organ","first-page":"155","article-title":"Les probl\u00e8mes actuels de la loase","volume":"56","author":"Fain","year":"1978"},{"key":"R46","series-title":"Trop Med Int Health","first-page":"565","article-title":"Genetic epidemiology of host predisposition microfilaraemia in human loiasis","volume":"4","author":"Garcia","year":"1999"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/84\/5\/article-p733.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/84\/5\/article-p733.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/84\/5\/article-p733.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:55:10Z","timestamp":1723060510000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/84\/5\/article-p733.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,5]]},"references-count":46,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.2011.10-0458","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2011,5,5]]}}}