{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:47:22Z","timestamp":1789555642176,"version":"build-2803163510"},"reference-count":33,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,4]]},"abstract":"<jats:p><jats:italic>Angiostrongylus cantonensis<\/jats:italic> meningitis was first reported in Cuba in 1981, and it was recently reported in South America. The aim of this paper is to evaluate the intrathecal immunoglobulin synthesis patterns from Cuba's and Ecuador's patients with angiostrongyliasis; 8 Ecuadorian patients from two different outbreaks and 28 Cuban patients were studied. Simultaneous blood and cerebrospinal fluid simples were taken. Immunoglobulin (Ig) A, IgM, IgG, and albumin were quantified by radial immunodiffusion. Corresponding Reibergrams were applied. A three-Ig pattern was the most frequent in the two groups, but IgM was presented in all Ecuadorian young mature patients; however, in the Cuban children, only 12 of 28 patients had intrathecal IgM, but about 90% had an IgA and IgG synthesis at time of later puncture. This indicates that, with a larger amount of parasites ingested, clinical symptoms are more severe, and a higher frequency of intrathecal IgM synthesis could be observed. This is discussed as a similarity with the intrathecal IgM synthesis in African trypanosomiasis.<\/jats:p>","DOI":"10.4269\/ajtmh.2011.10-0500","type":"journal-article","created":{"date-parts":[[2011,3,3]],"date-time":"2011-03-03T00:40:40Z","timestamp":1299112840000},"page":"406-410","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of Major Immunoglobulins Intrathecal Synthesis Patterns in Ecuadorian and Cuban Patients with Angiostrongyliasis"],"prefix":"10.4269","volume":"84","author":[{"given":"B\u00e1rbara","family":"Padilla-Docal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto J.","family":"Dorta-Contreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiggi","family":"Martini-Robles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Muzzio-Aroca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Alarc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Esther","family":"Magraner-Tarrau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raisa","family":"Bu-Coifiu-Fanego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Rev Neurol","first-page":"632","article-title":"Activaci\u00f3n y bios\u00edntesis intratecal de C3c en ni\u00f1os con meningoencefalitis eosinof\u00edlica por Angiostrongylus cantonensis","volume":"48","author":"Padilla-Docal","year":"2009"},{"key":"R2","series-title":"Lancet Infect Dis","first-page":"621","article-title":"Human angiostrongyliasis","volume":"8","author":"Qiao","year":"2008"},{"key":"R3","series-title":"Rev Neurol","first-page":"999","article-title":"Meningoencefalitis eosinof\u00edlica en Cuba","volume":"32","author":"Dorta-Contreras","year":"2001"},{"key":"R4","series-title":"Trop Med Int Health","first-page":"423","article-title":"Pr\u00e9sence d'Angiostrongylus cantonensis en Ha\u00efti","volume":"8","author":"Raccurt","year":"2003"},{"key":"R5","series-title":"Am J Trop Med Hyg","first-page":"319","article-title":"First report of Angiostrongylus cantonensis in Puerto Rico","volume":"35","author":"Anderson","year":"1986"},{"key":"R6","series-title":"Emerg Infect Dis","first-page":"324","article-title":"Enzootic Angiostrongylus cantonensis in rat and snails after an outbreak of human eosinophilic meningitis, Jamaica","volume":"8","author":"Lindo","year":"2002"},{"key":"R7","series-title":"Trop Med Parasitol","first-page":"253","article-title":"First record of A. cantonensis (Chen, 1935). 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