{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:02:39Z","timestamp":1759341759208},"reference-count":26,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,5]]},"abstract":"<jats:p>Nitroimidazole antibiotics are the mainstay of treatment of invasive amebiasis; however, few comparative studies of applicable antibiotics are available. Evidence of sporadic clinical failure and rare reports of metronidazole resistance have led to the investigation of novel antiamebic therapeutics. The goal of this study was to examine drug efficacy in both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> models of intestinal amebiasis. We studied six current and three novel drugs. Many drugs, including metronidazole, nitazoxanide, and nitazoxanide derivatives, were shown to be potently inhibitory <jats:italic>in vitro<\/jats:italic>. However, metronidazole remained the most effective <jats:italic>in vivo<\/jats:italic>, both in preventative and curative regimens, underscoring the value of animal models in evaluating future therapies.<\/jats:p>","DOI":"10.4269\/ajtmh.2011.10-0580","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T13:23:23Z","timestamp":1301664203000},"page":"581-586","source":"Crossref","is-referenced-by-count":24,"title":["Efficacy of Antiamebic Drugs in a Mouse Model"],"prefix":"10.4269","volume":"84","author":[{"given":"Stephen","family":"Becker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric R.","family":"Houpt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"N Engl J Med","first-page":"1565","article-title":"Amebiasis","volume":"348","author":"Haque","year":"2003"},{"key":"R2","series-title":"N Engl J Med","first-page":"119","article-title":"Spectrum of disease and relation to place of exposure among ill returned travelers","volume":"354","author":"Freedman","year":"2006"},{"key":"R3","series-title":"Rev Infect Dis","first-page":"228","article-title":"Problems in recognition and diagnosis of amebiasis: estimation of the global magnitude of morbidity and mortality","volume":"8","author":"Walsh","year":"1986"},{"key":"R4","series-title":"Gastroenterology","first-page":"35","article-title":"Comparison of metronidazole and chloroquine for the treatment of amoebic liver abscess. 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histolytica","volume":"45","author":"Seifert","year":"2001"},{"key":"R16","series-title":"Bioorg Med Chem Lett","first-page":"187","article-title":"Synthesis and antiparasitic activity of 2-(trifluoromethyl)-benzimidazole derivatives","volume":"11","author":"Navarrete-Vazquez","year":"2001"},{"key":"R17","series-title":"Parasitol Res","first-page":"837","article-title":"Possible role of calcium ions, calcium channels and calmodulin in excystation and metacystic development of Entamoeba invadens","volume":"88","author":"Makioka","year":"2002"},{"key":"R18","series-title":"Med Trop (Mars)","first-page":"31","article-title":"Schistosomiasis and tourism in the Dogon country, Mali","volume":"64","author":"Ranque","year":"2004"},{"key":"R19","series-title":"Eur J Med Chem","first-page":"935","article-title":"1-N-substituted thiocarbamoyl-3-phenyl-2-pyrazolines: synthesis and in vitro antiamoebic activities","volume":"40","author":"Abid","year":"2005"},{"key":"R20","series-title":"Parasitol 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