{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:34:24Z","timestamp":1787315664258,"version":"build-2736575974"},"reference-count":14,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,1]]},"abstract":"<jats:p>\n                    Melioidosis, a bacterial infection caused by\n                    <jats:italic>Burkholderia pseudomallei<\/jats:italic>\n                    , is notoriously difficult to cure despite appropriate antimicrobial therapy and has a mortality rate of up to 40%. We demonstrate that a blood culture positive for\n                    <jats:italic>B. pseudomallei<\/jats:italic>\n                    taken at the end of the first and\/or second week after hospitalization for melioidosis is a strong prognostic factor for death (adjusted odds ratio = 4.2, 95% confidence interval = 2.1\u20138.7,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001 and adjusted odds ratio = 2.6, 95% confidence interval = 1.1\u20136.0,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.03, respectively). However, repeat cultures of respiratory secretions, urine, throat swabs, or pus\/surface swabs provide no prognostic information. This finding highlights the need for follow-up blood cultures in patients with melioidosis.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.2011.10-0618","type":"journal-article","created":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T14:44:22Z","timestamp":1306939462000},"page":"858-861","source":"Crossref","is-referenced-by-count":22,"title":["Repeat Blood Culture Positive for B. pseudomallei Indicates an Increased Risk of Death from Melioidosis"],"prefix":"10.4269","volume":"84","author":[{"given":"Direk","family":"Limmathurotsakul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanaporn","family":"Wuthiekanun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gumphol","family":"Wongsuvan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukanya","family":"Pangmee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premjit","family":"Amornchai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prapit","family":"Teparrakkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nittaya","family":"Teerawattanasook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P. J.","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon J.","family":"Peacock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Am J Trop Med Hyg","first-page":"1113","article-title":"Increasing incidence of human melioidosis in northeast Thailand","volume":"82","author":"Limmathurotsakul","year":"2010"},{"key":"R2","series-title":"Acta Trop","first-page":"121","article-title":"The epidemiology of melioidosis in Australia and Papua New Guinea","volume":"74","author":"Currie","year":"2000"},{"key":"R3","series-title":"J Clin Microbiol","first-page":"2274","article-title":"Role and significance of quantitative urine cultures in diagnosis of melioidosis","volume":"43","author":"Limmathurotsakul","year":"2005"},{"key":"R4","series-title":"Clin Infect Dis","first-page":"1498","article-title":"Prognostic significance of quantitative bacteremia in septicemic melioidosis","volume":"21","author":"Walsh","year":"1995"},{"key":"R5","series-title":"Br J Biomed Sci","first-page":"249","article-title":"The laboratory diagnosis of melioidosis","volume":"53","author":"Walsh","year":"1996"},{"key":"R6","series-title":"Antimicrob Agents Chemother","first-page":"4020","article-title":"Open-label randomized trial of oral trimethoprim-sulfamethoxazole, doxycycline, and chloramphenicol compared with trimethoprim-sulfamethoxazole and doxycycline for maintenance therapy of melioidosis","volume":"49","author":"Chaowagul","year":"2005"},{"key":"R7","series-title":"Clin Infect Dis","first-page":"375","article-title":"A comparison of chloramphenicol, trimethoprim-sulfamethoxazole, and doxycycline with doxycycline alone as maintenance therapy for melioidosis","volume":"29","author":"Chaowagul","year":"1999"},{"key":"R8","series-title":"Clin Infect Dis","first-page":"308","article-title":"A randomized controlled trial of granulocyte colony-stimulating factor for the treatment of severe sepsis due to melioidosis in Thailand","volume":"45","author":"Cheng","year":"2007"},{"key":"R9","series-title":"Clin Infect Dis","first-page":"1105","article-title":"Two randomized controlled trials of ceftazidime alone versus ceftazidime in combination with trimethoprim-sulfamethoxazole for the treatment of severe melioidosis","volume":"41","author":"Chierakul","year":"2005"},{"key":"R10","series-title":"Am J Trop Med Hyg","first-page":"812","article-title":"Quantitation of B. pseudomallei in clinical samples","volume":"77","author":"Wuthiekanun","year":"2007"},{"key":"R11","series-title":"Arch Intern Med","first-page":"2066","article-title":"Clinical identifiers of complicated Staphylococcus aureus bacteremia","volume":"163","author":"Fowler","year":"2003"},{"key":"R12","series-title":"J Intensive Care Med","first-page":"269","article-title":"Ventilator-associated pneumonia patients who do not reduce bacteria from the lungs have a worse prognosis","volume":"18","author":"Baughman","year":"2003"},{"key":"R13","series-title":"Clin Infect Dis","first-page":"381","article-title":"Comparison of imipenem and ceftazidime as therapy for severe melioidosis","volume":"29","author":"Simpson","year":"1999"},{"key":"R14","series-title":"Clin Infect Dis","first-page":"846","article-title":"Ceftazidime vs. amoxicillin\/clavulanate in the treatment of severe melioidosis","volume":"19","author":"Suputtamongkol","year":"1994"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/84\/6\/article-p858.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/84\/6\/article-p858.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/84\/6\/article-p858.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T15:49:31Z","timestamp":1723045771000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/84\/6\/article-p858.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,1]]},"references-count":14,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.2011.10-0618","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,1]]}}}