{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:03:52Z","timestamp":1792260232234,"version":"4.4.0"},"reference-count":44,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"abstract":"<jats:p>Micronutrient deficiencies are associated with impaired growth and cognitive function. A school-based fortification program might benefit schoolchildren but a high prevalence of parasite infestation might affect effectiveness. A randomized, double-blind, placebo-controlled 2 \u00d7 2 factorial trial was conducted to assess the efficacy of multi-micronutrient fortified biscuits with or without de-worming on growth, cognitive function, and parasite load in Vietnamese schoolchildren. Schoolchildren (n = 510), 6\u20138 years of age were randomly allocated to receive albendazole or placebo at baseline and four months of multi-micronutrient fortified biscuits (FB) or non-fortified biscuits. Children receiving FB for four months scored higher on two cognitive tests: Raven's Colored Progressive Matrices and the Digit Span Forward test. Children receiving albendazole plus FB had the lowest parasite load after four months. In children receiving FB, mid-upper arm circumference was slightly improved (+0.082 cm) but there were no differences in other indexes of anthropometry. Combining multi-micronutrient fortified biscuits with de-worming is an effective strategy.<\/jats:p>","DOI":"10.4269\/ajtmh.2011.10-0651","type":"journal-article","created":{"date-parts":[[2011,8,4]],"date-time":"2011-08-04T02:17:25Z","timestamp":1312424245000},"page":"333-340","source":"Crossref","is-referenced-by-count":46,"title":["Decreased Parasite Load and Improved Cognitive Outcomes Caused by Deworming and Consumption of Multi-Micronutrient Fortified Biscuits in Rural Vietnamese Schoolchildren"],"prefix":"10.4269","volume":"85","author":[{"given":"Tran T.","family":"Nga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pattanee","family":"Winichagoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjoleine A.","family":"Dijkhuizen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen C.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emorn","family":"Wasantwisut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank T.","family":"Wieringa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Nutr Rev","first-page":"S46","article-title":"Prevalence of micronutrient malnutrition worldwide","volume":"60","author":"Ramakrishnan","year":"2002"},{"key":"R2","series-title":"Am J Clin Nutr","first-page":"786","article-title":"Concurrent micronutrient deficiencies in lactating mothers and their infants in Indonesia","volume":"73","author":"Dijkhuizen","year":"2001"},{"key":"R3","series-title":"J Nutr","first-page":"3879S","article-title":"Providing micronutrients through food-based solutions: a key to human and national development","volume":"133","author":"Demment","year":"2003"},{"key":"R4","series-title":"J Nutr","first-page":"1473S","article-title":"The evidence linking zinc deficiency with children's cognitive and motor functioning","volume":"133","author":"Black","year":"2003"},{"key":"R5","series-title":"Asia Pac J Clin Nutr","first-page":"32","article-title":"The effects of iodine on intelligence in children: a meta-analysis of studies conducted in China","volume":"14","author":"Qian","year":"2005"},{"key":"R6","series-title":"J Nutr","first-page":"649S","article-title":"A review of studies on the effect of iron deficiency on cognitive development in children","volume":"131","author":"Grantham-McGregor","year":"2001"},{"key":"R7","series-title":"Lancet","first-page":"824","article-title":"Early child development in developing countries","volume":"369","author":"Grantham-McGregor","year":"2007"},{"key":"R8","series-title":"J Nutr","first-page":"2617","article-title":"Developmental trajectories of poorly nourished toddlers that received a micronutrient supplement with and without energy","volume":"132","author":"Pollitt","year":"2002"},{"key":"R9","series-title":"Food Nutr Bull","first-page":"S160","article-title":"Vitamin and mineral deficiencies technical situation analysis: a report for the ten year strategy for the reduction of vitamin and mineral deficiencies","volume":"28","author":"Sanghvi","year":"2007"},{"key":"R10","series-title":"Am J Clin Nutr","first-page":"903","article-title":"Iron and zinc supplementation promote motor development and exploratory behavior among Bangladeshi infants","volume":"80","author":"Black","year":"2004"},{"key":"R11","series-title":"Am J Clin Nutr","first-page":"623","article-title":"Serum retinol concentrations in children are affected by food sources of beta-carotene, fat intake, and anthelmintic drug treatment","volume":"68","author":"Jalal","year":"1998"},{"key":"R12","series-title":"Asia Pac J Clin Nutr","first-page":"716","article-title":"Anemia and intestinal parasite infection in school children in rural Vietnam","volume":"16","author":"Le","year":"2007"},{"issue":"(Suppl 1)","key":"R13","series-title":"Matern Child Nutr","first-page":"118","article-title":"A review and meta-analysis of the impact of intestinal worms on child growth and nutrition","volume":"4","author":"Hall","year":"2008"},{"key":"R14","series-title":"Parasite Immunol","first-page":"577","article-title":"Interactions of malnutrition and immune impairment, with specific reference to immunity against parasites","volume":"28","author":"Hughes","year":"2006"},{"key":"R15","series-title":"Preventive Chemotherapy in Human Helminthiasis: Coordinated Use of Anthelminthic Drugs in Control Interventions: A Manual for Health Professionals and Programme Managers","author":"World Health Organization","year":"2006"},{"key":"R16","series-title":"JAMA","first-page":"1937","article-title":"Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis","volume":"299","author":"Keiser","year":"2008"},{"key":"R17","series-title":"J Nutr","first-page":"660S","article-title":"Multiple micronutrient supplementation improves anemia, micronutrient nutrient status, and growth of Vietnamese infants: double-blind, randomized, placebo-controlled trial","volume":"135","author":"Hop le","year":"2005"},{"key":"R18","series-title":"Report on Anemia and Sub-Clinical Vitamin A Deficiency in Some Provinces in Vietnam","author":"National Institute of Nutrition, Ministry of Health","year":"2006"},{"key":"R19","series-title":"J Nutr","first-page":"2596","article-title":"The use of NaFeEDTA-fortified fish sauce is an effective tool for controlling iron deficiency in women of childbearing age in rural Vietnam","volume":"135","author":"Van Thuy","year":"2005"},{"key":"R20","series-title":"National Nutrition Survey 2009","author":"National Institute of Nutrition","year":"2009"},{"key":"R21","series-title":"J Nutr","first-page":"4010S","article-title":"The effect of micronutrient deficiencies on child growth: a review of results from community-based supplementation trials","volume":"133","author":"Rivera","year":"2003"},{"issue":"(Suppl 2)","key":"R22","series-title":"Br J Nutr","first-page":"S131","article-title":"Effect of micronutrient supplementation on linear growth of children","volume":"85","author":"Bhandari","year":"2001"},{"key":"R23","series-title":"Am J Clin Nutr","first-page":"1062","article-title":"Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials","volume":"75","author":"Brown","year":"2002"},{"key":"R24","series-title":"J Nutr","first-page":"2592","article-title":"Multimicronutrient interventions but not vitamin A or iron interventions alone improve child growth: results of 3 meta-analyses","volume":"134","author":"Ramakrishnan","year":"2004"},{"key":"R25","series-title":"Food Nutr Bull","first-page":"S120","article-title":"Efficacy trials of a micronutrient dietary supplement in schoolchildren and pregnant women in Tanzania","volume":"24","author":"Latham","year":"2003"},{"key":"R26","series-title":"J Nutr","first-page":"2147","article-title":"A multiple-micronutrient-fortified beverage affects hemoglobin, iron, and vitamin A status and growth in adolescent girls in rural Bangladesh","volume":"137","author":"Hyder","year":"2007"},{"key":"R27","series-title":"Am J Clin Nutr","first-page":"1715","article-title":"A micronutrient-fortified seasoning powder reduces morbidity and improves short-term cognitive function, but has no effect on anthropometric measures in primary school children in northeast Thailand: a randomized controlled trial","volume":"87","author":"Manger","year":"2008"},{"key":"R28","series-title":"Am J Clin Nutr","first-page":"497","article-title":"Effect of iron-, iodine-, and beta-carotene-fortified biscuits on the micronutrient status of primary school children: a randomized controlled trial","volume":"69","author":"van Stuijvenberg","year":"1999"},{"key":"R29","series-title":"J Nutr","first-page":"1013","article-title":"Multi-micronutrient-fortified biscuits decreased prevalence of anemia and improved micronutrient status and effectiveness of deworming in rural Vietnamese school children","volume":"139","author":"Nga","year":"2009"},{"key":"R30","series-title":"Principles of Nutritional Assessment","author":"Gibson","year":"1990"},{"key":"R31","series-title":"Training Manual on Diagnosis of Intestinal Parasites","author":"World Health Organization","year":"1998"},{"key":"R32","series-title":"Nutr Rev","first-page":"413","article-title":"The assessment of cognitive performance in children: considerations for detecting nutritional influences","volume":"61","author":"Hughes","year":"2003"},{"key":"R33","series-title":"Food Nutr Bull","first-page":"S129","article-title":"Effect of a multiple-micronutrient-fortified fruit powder beverage on the nutrition status, physical fitness, and cognitive performance of schoolchildren in the Philippines","volume":"24","author":"Solon","year":"2003"},{"key":"R34","series-title":"J Nutr","first-page":"2427","article-title":"Combined iron and folic acid supplementation with or without zinc reduces time to walking unassisted among Zanzibari infants 5- to 11-mo old","volume":"136","author":"Olney","year":"2006"},{"key":"R35","series-title":"Am J Clin Nutr","first-page":"1082","article-title":"Effect of a 12-mo micronutrient intervention on learning and memory in well-nourished and marginally nourished school-aged children: 2 parallel, randomized, placebo-controlled studies in Australia and Indonesia","volume":"86","author":"Osendarp","year":"2007"},{"key":"R36","series-title":"Cochrane Database Syst Rev","first-page":"CD000371","article-title":"Deworming drugs for treating soil-transmitted intestinal worms in children: effects on growth and school performance","author":"Taylor-Robinson","year":"2007"},{"key":"R37","series-title":"Lancet Infect Dis","first-page":"297","article-title":"Micronutrient supplements for children after deworming","volume":"7","author":"Hall","year":"2007"},{"key":"R38","series-title":"J Nutr","first-page":"1834","article-title":"A multinutrient-fortified beverage enhances the nutritional status of children in Botswana","volume":"133","author":"Abrams","year":"2003"},{"key":"R39","series-title":"Eur J Clin Nutr","first-page":"697","article-title":"Effect of zinc on lean tissue synthesis during recovery from malnutrition","volume":"46","author":"Golden","year":"1992"},{"key":"R40","series-title":"Trans R Soc Trop Med Hyg","first-page":"229","article-title":"The effect of iron and multi-micronutrient supplementation on Ascaris lumbricoides reinfection among Zambian schoolchildren","volume":"103","author":"Nchito","year":"2009"},{"key":"R41","series-title":"Am J Clin Nutr","first-page":"50","article-title":"Effect of vitamin A and zinc supplementation on the nutrition of children in northeast Thailand","volume":"56","author":"Udomkesmalee","year":"1992"},{"key":"R42","series-title":"Trans R Soc Trop Med Hyg","first-page":"557","article-title":"Marginal vitamin A deficiency in pigs experimentally infected with Trichuris suis: a model for vitamin A inadequacy in children","volume":"95","author":"Pedersen","year":"2001"},{"key":"R43","series-title":"J Immunol","first-page":"4495","article-title":"Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway","volume":"168","author":"Stephensen","year":"2002"},{"key":"R44","series-title":"Trans R Soc Trop Med Hyg","first-page":"109","article-title":"Effects of multimicronutrient supplementation on helminth reinfection: a randomized, controlled trial in Kenyan schoolchildren","volume":"97","author":"Olsen","year":"2003"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/85\/2\/article-p333.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/85\/2\/article-p333.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/85\/2\/article-p333.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:41:55Z","timestamp":1723059715000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/85\/2\/article-p333.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,1]]},"references-count":44,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.2011.10-0651","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,1]]}}}