{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:17:46Z","timestamp":1790932666283,"version":"4.1.0"},"reference-count":42,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"abstract":"<jats:p>Most <jats:italic>Cryptosporidium<\/jats:italic> infections in humans are caused by <jats:italic>C. parvum<\/jats:italic> or <jats:italic>C. hominis<\/jats:italic>. However, genotyping techniques have identified infections caused by unusual <jats:italic>Cryptosporidium<\/jats:italic> species. <jats:italic>Cryptosporidium meleagridis<\/jats:italic> has been identified in \u2264 1% of persons with diarrhea, although prevalence is higher in developing nations. We examined the infectivity of <jats:italic>C. meleagridis<\/jats:italic> in healthy adults. Five volunteers were challenged with 10<jats:sup>5<\/jats:sup> <jats:italic>C. meleagridis<\/jats:italic> oocysts and monitored six weeks for fecal oocysts and clinical manifestations. Four volunteers had diarrhea; three had detectable fecal oocysts; and one infected volunteer remained asymptomatic. Fecal DNA from two volunteers was amplified by using a polymerase chain reaction specific for the <jats:italic>Cryptosporidium<\/jats:italic> small subunit ribosomal RNA gene. Nucleotide sequence of these amplicons was diagnostic for <jats:italic>C. meleagridis<\/jats:italic>. All infections were self-limited; oocysts were cleared within \u2264 12 days of challenge. These studies establish that healthy adults can be infected and become ill from ingestion of <jats:italic>C. meleagridis<\/jats:italic> oocysts.<\/jats:p>","DOI":"10.4269\/ajtmh.2011.10-0664","type":"journal-article","created":{"date-parts":[[2011,8,4]],"date-time":"2011-08-04T02:17:25Z","timestamp":1312424245000},"page":"238-242","source":"Crossref","is-referenced-by-count":49,"title":["Cryptosporidium meleagridis: Infectivity in Healthy Adult Volunteers"],"prefix":"10.4269","volume":"85","author":[{"given":"Cynthia L.","family":"Chappell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo C.","family":"Okhuysen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Langer-Curry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna E.","family":"Akiyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Widmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saul","family":"Tzipori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"J Clin Microbiol","first-page":"3984","article-title":"Molecular epidemiological analysis of Cryptosporidium spp. in the United Kingdom: results of genotyping Cryptosporidium spp. in 1,705 fecal samples from humans and 105 fecal samples from livestock animals","volume":"38","author":"McLauchlin","year":"2000"},{"key":"R2","series-title":"Euro Surveill","first-page":"pii: 19086","article-title":"Long-term Cryptosporidium typing reveals the aetiology and species-specific epidemiology of human cryptosporidiosis in England and Wales, 2000 to 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