{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T09:21:15Z","timestamp":1770283275055,"version":"3.49.0"},"reference-count":22,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,1]]},"abstract":"<jats:p><jats:italic>Dirofilaria repens<\/jats:italic>, which is usually found in canine subcutaneous tissues, is the main causative agent of human dirofilariasis in the Old Word. However, a relationship between animal and human cases of dirofilariasis caused by <jats:italic>D. repens<\/jats:italic> in a given area has never been demonstrated. The uneven distribution of <jats:italic>D. repens<\/jats:italic> in provinces in Sicily, Italy represented the foundation for this study. We report a human case of ocular infection with <jats:italic>D. repens<\/jats:italic> from Trapani Province, where canine dirofilariasis is endemic. The nematode was morphologically and molecularly identified and surgical removal of the parasite was documented. The relationship between the prevalence of <jats:italic>D. repens<\/jats:italic> in dogs and the occurrence of human cases of ocular dirofilariasis is discussed on the basis of a review of the historical literature.<\/jats:p>","DOI":"10.4269\/ajtmh.2011.10-0719","type":"journal-article","created":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T18:44:22Z","timestamp":1306953862000},"page":"1002-1004","source":"Crossref","is-referenced-by-count":44,"title":["Human Ocular Infection with Dirofilaria repens (Railliet and Henry, 1911) in an Area Endemic for Canine Dirofilariasis"],"prefix":"10.4269","volume":"84","author":[{"given":"Domenico","family":"Otranto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Brianti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Gaglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipe","family":"Dantas-Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Azzaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Giannetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Nematode parasites of vertebrates: their development and transmission","first-page":"417","author":"Anderson","year":"2000"},{"key":"R2","series-title":"Clin Microbiol Rev","first-page":"366","article-title":"Zoonotic filariasis","volume":"11","author":"Orihel","year":"1998"},{"key":"R3","series-title":"Adv Parasitol","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0065-308X(08)00204-2","article-title":"Heartworm disease in animals and humans","volume":"66","author":"McCall","year":"2008"},{"key":"R4","series-title":"Parassitologia","first-page":"231","article-title":"Human dirofilariasis due to Dirofilaria (Nochtiella) repens: an update of world literature from 1995 to 2000","volume":"42","author":"Pampiglione","year":"2000"},{"key":"R5","series-title":"Histopathology","first-page":"344","article-title":"Dirofilariasis due to Dirofilaria repens in Italy, an emergent zoonosis: report of 60 new cases","volume":"38","author":"Pampiglione","year":"2001"},{"key":"R6","series-title":"Histopathology","first-page":"192","article-title":"Dirofilarial human cases in the Old World, attributed to Dirofilaria immitis: a critical analysis","volume":"54","author":"Pampiglione","year":"2009"},{"key":"R7","series-title":"Front Zool","first-page":"1","article-title":"Integrated taxonomy: traditional approach and DNA barcoding for the identification of filarioid worms and related parasites (Nematoda)","volume":"6","author":"Ferri","year":"2009"},{"key":"R8","series-title":"Am J Trop Med Hyg","first-page":"55","article-title":"First evidence of human zoonotic infestation by Onchocerca lupi (Spirurida, Onchocercidae)","volume":"84","author":"Otranto","year":"2011"},{"key":"R9","series-title":"Vet Parasitol","first-page":"368","article-title":"A simple molecular method for discriminating common filarial nematodes of dogs (Canis familiaris)","volume":"141","author":"Casiraghi","year":"2006"},{"key":"R10","series-title":"Keys to the Nematode Parasites of Vertebrates","first-page":"59","author":"Anderson","year":"1976"},{"key":"R11","series-title":"Ann Ottalmol Clin Ocul","first-page":"257","article-title":"La dirofilariosi oculare umana in Italia: descrizione di 6 nuovi casi. 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