{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:55:52Z","timestamp":1789815352914,"version":"4.0.1"},"reference-count":28,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"abstract":"<jats:p>A recent study by our group reported the isolation and partial serological and molecular characterization of four <jats:italic>Leptospira borgpetersenii<\/jats:italic> serogroup Ballum strains. Here, we reproduced experimental leptospirosis in golden Syrian hamsters (<jats:italic>Mesocricetus auratus<\/jats:italic>) and carried out standardization of lethal dose 50% (LD50) of one of these strains (4E). Clinical disease features and histopathologic analyses of tissue lesions were also observed. As results, strain 4E induced lethality in the hamster model with inocula lower than 10 leptospires, and histopathological examination of animals showed typical lesions found in severe leptospirosis. Gross pathological findings were peculiar; animals that died early had more chance of presenting severe jaundice and less chance of presenting pulmonary hemorrhages (<jats:italic>P<\/jats:italic> &lt; 0.01). <jats:italic>L. borgpetersenii<\/jats:italic> serogroup Ballum has had a considerable growth in human leptospirosis cases in recent years. This strain has now been thoroughly characterized and can be used in more studies, especially evaluations of vaccine candidates.<\/jats:p>","DOI":"10.4269\/ajtmh.2011.11-0013","type":"journal-article","created":{"date-parts":[[2011,8,4]],"date-time":"2011-08-04T02:17:25Z","timestamp":1312424245000},"page":"271-274","source":"Crossref","is-referenced-by-count":8,"title":["Highly Virulent Leptospira borgpetersenii Strain Characterized in the Hamster Model"],"prefix":"10.4269","volume":"85","author":[{"given":"Juliana Alcoforado","family":"Diniz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Rodrigues","family":"F\u00e9lix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane","family":"Bonel-Raposo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amilton Clair Pinto","family":"Seixas Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Aleixo","family":"Vasconcellos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Alex","family":"Grassmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odir Ant\u00f4nio","family":"Dellagostin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio Guimar\u00e3es","family":"Aleixo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9verton Fagonde","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Curr Infect Dis Rep","first-page":"51","article-title":"Leptospirosis in the tropics and in travelers","volume":"8","author":"Ricaldi","year":"2006"},{"key":"R2","series-title":"Nat Rev Microbiol","first-page":"736","article-title":"Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen","volume":"7","author":"Ko","year":"2009"},{"key":"R3","series-title":"Lancet Infect Dis","first-page":"757","article-title":"Leptospirosis: a zoonotic disease of global importance","volume":"3","author":"Bharti","year":"2003"},{"key":"R4","series-title":"Emerg Infect Dis","first-page":"505","article-title":"Leptospirosis-associated severe pulmonary hemorrhagic syndrome, Salvador, Brazil","volume":"14","author":"Gouveia","year":"2008"},{"key":"R5","series-title":"Lab Invest","first-page":"273","article-title":"Studies on the pathogenesis of leptospirosis. 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